-
Neuroanatomical substrates of depression in dementia with Lewy bodies and Alzheimer’s disease Geroscience (IF 5.6) Pub Date : 2024-05-15 Manon Querry, Anne Botzung, Benjamin Cretin, Catherine Demuynck, Candice Muller, Alix Ravier, Benoît Schorr, Mary Mondino, Léa Sanna, Paulo Loureiro de Sousa, Nathalie Philippi, Frédéric Blanc
-
Clinical biomarker-based biological age predicts deaths in Brazilian adults: the ELSA-Brasil study Geroscience (IF 5.6) Pub Date : 2024-05-16 Amanda Viana Machado, Juliana Freitas de Mello e Silva, Enrico Antônio Colosimo, Belinda L. Needham, Chams Bicalho Maluf, Luana Giatti, Lidyane V. Camelo, Sandhi Maria Barreto
-
Lifespan effects in male UM-HET3 mice treated with sodium thiosulfate, 16-hydroxyestriol, and late-start canagliflozin Geroscience (IF 5.6) Pub Date : 2024-05-16 Richard A. Miller, David E. Harrison, Gino A. Cortopassi, Ishmael Dehghan, Elizabeth Fernandez, Michael Garratt, John G. Geisler, Brett C. Ginsburg, Melissa L. Han, Catherine C. Kaczorowski, Navasuja Kumar, Scott F. Leiser, Marisa Lopez-Cruzan, Ginger Milne, James R. Mitchell, James F. Nelson, Peter C. Reifsnyder, Adam B. Salmon, Ron Korstanje, Nadia Rosenthal, Randy Strong
-
Amyloid β accelerates age-related proteome-wide protein insolubility Geroscience (IF 5.6) Pub Date : 2024-05-16 Edward Anderton, Manish Chamoli, Dipa Bhaumik, Christina D. King, Xueshu Xie, Anna Foulger, Julie K. Andersen, Birgit Schilling, Gordon J. Lithgow
-
Multi-night acoustic stimulation is associated with better sleep, amyloid dynamics, and memory in older adults with cognitive impairment Geroscience (IF 5.6) Pub Date : 2024-05-14 Céline J. Zeller, Marina Wunderlin, Korian Wicki, Charlotte E. Teunissen, Christoph Nissen, Marc A. Züst, Stefan Klöppel
-
Patient-centered development of clinical outcome assessments in early Parkinson disease: key priorities and advances npj Parkinsons Dis. (IF 9.304) Pub Date : 2024-05-14 Tiago A. Mestre, Glenn T. Stebbins, Diane Stephenson, David Dexter, Karen K. Lee, Yuge Xiao, Tien Dam, Catherine M. Kopil, Tanya Simuni
Novel therapies with the ability to delay disease progression are a gap in the care of people living with Parkinson disease (PD) today. Clinical outcomes assessments (COAs) that are sensitive to the earliest clinical changes in PD are deemed essential for a successful therapeutic development. To understand the current landscape of COAs use in clinical trials in PD and define priorities for future research
-
-
Epidemiology and prevalence of dementia and Alzheimer's disease in American Indians: Data from the Strong Heart Study Alzheimers Dement. (IF 14.0) Pub Date : 2024-05-15 Astrid M. Suchy‐Dicey, Kimiko Domoto‐Reilly, Lonnie Nelson, Suman Jayadev, Dedra S. Buchwald, Thomas J. Grabowski, Kristoffer Rhoads
INTRODUCTIONAccurate epidemiologic estimates for dementia are lacking for American Indians, despite substantive social and health disparities.METHODSThe Strong Heart Study, a population‐based cohort of 11 American Indian tribes, conducted detailed cognitive testing and examinations over two visits approximately 7 years apart. An expert panel reviewed case materials for consensus adjudication of cognitive
-
Associations among plasma, MRI, and amyloid PET biomarkers of Alzheimer's disease and related dementias and the impact of health‐related comorbidities in a community‐dwelling cohort Alzheimers Dement. (IF 14.0) Pub Date : 2024-05-15 Marc D. Rudolph, Courtney L. Sutphen, Thomas C. Register, Christopher T. Whitlow, Kiran K. Solingapuram Sai, Timothy M. Hughes, James R. Bateman, Jeffrey L. Dage, Kristen A. Russ, Michelle M. Mielke, Suzanne Craft, Samuel N. Lockhart
INTRODUCTIONWe evaluated associations between plasma and neuroimaging‐derived biomarkers of Alzheimer's disease and related dementias and the impact of health‐related comorbidities.METHODSWe examined plasma biomarkers (neurofilament light chain, glial fibrillary acidic protein, amyloid beta [Aβ] 42/40, phosphorylated tau 181) and neuroimaging measures of amyloid deposition (Aβ‐positron emission tomography
-
Medial temporal lobe gray matter microstructure in preclinical Alzheimer's disease Alzheimers Dement. (IF 14.0) Pub Date : 2024-05-15 Christopher Brown, Sandhitsu Das, Long Xie, Ilya Nasrallah, John Detre, Alice Chen‐Plotkin, Leslie Shaw, Corey McMillan, Paul Yushkevich, David Wolk
