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Imprinting of serum neutralizing antibodies by Wuhan-1 mRNA vaccines Nature (IF 64.8) Pub Date : 2024-05-15 Chieh-Yu Liang, Saravanan Raju, Zhuoming Liu, Yuhao Li, Guha Asthagiri Arunkumar, James Brett Case, Suzanne M. Scheaffer, Seth J. Zost, Cory M. Acreman, Matthew Gagne, Shayne F. Andrew, Deborah Carolina Carvalho dos Anjos, Kathryn E. Foulds, Jason S. McLellan, James E. Crowe, Daniel C. Douek, Sean P. J. Whelan, Sayda M. Elbashir, Darin K. Edwards, Michael S. Diamond
Immune imprinting is a phenomenon in which prior antigenic experiences influence responses to subsequent infection or vaccination1,2. The effects of immune imprinting on serum antibody responses after boosting with variant-matched SARS-CoV-2 vaccines remain uncertain. Here, we characterized the serum antibody responses after mRNA vaccine boosting of mice and human clinical trial participants. In mice
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Organoids merge to model the blood–brain barrier Nature (IF 64.8) Pub Date : 2024-05-15
Combining a brain organoid with a blood-vessel organoid yields a system similar to a protective mesh in the brain.
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Controlled failure: The building designed to limit catastrophe Nature (IF 64.8) Pub Date : 2024-05-15
New design - inspired by lizard tails - could save lives by isolating collapsing sections of damaged buildings
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Evolution of a novel adrenal cell type that promotes parental care Nature (IF 64.8) Pub Date : 2024-05-15 Natalie Niepoth, Jennifer R. Merritt, Michelle Uminski, Emily Lei, Victoria S. Esquibies, Ina B. Bando, Kimberly Hernandez, Christoph Gebhardt, Sarah A. Wacker, Stefano Lutzu, Asmita Poudel, Kiran K. Soma, Stephanie Rudolph, Andres Bendesky
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Suppressed thermal transport in silicon nanoribbons by inhomogeneous strain Nature (IF 64.8) Pub Date : 2024-05-15 Lin Yang, Shengying Yue, Yi Tao, Shuo Qiao, Hang Li, Zhaohe Dai, Bai Song, Yunfei Chen, Jinlong Du, Deyu Li, Peng Gao
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The rise of baobab trees in Madagascar Nature (IF 64.8) Pub Date : 2024-05-15 Jun-Nan Wan, Sheng-Wei Wang, Andrew R. Leitch, Ilia J. Leitch, Jian-Bo Jian, Zhang-Yan Wu, Hai-Ping Xin, Mijoro Rakotoarinivo, Guy Eric Onjalalaina, Robert Wahiti Gituru, Can Dai, Geoffrey Mwachala, Ming-Zhou Bai, Chen-Xi Zhao, Hong-Qi Wang, Sheng-Lan Du, Neng Wei, Guang-Wan Hu, Si-Chong Chen, Xiao-Ya Chen, Tao Wan, Qing-Feng Wang
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Arresting failure propagation in buildings through collapse isolation Nature (IF 64.8) Pub Date : 2024-05-15 Nirvan Makoond, Andri Setiawan, Manuel Buitrago, Jose M. Adam
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Dispersion-assisted high-dimensional photodetector Nature (IF 64.8) Pub Date : 2024-05-15 Yandong Fan, Weian Huang, Fei Zhu, Xingsi Liu, Chunqi Jin, Chenzi Guo, Yang An, Yuri Kivshar, Cheng-Wei Qiu, Wei Li
