Type 2 diabetes mellitus (T2DM) is a common comorbidity among Parkinson’s disease (PD) patients. Yet, little is known about dysregulated pathways that are unique in PD patients with T2DM. We applied high-resolution metabolomic profiling in serum samples of 636 PD and 253 non-PD participants recruited from Central California. We conducted an initial discovery metabolome-wide association and pathway enrichment analysis. After adjusting for multiple testing, in positive (or negative) ion mode, 30 (25) metabolic features were associated with T2DM in both PD and non-PD participants, 162 (108) only in PD participants, and 32 (7) only in non-PD participants. Pathway enrichment analysis identified 17 enriched pathways associated with T2DM in both the PD and non-PD participants, 26 pathways only in PD participants, and 5 pathways only in non-PD participants. Several amino acid, nucleic acids, and fatty acid metabolisms were associated with T2DM only in the PD patient group suggesting a possible link between PD and T2DM.

2 型糖尿病 (T2DM) 是帕金森病 (PD) 患者的常见合并症。然而，对于患有 T2DM 的 PD 患者特有的失调途径知之甚少。我们对从加州中部招募的 636 名帕金森病参与者和 253 名非帕金森病参与者的血清样本进行了高分辨率代谢组学分析。我们进行了初步发现的代谢组范围关联和通路富集分析。调整多重测试后，在正（或负）离子模式下，PD 和非 PD 参与者中有 30 (25) 个代谢特征与 T2DM 相关，仅 PD 参与者有 162 (108) 个代谢特征与 T2DM 相关，仅在 PD 参与者中有 32 (7) 个代谢特征与 T2DM 相关。非 PD 参与者。通路富集分析在 PD 和非 PD 参与者中确定了 17 条与 T2DM 相关的富集通路，仅在 PD 参与者中确定了 26 条通路，仅在非 PD 参与者中确定了 5 条通路。仅在 PD 患者组中，一些氨基酸、核酸和脂肪酸代谢与 T2DM 相关，这表明 PD 和 T2DM 之间可能存在联系。