INTRODUCTIONTypical MRI measures of neurodegeneration have limited sensitivity in early disease stages. Diffusion MRI (dMRI) microstructural measures may allow for detection in preclinical stages.METHODSParticipants had dMRI and either beta‐amyloid PET or plasma biomarkers of Alzheimer's pathology within 18 months of MRI. Microstructure was measured in portions of the medial temporal lobe (MTL) with
-
Choriocapillaris reduction accurately discriminates against early‐onset Alzheimer's disease Alzheimers Dement. (IF 14.0) Pub Date : 2024-05-15 William Robert Kwapong, Fei Tang, Peng Liu, Ziyi Zhang, Le Cao, Zijuan Feng, Shiyun Yang, Yang Shu, Heng Xu, Ying Lu, Xinjun Zhao, Baochen Chong, Bo Wu, Ming Liu, Peng Lei, Shuting Zhang
INTRODUCTIONThis study addresses the urgent need for non‐invasive early‐onset Alzheimer's disease (EOAD) prediction. Using optical coherence tomography angiography (OCTA), we present a choriocapillaris model sensitive to EOAD, correlating with serum biomarkers.METHODSEighty‐four EOAD patients and 73 controls were assigned to swept‐source OCTA (SS‐OCTA) or the spectral domain OCTA (SD‐OCTA) cohorts
-
The effect of oral probiotics on response to vaccination in older adults: a systematic review of randomised controlled trials Age Ageing (IF 6.7) Pub Date : 2024-05-15 Hediye Arioz Tunc, Caroline E Childs, Jonathan R Swann, Philip C Calder
This systematic review evaluated the impact of oral probiotics on the immune response to vaccination in older people. A literature search was performed in three electronic databases up to January 2023. Randomised controlled trials (RCTs) conducted in older people (age ≥ 60 years) investigating oral probiotics and vaccine response outcomes were included. Characteristics and outcome data of the included
-
Dietary characteristics of community-dwelling older adults with poor appetite: a cross-sectional analysis Age Ageing (IF 6.7) Pub Date : 2024-05-15 Pia Scheufele, Anja Rappl, Marjolein Visser, Eva Kiesswetter, Dorothee Volkert
Rationale Poor appetite is considered a key factor in the development of malnutrition, a link that can be explained by alterations in dietary intake. Given the limited data on dietary characteristics in community-dwelling older adults with poor appetite, the present study aimed to examine whether poor appetite is associated with lower nutrient intake and more unfavourable food choices. Methods In 569
-
Nutrition for dementia prevention: a state of the art update for clinicians Age Ageing (IF 6.7) Pub Date : 2024-05-15 Rebecca Townsend, Andrea Fairley, Sarah Gregory, Craig Ritchie, Emma Stevenson, Oliver M Shannon
Background and objectives Dementia prevalence continues to rise. It is therefore essential to provide feasible and effective recommendations to encourage healthy brain ageing and reduce dementia risk across the population. Appropriate nutrition represents a potential strategy to mitigate dementia risk and could be recommended by clinicians as part of mid-life health checks and other health initiatives
-
The association between adherence to the EAT-Lancet diet and cognitive ageing Age Ageing (IF 6.7) Pub Date : 2024-05-15 Annick P M van Soest, Ondine van de Rest, Renger F Witkamp, Lisette C P G M de Groot
Background The EAT-Lancet commission has proposed a dietary pattern that is both sustainable and healthy. However, the impact of this diet on cognition in older adults remains unexplored. Therefore, we examined the association between adherence to the EAT-Lancet diet and cognitive ageing. Methods We used data from a previous intervention study involving cognitively healthy community-dwelling adults
-
Association of dietary and nutritional factors with cognitive decline, dementia, and depressive symptomatology in older individuals according to a neurogenesis-centred biological susceptibility to brain ageing Age Ageing (IF 6.7) Pub Date : 2024-05-15 Andrea Du Preez, Sophie Lefèvre-Arbogast, Raúl González-Domínguez, Vikki Houghton, Chiara de Lucia, Hyunah Lee, Dorrain Y Low, Catherine Helmer, Catherine Féart, Cécile Delcourt, Cécile Proust-Lima, Mercè Pallàs, Alex Sánchez-Pla, Mireia Urpi-Sardà, Silvie R Ruigrok, Barbara Altendorfer, Ludwig Aigner, Paul J Lucassen, Aniko Korosi, Claudine Manach, Cristina Andres-Lacueva, Cécilia Samieri, Sandrine
Hippocampal neurogenesis (HN) occurs throughout the life course and is important for memory and mood. Declining with age, HN plays a pivotal role in cognitive decline (CD), dementia, and late-life depression, such that altered HN could represent a neurobiological susceptibility to these conditions. Pertinently, dietary patterns (e.g., Mediterranean diet) and/or individual nutrients (e.g., vitamin D