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GLP-1-directed NMDA receptor antagonism for obesity treatment Nature (IF 64.8) Pub Date : 2024-05-15 Jonas Petersen, Mette Q. Ludwig, Vaida Juozaityte, Pablo Ranea-Robles, Charlotte Svendsen, Eunsang Hwang, Amalie W. Kristensen, Nicole Fadahunsi, Jens Lund, Alberte W. Breum, Cecilie V. Mathiesen, Luisa Sachs, Roger Moreno-Justicia, Rebecca Rohlfs, James C. Ford, Jonathan D. Douros, Brian Finan, Bryan Portillo, Kyle Grose, Jacob E. Petersen, Mette Trauelsen, Annette Feuchtinger, Richard D. DiMarchi
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Photocatalytic doping of organic semiconductors Nature (IF 64.8) Pub Date : 2024-05-15 Wenlong Jin, Chi-Yuan Yang, Riccardo Pau, Qingqing Wang, Eelco K. Tekelenburg, Han-Yan Wu, Ziang Wu, Sang Young Jeong, Federico Pitzalis, Tiefeng Liu, Qiao He, Qifan Li, Jun-Da Huang, Renee Kroon, Martin Heeney, Han Young Woo, Andrea Mura, Alessandro Motta, Antonio Facchetti, Mats Fahlman, Maria Antonietta Loi, Simone Fabiano
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The temperature sensor TWA1 is required for thermotolerance in Arabidopsis Nature (IF 64.8) Pub Date : 2024-05-15 Lisa Bohn, Jin Huang, Susan Weidig, Zhenyu Yang, Christoph Heidersberger, Bernard Genty, Pascal Falter-Braun, Alexander Christmann, Erwin Grill
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Temporal multiplexing of perception and memory codes in IT cortex Nature (IF 64.8) Pub Date : 2024-05-15 Liang She, Marcus K. Benna, Yuelin Shi, Stefano Fusi, Doris Y. Tsao
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Superconducting diode effect and interference patterns in kagome CsV3Sb5 Nature (IF 64.8) Pub Date : 2024-05-15 Tian Le, Zhiming Pan, Zhuokai Xu, Jinjin Liu, Jialu Wang, Zhefeng Lou, Xiaohui Yang, Zhiwei Wang, Yugui Yao, Congjun Wu, Xiao Lin
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Physiological temperature drives TRPM4 ligand recognition and gating Nature (IF 64.8) Pub Date : 2024-05-15 Jinhong Hu, Sung Jin Park, Tyler Walter, Ian J. Orozco, Garrett O‘Dea, Xinyu Ye, Juan Du, Wei Lü
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Entanglement of nanophotonic quantum memory nodes in a telecom network Nature (IF 64.8) Pub Date : 2024-05-15 C. M. Knaut, A. Suleymanzade, Y.-C. Wei, D. R. Assumpcao, P.-J. Stas, Y. Q. Huan, B. Machielse, E. N. Knall, M. Sutula, G. Baranes, N. Sinclair, C. De-Eknamkul, D. S. Levonian, M. K. Bhaskar, H. Park, M. Lončar, M. D. Lukin
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Engineered CD47 protects T cells for enhanced antitumour immunity Nature (IF 64.8) Pub Date : 2024-05-15 Sean A. Yamada-Hunter, Johanna Theruvath, Brianna J. McIntosh, Katherine A. Freitas, Frank Lin, Molly T. Radosevich, Amaury Leruste, Shaurya Dhingra, Naiara Martinez-Velez, Peng Xu, Jing Huang, Alberto Delaidelli, Moksha H. Desai, Zinaida Good, Roel Polak, Audre May, Louai Labanieh, Jeremy Bjelajac, Tara Murty, Zach Ehlinger, Christopher W. Mount, Yiyun Chen, Sabine Heitzeneder, Kristopher D. Marjon
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Wavefunction matching for solving quantum many-body problems Nature (IF 64.8) Pub Date : 2024-05-15 Serdar Elhatisari, Lukas Bovermann, Yuan-Zhuo Ma, Evgeny Epelbaum, Dillon Frame, Fabian Hildenbrand, Myungkuk Kim, Youngman Kim, Hermann Krebs, Timo A. Lähde, Dean Lee, Ning Li, Bing-Nan Lu, Ulf-G. Meißner, Gautam Rupak, Shihang Shen, Young-Ho Song, Gianluca Stellin