-
The effect of increased fruit and vegetable consumption on blood pressure and lipids: a pooled analysis of six randomised controlled fruit and vegetable intervention trials Age Ageing (IF 6.7) Pub Date : 2024-05-15 Nour A Elsahoryi, Charlotte E Neville, Chris C Patterson, Michelle C McKinley, Francina R Baldrick, Ciara Mulligan, Damian O McCall, Rebecca L Noad, Ciara Rooney, Ian Wallace, Claire T McEvoy, Steven Hunter, David R McCance, David J Edgar, Stuart J Elborn, Pascal P McKeown, Ian S Young, Rachel E Moore, Anne P Nugent, Jayne V Woodside
Background Increasing fruit and vegetable (FV) consumption is associated with reduced cardiovascular disease risk in observational studies but with little evidence from randomised controlled trials (RCTs). The impact of concurrent pharmacological therapy is unknown. Objective To pool data from six RCTs to examine the effect of increasing FV intake on blood pressure (BP) and lipid profile, also exploring
-
Identifying the relation between food groups and biological ageing: a data-driven approach Age Ageing (IF 6.7) Pub Date : 2024-05-15 Ynte Biemans, Daimy Bach, Pariya Behrouzi, Steve Horvath, Charlotte S Kramer, Simin Liu, JoAnn E Manson, Aladdin H Shadyab, James Stewart, Eric A Whitsel, Bo Yang, Lisette de Groot, Pol Grootswagers
Background Heterogeneity in ageing rates drives the need for research into lifestyle secrets of successful agers. Biological age, predicted by epigenetic clocks, has been shown to be a more reliable measure of ageing than chronological age. Dietary habits are known to affect the ageing process. However, much remains to be learnt about specific dietary habits that may directly affect the biological
-
Biomarker signatures associated with ageing free of major chronic diseases: results from a population-based sample of the EPIC-Potsdam cohort Age Ageing (IF 6.7) Pub Date : 2024-05-15 Robin Reichmann, Matthias B Schulze, Tobias Pischon, Cornelia Weikert, Krasimira Aleksandrova
Background A number of biomarkers denoting various pathophysiological pathways have been implicated in the aetiology and risk of age-related diseases. Hence, the combined impact of multiple biomarkers in relation to ageing free of major chronic diseases, such as cancer, cardiovascular disease and type 2 diabetes, has not been sufficiently explored. Methods We measured concentrations of 13 biomarkers
-
Historic Cognitive Function Trajectories as Predictors of Sedentary Behavior and Physical Activity in Older Adults J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-05-15 Dori E Rosenberg, Yinxiang Wu, Abisola Idu, Mikael Anne Greenwood-Hickman, Susan M McCurry, Andrea Z LaCroix, Pamela A Shaw
Background We examined whether trajectories of cognitive function over 10 years predict later life physical activity (PA), sedentary time (ST), and sleep. Methods Participants were from the Adult Changes in Thought (ACT) cohort study. We included 611 ACT participants who wore accelerometers and had 3+ measures of cognition in the 10 years prior to accelerometer wear. The Cognitive Assessment Screening
-
Differences in daily physical activity by Alzheimer’s risk markers among older adults J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-05-14 Francesca R Marino, Jennifer A Deal, Ryan J Dougherty, Murat Bilgel, Qu Tian, Yang An, Eleanor M Simonsick, Susan M Resnick, Luigi Ferrucci, Adam P Spira, Amal A Wanigatunga, Jennifer A Schrack
BACKGROUND Daily physical activity patterns differ by Alzheimer’s disease (AD) status and might signal cognitive risk. It is critical to understand whether patterns are disrupted early in the AD pathological process. Yet, whether established AD risk markers (β-amyloid (Aβ) or APOE-ε4) are associated with differences in objectively measured activity patterns among cognitively unimpaired older adults
-
Revised Recommendations on Methods for Assessing Multimorbidity Changes over Time: Aligning the Method to the Purpose J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-05-14 Corey L Nagel, Nicholas J Bishop, Anda Botoseneanu, Heather, G Allore, Jason T Newsom, David A Dorr, Ana R Quiñones
Background The rapidly growing field of multimorbidity research demonstrates that changes in multimorbidity in mid- and late-life have far reaching effects on important person-centered outcomes, such as health-related quality of life. However, there are few organizing frameworks and comparatively little work weighing the merits and limitations of various quantitative methods applied to the longitudinal
-
Reliable detection of stochastic epigenetic mutations and associations with cardiovascular aging Geroscience (IF 5.6) Pub Date : 2024-05-13 Yaroslav Markov, Morgan Levine, Albert T. Higgins-Chen
-
Characterizing molecular and synaptic signatures in mouse models of late‐onset Alzheimer's disease independent of amyloid and tau pathology Alzheimers Dement. (IF 14.0) Pub Date : 2024-05-12 Kevin P. Kotredes, Ravi S. Pandey, Scott Persohn, Kierra Elderidge, Charles P Burton, Ethan W. Miner, Kathryn A. Haynes, Diogo Francisco S. Santos, Sean‐Paul Williams, Nicholas Heaton, Cynthia M. Ingraham, Christopher Lloyd, Dylan Garceau, Rita O'Rourke, Sarah Herrick, Claudia Rangel‐Barajas, Surendra Maharjan, Nian Wang, Michael Sasner, Bruce T. Lamb, Paul R. Territo, Stacey J. Sukoff Rizzo, Gregory
INTRODUCTIONMODEL‐AD (Model Organism Development and Evaluation for Late‐Onset Alzheimer's Disease) is creating and distributing novel mouse models with humanized, clinically relevant genetic risk factors to capture the trajectory and progression of late‐onset Alzheimer's disease (LOAD) more accurately.METHODSWe created the LOAD2 model by combining apolipoprotein E4 (APOE4), Trem2*R47H, and humanized
-
Single episode of moderate to severe traumatic brain injury leads to chronic neurological deficits and Alzheimer’s-like pathological dementia Geroscience (IF 5.6) Pub Date : 2024-05-11 Kumar Vaibhav, Mayuri Gulhane, Pankaj Ahluwalia, Manish Kumar, Meenakshi Ahluwalia, Ashiq M. Rafiq, Vibha Amble, Manuela G. Zabala, Jacob B. Miller, Liam Goldman, Ashis K. Mondal, Ferenc Deak, Ravindra Kolhe, Ali S. Arbab, Fernando L. Vale
-
Genome integrity as a potential index of longevity in Ashkenazi Centenarian’s families Geroscience (IF 5.6) Pub Date : 2024-05-09 Mariana Andrawus, Gil Ben David, Ivana Terziyska, Lital Sharvit, Aviv Bergman, Nir Barzilai, Srilakshmi M. Raj, Diddahally R. Govindaraju, Gil Atzmon
-
Intensive antihypertensive treatment does not lower cerebral blood flow or cause orthostatic hypotension in frail older adults Geroscience (IF 5.6) Pub Date : 2024-05-09 Ralf W. J. Weijs, Bente M. de Roos, Dick H. J. Thijssen, Jurgen A. H. R. Claassen
-
The influence of immobility on muscle loss in older people with frailty and fragility fractures Geroscience (IF 5.6) Pub Date : 2024-05-10 Eleanor K. Lunt, Adam L. Gordon, Paul L. Greenhaff, John F. R. Gladman
-
Abnormal EEG microstates in Alzheimer’s disease: predictors of β-amyloid deposition degree and disease classification Geroscience (IF 5.6) Pub Date : 2024-05-10 Yibing Yan, Manman Gao, Zhi Geng, Yue Wu, Guixian Xiao, Lu Wang, Xuerui Pang, Chaoyi Yang, Shanshan Zhou, Hongru Li, Panpan Hu, Xingqi Wu, Kai Wang
-
Young blood-mediated cerebromicrovascular rejuvenation through heterochronic parabiosis: enhancing blood-brain barrier integrity and capillarization in the aged mouse brain Geroscience (IF 5.6) Pub Date : 2024-05-10 Rafal Gulej, Ádám Nyúl-Tóth, Boglarka Csik, Roland Patai, Benjamin Petersen, Sharon Negri, Siva Sai Chandragiri, Santny Shanmugarama, Peter Mukli, Andriy Yabluchanskiy, Shannon Conley, Derek Huffman, Stefano Tarantini, Anna Csiszar, Zoltan Ungvari
-
Untargeted serum metabolic profiling of diabetes mellitus among Parkinson’s disease patients npj Parkinsons Dis. (IF 9.304) Pub Date : 2024-05-10 Shiwen Li, Yuyuan Lin, Dean Jones, Douglas I. Walker, Aline Duarte Folle, Irish Del Rosario, Yu Yu, Keren Zhang, Adrienne M. Keener, Jeff Bronstein, Beate Ritz, Kimberly C. Paul
-
Quality of plant-based diets and frailty incidence: a prospective analysis of UK biobank participants Age Ageing (IF 6.7) Pub Date : 2024-05-10 Javier Maroto-Rodriguez, Rosario Ortolá, Esther García-Esquinas, Stefanos N Kales, Fernando Rodríguez-Artalejo, Mercedes Sotos-Prieto
Background Substantial evidence supports the inverse association between adherence to healthy dietary patterns and frailty risk. However, the role of plant-based diets, particularly their quality, is poorly known. Objective To examine the association of two plant-based diets with incidence of physical frailty in middle-aged and older adults. Design Prospective cohort. Setting United Kingdom Subjects
-