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One-third of Southern Ocean productivity is supported by dust deposition Nature (IF 64.8) Pub Date : 2024-05-15 Jakob Weis, Zanna Chase, Christina Schallenberg, Peter G. Strutton, Andrew R. Bowie, Sonya L. Fiddes
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Decoding the interplay between genetic and non-genetic drivers of metastasis Nature (IF 64.8) Pub Date : 2024-05-15 Panagiotis Karras, James R. M. Black, Nicholas McGranahan, Jean-Christophe Marine
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A renewably sourced, circular photopolymer resin for additive manufacturing Nature (IF 64.8) Pub Date : 2024-05-15 Thiago O. Machado, Connor J. Stubbs, Viviane Chiaradia, Maher A. Alraddadi, Arianna Brandolese, Joshua C. Worch, Andrew P. Dove
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Volatile working memory representations crystallize with practice Nature (IF 64.8) Pub Date : 2024-05-15 Arash Bellafard, Ghazal Namvar, Jonathan C. Kao, Alipasha Vaziri, Peyman Golshani
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Release of a ubiquitin brake activates OsCERK1-triggered immunity in rice Nature (IF 64.8) Pub Date : 2024-05-15 Gang Wang, Xi Chen, Chengzhi Yu, Xiaobao Shi, Wenxian Lan, Chaofeng Gao, Jun Yang, Huiling Dai, Xiaowei Zhang, Huili Zhang, Boyu Zhao, Qi Xie, Nan Yu, Zuhua He, Yu Zhang, Ertao Wang
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Dimerization and antidepressant recognition at noradrenaline transporter Nature (IF 64.8) Pub Date : 2024-05-15 Heng Zhang, Yu-Ling Yin, Antao Dai, Tianwei Zhang, Chao Zhang, Canrong Wu, Wen Hu, Xinheng He, Benxun Pan, Sanshan Jin, Qingning Yuan, Ming-Wei Wang, Dehua Yang, H. Eric Xu, Yi Jiang
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Creation of memory–memory entanglement in a metropolitan quantum network Nature (IF 64.8) Pub Date : 2024-05-15 Jian-Long Liu, Xi-Yu Luo, Yong Yu, Chao-Yang Wang, Bin Wang, Yi Hu, Jun Li, Ming-Yang Zheng, Bo Yao, Zi Yan, Da Teng, Jin-Wei Jiang, Xiao-Bing Liu, Xiu-Ping Xie, Jun Zhang, Qing-He Mao, Xiao Jiang, Qiang Zhang, Xiao-Hui Bao, Jian-Wei Pan
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Dual-action obesity drug rewires brain circuits for appetite Nature (IF 64.8) Pub Date : 2024-05-15 Tyler M. Cook, Darleen Sandoval
Two-in-one drug better than GLP-1 agonist alone at inducing weight loss.
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Strategic links save buildings from total collapse Nature (IF 64.8) Pub Date : 2024-05-15 Sarah L. Orton
Design strategy for preventing failure propagation in buildings.
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‘Quantum internet’ demonstration in cities is most advanced yet Nature (IF 64.8) Pub Date : 2024-05-15
Experiments generate quantum entanglement over optical fibres across three real cities, marking progress towards networks that could have revolutionary applications.
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Experimental obesity drug packs double punch to reduce weight Nature (IF 64.8) Pub Date : 2024-05-15
Test of weight-loss candidate in mice shows that there is still room for improvement in a burgeoning field.
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Parental-care puzzle in mice solved by thinking outside the brain Nature (IF 64.8) Pub Date : 2024-05-15 Jessica Tollkuhn
Previously unknown cell type found in mice that share parental care.