Association between physical fitness and executive functions in cognitively healthy female older adults: a cross-sectional study Geroscience (IF 5.6) Pub Date : 2024-05-09 Shirko Ahmadi, Isadora Quirion, Pierre Faivre, Pierre Philippe Wilson Registe, Myles W. O’Brien, Nick W. Bray, Olivier Dupuy, Martin Sénéchal, Mathieu Bélanger, Said Mekari
-
Evaluating osteoporosis and bone quality in the aging spine: modern considerations for surgical management in the geriatric population Geroscience (IF 5.6) Pub Date : 2024-05-04 Miles Hudson, Jenna Meyer, Alexander Evans, Chandan Krishna, Zachary A. Smith, Joshua Bakhsheshian
-
Hemodynamic gain index and risk of chronic kidney disease: A prospective cohort study of middle-aged and older men Geroscience (IF 5.6) Pub Date : 2024-05-06 Setor K. Kunutsor, Jari A. Laukkanen
-
Age-related shifts in mental health determinants from a deprived area in the European Union: informing the national healthy aging program of Hungary Geroscience (IF 5.6) Pub Date : 2024-05-07 Nora Kovacs, Eva Biro, Peter Piko, Zoltan Ungvari, Roza Adany
Mental disorders are among the leading causes of disability worldwide, disproportionately affecting older people. This study aims to assess the mental health of elderly individuals living in a deprived region of Hungary, and to identify and estimate the weight of different determinants of mental health across different age groups. A cross-sectional study was conducted with randomly selected samples
-
Sex-specific relationships of inflammatory biomarkers with blood pressure in older adults Geroscience (IF 5.6) Pub Date : 2024-05-08 Joanna Sulicka-Grodzicka, Barbara Wizner, Tomasz Zdrojewski, Małgorzata Mossakowska, Monika Puzianowska-Kuźnicka, Jerzy Chudek, Andrzej Więcek, Mariusz Korkosz, Elisabetta Caiazzo, Pasquale Maffia, Mateusz Siedlinski, Franz H. Messerli, Tomasz J. Guzik
-
Physical Activity Fragmentation and Falls in Older Adults: Findings from the National Health and Aging Trends Study J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-05-09 Braden K Popelsky, Kelley Pettee Gabriel, Erin E Dooley, Kelly R Ylitalo
Background Physical activity (PA) may be an important fall prevention strategy. Current PA guidelines emphasize total PA dose, but daily patterning of PA is underappreciated. With aging, PA bouts become less frequent and shorter in duration (i.e.: more fragmented). PA fragmentation may be an indicator of fall risk, but the relationship is not well understood. This study examined daily PA accumulation
-
Social environment, lifestyle, and genetic predisposition with dementia risk: A long-term longitudinal study among older adults J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-05-09 Shu Chen, Shanquan Chen, Katja Hanewald, Yafei Si, Hazel Bateman, Bingqin Lin, Xiaolin Xu, Suraj Samtani, Chenkai Wu, Henry Brodaty
Background The role of social environment, i.e., the aggregate effect of social determinants of health (SDOHs), in determining dementia is unclear. Methods We developed a novel polysocial risk score for dementia based on 19 SDOH among 5,199 participants in the Health and Retirement Study, US, to measure the social environmental risk. We used a survival analysis approach to assess the association between
-
Drug Burden Index is a Modifiable Predictor of 30-Day-Hospitalization in Community-Dwelling Older Adults with Complex Care Needs: Machine Learning Analysis of InterRAI Data J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-05-09 Robert T Olender, Sandipan Roy, Hamish A Jamieson, Sarah N Hilmer, Prasad S Nishtala
Background Older adults (≥ 65 years) account for a disproportionately high proportion of hospitalization and in-hospital mortality, some of which may be avoidable. Although machine learning (ML) models have already been built and validated for predicting hospitalization and mortality, there remains a significant need to optimise ML models further. Accurately predicting hospitalization may tremendously
-
Associations and Mediating Pathways between Childhood Adversity and Risk of Dementia: A Cohort Study in the UK Biobank J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-05-09 Wei Hu, Weibo Zhang, Baopeng Liu, Cunxian Jia
Background While childhood adversity (CA) is known to be associated with multiple adverse outcomes, its link with dementia is an area with limited exploration and inconsistent agreement. The study aimed to examine the longitudinal associations of CA with incident all-cause dementia and to quantify the potential mediating pathways. Methods Data from the UK Biobank. CA, encompassing neglect and abuse
-
The untapped potential of comparative biology in aging research; insights from the extraordinary-long-lived naked mole-rat J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-05-09 Rochelle Buffenstein, Vince G Amoroso
The search for solutions to the vagaries of aging have, historically, been akin to searching at night in the bright light under street lamps by utilizing the few preexisting and well-established animal model systems. Throughout my career as a comparative biologist, I have ventured into the darkness across four continents and studied over 150 different animal species, many of which have evolved remarkable
-
Transcriptomic imputation of genetic risk variants uncovers novel whole-blood biomarkers of Parkinson’s disease npj Parkinsons Dis. (IF 9.304) Pub Date : 2024-05-08 Gabriel Chew, Aaron Shengting Mai, John F. Ouyang, Yueyue Qi, Yinxia Chao, Qing Wang, Enrico Petretto, Eng-King Tan
-
Genetic variation and pesticide exposure influence blood DNA methylation signatures in females with early-stage Parkinson’s disease npj Parkinsons Dis. (IF 9.304) Pub Date : 2024-05-07 S. L. Schaffner, W. Casazza, F. Artaud, C. Konwar, S. M. Merrill, C. Domenighetti, J. M. Schulze-Hentrich, S. Lesage, A. Brice, J. C. Corvol, S. Mostafavi, J. K. Dennis, A. Elbaz, M. S. Kobor
-
Antidepressant exposure and long‐term dementia risk in a nationwide retrospective study on US veterans with midlife major depressive disorder Alzheimers Dement. (IF 14.0) Pub Date : 2024-05-08 Jaime Ramos‐Cejudo, June K. Corrigan, Chunlei Zheng, Kaitlin N. Swinnerton, Sean R. Jacobson, Jennifer La, Rebecca A. Betensky, Ricardo S. Osorio, Sharon Madanes, Nunzio Pomara, Dan Iosifescu, Mary Brophy, Nhan V. Do, Nathanael R. Fillmore
INTRODUCTIONThe use of antidepressants in major depressive disorder (MDD) has been reported to influence long‐term risk of Alzheimer's disease (AD) and AD‐related dementias (AD/ADRD), but studies are conflicting.METHODSWe used inverse probability weighted (IPW) Cox models with time‐varying covariates in a retrospective cohort study among midlife veterans with MDD within the US Veterans Affairs healthcare
-
Blood biomarkers of Alzheimer's disease in the community: Variation by chronic diseases and inflammatory status Alzheimers Dement. (IF 14.0) Pub Date : 2024-05-08 Martina Valletta, Davide Liborio Vetrano, Debora Rizzuto, Bengt Winblad, Marco Canevelli, Sarah Andersson, Matilda Dale, Claudia Fredolini, Laura Fratiglioni, Giulia Grande
INTRODUCTIONWe explored the variations of blood biomarkers of Alzheimer's disease (AD) by chronic diseases and systemic inflammation.METHODSWe explored the association of AD blood biomarkers with chronic diseases and systemic inflammation (interleukin‐6 [IL‐6]), in 2366 dementia‐free participants of the Swedish National Study on Aging and Care‐in Kungsholmen, using quantile regression models.RESULTSA
-
Altered fornix integrity is associated with sleep apnea‐related hypoxemia in mild cognitive impairment Alzheimers Dement. (IF 14.0) Pub Date : 2024-05-08 Nicola Andrea Marchi, Véronique Daneault, Claire André, Marie‐Ève Martineau‐Dussault, Andrée‐Ann Baril, Cynthia Thompson, Jacques Yves Montplaisir, Danielle Gilbert, Dominique Lorrain, Arnaud Boré, Maxime Descoteaux, Julie Carrier, Nadia Gosselin
INTRODUCTIONThe limbic system is critical for memory function and degenerates early in the Alzheimer's disease continuum. Whether obstructive sleep apnea (OSA) is associated with alterations in the limbic white matter tracts remains understudied.METHODSPolysomnography, neurocognitive assessment, and brain magnetic resonance imaging (MRI) were performed in 126 individuals aged 55–86 years, including
-
Long‐term exposure to air pollution and road traffic noise and incidence of dementia in the Danish Nurse Cohort Alzheimers Dement. (IF 14.0) Pub Date : 2024-05-08 Stéphane Tuffier, Jiawei Zhang, Marie Bergmann, Rina So, George Maria Napolitano, Thomas Cole‐Hunter, Matija Maric, Sonja Antic, Jørgen Brandt, Matthias Ketzel, Steffen Loft, Youn‐Hee Lim, Zorana Jovanovic Andersen
INTRODUCTIONWe examined the association of long‐term exposure to air pollution and road traffic noise with dementia incidence in the Danish Nurse Cohort.METHODSFemale nurses were followed for dementia incidence (hospital contact or medication prescription) from 1993/1999 to 2020. Air pollution and road traffic noise levels were estimated at nurses’ residences, and their associations with dementia were