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Lizard-inspired building design could save lives Nature (IF 64.8) Pub Date : 2024-05-15
Hear the biggest stories from the world of science | 15 May 2024
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Effect of the HPV vaccination programme on incidence of cervical cancer and grade 3 cervical intraepithelial neoplasia by socioeconomic deprivation in England: population based observational study BMJ (IF 105.7) Pub Date : 2024-05-15 Milena Falcaro, Kate Soldan, Busani Ndlela, Peter Sasieni
Objectives To replicate previous analyses on the effectiveness of the English human papillomavirus (HPV) vaccination programme on incidence of cervical cancer and grade 3 cervical intraepithelial neoplasia (CIN3) using 12 additional months of follow-up, and to investigate effectiveness across levels of socioeconomic deprivation. Design Observational study. Setting England, UK. Participants Women aged
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Clinical and healthcare use outcomes after cessation of long term opioid treatment due to prescriber workforce exit: quasi-experimental difference-in-differences study BMJ (IF 105.7) Pub Date : 2024-05-16 Adrienne H Sabety, Hannah T Neprash, Marema Gaye, Michael L Barnett
Objective To examine the association between prescriber workforce exit, long term opioid treatment discontinuation, and clinical outcomes. Design Quasi-experimental difference-in-differences study Setting 20% sample of US Medicare beneficiaries, 2011-18. Participants People receiving long term opioid treatment whose prescriber stopped providing office based patient care or exited the workforce, as
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How could a radio broadcast on self-examination have avoided creating misperceptions? BMJ (IF 105.7) Pub Date : 2024-05-16 Richard Smith
Last week I listened to a radio broadcast in which a woman in her 20s with breast cancer described how she examined her breast and found a lump. She is now being treated for breast cancer. The interviewer, an older woman, interviewed her gently with empathy. There was no challenge, as there would have been to a politician, and the result was misleading and probably had some harmful messages. The peg
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Drugs to help adults stop vaping … and other research BMJ (IF 105.7) Pub Date : 2024-05-16 Tom Nolan
Tom Nolan reviews this week’s research Over the past year we’ve seen various trials that assess vaping as an intervention for smoking cessation. Now we have smoking cessation drugs being studied as interventions to help people stop vaping. Cytisinicline, a plant based alkaloid that targets nicotinic acetylcholine receptors, has been available in the UK since the start of this year. One hundred and
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Alasdair Geddes: infectious disease expert and bioterrorism adviser who diagnosed the world’s last reported case of smallpox BMJ (IF 105.7) Pub Date : 2024-05-16 John Illman
Alasdair Geddes recalled that his friends called him “a bit stupid” when he told them he was specialising in infectious disease. “They said, ‘You’re mad. Infectious diseases are disappearing. We have antibiotics and vaccines. Why don’t you do something more interesting?” he explained in the Lancet . Geddes, a modest, quiet but passionate doctor, went on to become president of the International Society
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Protective power of plants . . . and other stories BMJ (IF 105.7) Pub Date : 2024-05-16 British Medical Journal Publishing Group
A longitudinal study of 2000 men with biopsy proved non-metastatic prostate cancer reports benefits from a plant based diet. Diet and lifestyle had been assessed soon after recruitment. During a median follow-up of 6.5 years, men scoring in the highest fifth for dietary intake of grains, fruits, legumes, and vegetables were only half as likely to experience disease progression as those in the lowest
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A boat shaped bleed BMJ (IF 105.7) Pub Date : 2024-05-16 Ming An, Nianting Tong
This is a fundus image of the retina of a woman in her mid 60s with type 2 diabetes who presented with visual disturbances in her left eye (fig 1). She had been diagnosed with diabetes 15 years earlier and had an HbA1c levels consistently …
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New death certification process: welcome changes in mindset, legislation, and hopefully data analysis BMJ (IF 105.7) Pub Date : 2024-05-16 Raj Bhopal
I welcome the renewed emphasis on the prevention of criminal activity as well as routine clinical investigation of the cause of death in the new death certification process.1 The rhetoric around medical murders—that this “must never happen again”—needs to be accompanied by stringent action. When certification of death by doctors was developed in the 19th century ruling out foul play was emphasised
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Private Healthcare Information Network (PHIN): filling data gaps in independent sector BMJ (IF 105.7) Pub Date : 2024-05-16 Christopher Smith-Brown, Richard Wells