-
Proteomic changes in the human cerebrovasculature in Alzheimer's disease and related tauopathies linked to peripheral biomarkers in plasma and cerebrospinal fluid Alzheimers Dement. (IF 14.0) Pub Date : 2024-05-07 Aleksandra M. Wojtas, Eric B. Dammer, Qi Guo, Lingyan Ping, Ananth Shantaraman, Duc M. Duong, Luming Yin, Edward J. Fox, Fatemeh Seifar, Edward B. Lee, Erik C. B. Johnson, James J. Lah, Allan I. Levey, Yona Levites, Srikant Rangaraju, Todd E. Golde, Nicholas T. Seyfried
INTRODUCTIONCerebrovascular dysfunction is a pathological hallmark of Alzheimer's disease (AD). Nevertheless, detecting cerebrovascular changes within bulk tissues has limited our ability to characterize proteomic alterations from less abundant cell types.METHODSWe conducted quantitative proteomics on bulk brain tissues and isolated cerebrovasculature from the same individuals, encompassing control
-
The impact of maternal smoking during pregnancy and the age of smoking initiation on incident dementia: A prospective cohort study Alzheimers Dement. (IF 14.0) Pub Date : 2024-05-07 Jiyong Liu, Yi Xiao, Xiaoting Zheng, Yangfan Cheng, Sirui Zhang, Yuanzheng Ma, Qirui Jiang, Shichan Wang, Chunyu Li, Huifang Shang
INTRODUCTIONThe impact of early‐life tobacco exposure on dementia has remained unknown.METHODSUsing the UK Biobank, the associations of maternal smoking during pregnancy (MSDP) and age of smoking initiation (ASI) with the onset time of all‐cause dementia were estimated with accelerated failure time models. The effects of MSDP and ASI on brain structure and their genetic correlation to Alzheimer's disease
-
Correlation analysis of peripheral platelet markers and disease phenotypes in Alzheimer's disease Alzheimers Dement. (IF 14.0) Pub Date : 2024-05-07 Jiajia Fu, Xiaohui Lai, Chongwei Zhang, Qianqian Wei, Xueping Chen, Huifang Shang
INTRODUCTIONPlatelets serve as the primary peripheral reservoir of amyloid beta (Aβ). However, there is limited research on platelet markers in routine blood examinations, particularly with regard to the large platelet ratio (P‐LCR) in Alzheimer's disease (AD).METHODSThis study included 512 AD patients and 205 healthy controls (HCs). Platelet markers and apolipoprotein E (APOE) 4 status were assessed
-
Assessment of neurovascular uncoupling: APOE status is a key driver of early metabolic and vascular dysfunction Alzheimers Dement. (IF 14.0) Pub Date : 2024-05-07 Kristen D. Onos, Peter B. Lin, Ravi S. Pandey, Scott A. Persohn, Charles P. Burton, Ethan W. Miner, Kierra Eldridge, Jonathan Nyandu Kanyinda, Kate E. Foley, Gregory W. Carter, Gareth R. Howell, Paul R. Territo
BACKGROUNDAlzheimer's disease (AD) is the most common cause of dementia worldwide, with apolipoprotein Eε4 (APOEε4) being the strongest genetic risk factor. Current clinical diagnostic imaging focuses on amyloid and tau; however, new methods are needed for earlier detection.METHODSPET imaging was used to assess metabolism‐perfusion in both sexes of aging C57BL/6J, and hAPOE mice, and were verified
-
A systematic review/meta‐analysis of prevalence and incidence rates illustrates systemic underrepresentation of individuals racialized as Asian and/or Asian‐American in ADRD research Alzheimers Dement. (IF 14.0) Pub Date : 2024-05-06 Yiqi Zhu, Soobin Park, Ramana Kolady, Wenqing Zha, Ying Ma, Amanda Dias, Katherine McGuire, Angela Hardi, Sunny Lin, Zahinoor Ismail, Paris B. Adkins‐Jackson, Jean‐Francois Trani, Ganesh M. Babulal
We investigate Alzheimer's disease and related dementia (ADRD) prevalence, incidence rate, and risk factors in individuals racialized as Asian and/or Asian‐American and assess sample representation. Prevalence, incidence rate, risk factors, and heterogeneity of samples were assessed. Random‐effects meta‐analysis was conducted, generating pooled estimates. Of 920 records across 14 databases, 45 studies
-
Generating real‐world evidence in Alzheimer's disease: Considerations for establishing a core dataset Alzheimers Dement. (IF 14.0) Pub Date : 2024-05-06 James E. Galvin, Jeffrey L. Cummings, Mihaela Levitchi Benea, Carl de Moor, Ricardo F. Allegri, Alireza Atri, Howard Chertkow, Claire Paquet, Verna R. Porter, Craig W. Ritchie, Sietske A. M. Sikkes, Michael R. Smith, Christina Marsica Grassi, Ivana Rubino
Ongoing assessment of patients with Alzheimer's disease (AD) in postapproval studies is important for mapping disease progression and evaluating real‐world treatment effectiveness and safety. However, interpreting outcomes in the real world is challenging owing to variation in data collected across centers and specialties and greater heterogeneity of patients compared with trial participants. Here
-
Sarcopenia prevalence using handgrip strength or chair stand performance in adults living with type 2 diabetes mellitus Age Ageing (IF 6.7) Pub Date : 2024-05-06 Archie E Belfield, Thomas J Wilkinson, Joseph Henson, Jack A Sargeant, Leigh Breen, Andrew P Hall, Melanie J Davies, Thomas Yates
Background The updated European Working Group on Sarcopenia in Older People (EWGSOP2) recommends handgrip strength (HGS) and the chair stand test (CST) to assess muscle strength, with the CST being a convenient proxy for lower limb strength. However, adiposity may differentially influence these strength criteria and produce discrepant sarcopenia prevalence. Objective To determine the prevalence of
-
How do primary care clinicians approach the management of frailty? A qualitative interview study Age Ageing (IF 6.7) Pub Date : 2024-05-06 Anna Seeley, Margaret Glogowska, Gail Hayward
Background Around 15% of adults aged over 65 live with moderate or severe frailty. Contractual requirements for management of frailty are minimal and neither incentivised nor reinforced. Previous research has shown frailty identification in primary care is ad hoc and opportunistic, but there has been little focus on the challenges of frailty management, particularly within the context of recent introduction
-
Sporadic Creutzfeldt-Jakob disease in adults over 80 years: a 10-year review of United Kingdom surveillance Age Ageing (IF 6.7) Pub Date : 2024-05-06 Eugene Ace McDermott, Neil Watson, Johnny Tam, John Centola, Hatice Kurucu King, Jan Mackenzie, David Summers, Alison Green, Marcelo A Barria, Colin Smith, Suvankar Pal
Introduction Sporadic Creutzfeldt-Jakob disease (sCJD) is a rapidly progressive neurodegenerative disease with public health implications. Mean age of onset is 68 years. Age-specific incidence declines after 80 years. This may arise from under-ascertainment or other biological features of the disease. Accurate characterisation of late-onset sCJD is important for early diagnosis, avoiding unnecessary
-
Efficacy of ferric carboxymaltose on haemoglobin response among older patients with gastrointestinal bleeding: a randomised clinical trial Age Ageing (IF 6.7) Pub Date : 2024-05-06 Nicolas Richard, Nadia Arab-Hocine, Margot Vannier, Rachida Leblanc-Boubchir, Agnès Pelaquier, Arnaud Boruchowicz, Marietta Musikas, Morgane Amil, Mathurin Fumery, Stéphane Nahon, Ramuntcho Arotcarena, Eve Gelsi, Arnaud Maurin, Xavier Hébuterne, Guillaume Savoye
Background Acute gastrointestinal bleeding (AGIB) is common in older patients but the use of iron in this context remains understudied. Aims This study aimed to evaluate prospectively the efficacy of ferric carboxymaltose to treat anaemia in older patients after AGIB. Methods This randomised double-blinded placebo-controlled clinical trial was conducted in 10 French centres. Eligible patients were
-
‘I think we could probably do more’: an interview study to explore community pharmacists’ experiences and perspectives of frailty and optimising medicines use in frail older adults Age Ageing (IF 6.7) Pub Date : 2024-05-06 Lucy Faulkner, Carmel M Hughes, Heather E Barry
Background Community pharmacists potentially have an important role to play in identification of frailty and delivery of interventions to optimise medicines use for frail older adults. However, little is known about their knowledge or views about this role. Aim To explore community pharmacists’ knowledge of frailty and assessment, experiences and contact with frail older adults, and perceptions of
-
New horizon in improving ageing with improvisational theatre Age Ageing (IF 6.7) Pub Date : 2024-05-06 Shoshi Keisari, Kristin R Krueger, Boaz M Ben-David, Mathieu Hainselin
Cognitive decline, mental health and mindset factors can all affect the autonomy and well-being of older adults. As the number of older adults across the globe increases, interventions to improve well-being are urgently needed. Improvisational theatre (improv) and improv-based interventions are well-suited to address this need. Studies have shown that participation in improv-based interventions has