As Anderson and colleagues highlight,1 the Private Healthcare Information Network (PHIN) is mandated by the Competition and Markets Authority (CMA) Private Healthcare Investigation Order 20142 to publish performance and fee information about 645 hospitals and 12 000 consultants offering private inpatient services in the UK. We supply information to help patients make informed decisions. We agree that
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“Excited delirium”: can the world lose this controversial term, which is accused of covering up deaths in police custody? BMJ (IF 105.7) Pub Date : 2024-05-15 Chris Stokel-Walker
Updating of medical guidance on the term has been brought forward, The BMJ learns, in the latest sign of the tide turning against its use. Chris Stokel-Walker explores whether “excited delirium” is ever fit for purpose—and what should happen next When George Floyd died in police custody in Minneapolis in May 2020, the circumstances of his death while being restrained became the focus of significant
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HPV vaccine: the key to eliminating cervical cancer inequities BMJ (IF 105.7) Pub Date : 2024-05-15 Trisha L Amboree, Joslyn Paguio, Kalyani Sonawane
Programmes must ensure equitable access for all eligible groups The human papillomavirus (HPV) vaccine protects individuals from HPV strains that cause cancer. Evidence of its effectiveness in eliminating invasive cervical cancers is growing.1234 In a linked paper, Falcaro and colleagues (doi:10.1136/bmj-2023-077341) provide further evidence for the impact of HPV vaccination in eliminating invasive
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Workplace rights around pregnancy and childbirth BMJ (IF 105.7) Pub Date : 2024-05-16 Amy Raub, Jody Heymann
Access to paid leave is a health and equity imperative On 15 April 2024, after a public consultation that received over 100 000 comments, the US Equal Employment Opportunity Commission (EEOC) issued final regulations detailing employers’ obligation to provide reasonable accommodation to pregnant workers.1 These new regulations expand access to unpaid time off as a reasonable accommodation during pregnancy
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Who is accountable for the medical unemployment crisis? BMJ (IF 105.7) Pub Date : 2024-05-16 Kamran Abbasi
The story of vaccination against human papillomavirus in teenage girls is one of success. Cervical cancer rates have dropped markedly in all socioeconomic groups (doi:10.1136/bmj-2023-077341).1 An equitable implementation plan has achieved equitable benefits (doi:10.1136/bmj.q996).2 A less good health story is the murky use of dubious medical labels to deflect from unlawful death. “Excited delirium
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Effectiveness of Bariatric Metabolic Surgery versus Glucagon-Like Peptide-1 Receptor Agonists for prevention of Congestive Heart Failure Nat. Med. (IF 82.9) Pub Date : 2024-05-15 Yael Wolff Sagy, Gil Lavie, Noga Ramot, Erez Battat, Ronen Arbel, Orna Reges, Dror Dicker
Comparative evidence for the effects of bariatric metabolic surgery (BMS) and glucagon-like peptide-1 receptor agonists (GLP1-RA) on cardiovascular outcomes is limited. Here, in an observational, retrospective cohort study, we compared the incidence of Congestive Heart Failure (CHF) in adults living with obesity and diabetes without history of CHF (primary CHF) treated with BMS versus GLP-1RA. The
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The evolution of personalized nutrition Nat. Med. (IF 82.9) Pub Date : 2024-05-15 Josef Neu
Data from a large randomized trial show that a personalized diet can improve cardiometabolic health, providing support for a ‘food as medicine’ concept that, although centuries old, still lacks robust evidence.
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Heat exposure induced risks of preterm birth mediated by maternal hypertension Nat. Med. (IF 82.9) Pub Date : 2024-05-15 Liyun Wang, Jiangli Di, Qiong Wang, Huanhuan Zhang, Wei Zhao, Xiaoming Shi, Qian Di, John S. Ji, Wannian Liang, Cunrui Huang
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Senaparib as first-line maintenance therapy in advanced ovarian cancer: a randomized phase 3 trial Nat. Med. (IF 82.9) Pub Date : 2024-05-15 Xiaohua Wu, Jihong Liu, Jing Wang, Li Wang, Zhongqiu Lin, Xiaobin Wang, Jianqing Zhu, Beihua Kong, Junwei Fei, Ying Tang, Bairong Xia, Zhiqing Liang, Ke Wang, Yi Huang, Hong Zheng, An Lin, Kui Jiang, Wei Wang, Xin Wang, Ge Lou, Hongming Pan, Shuzhong Yao, Guiling Li, Min Hao, Yunlang Cai, Xuejun Chen, Zhijun Yang, Youguo Chen, Hongwu Wen, Pengpeng Qu, Cong Xu, Chih-Yi Hsieh
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I’m worried I’ve been contacted by a predatory publisher — how do I find out? Nature (IF 64.8) Pub Date : 2024-05-15
Researchers frequently receive invitations to publish in journals that they might not have heard of. Nature asked two scientists how they would check whether a publication is legitimate.
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Forestry social science is failing the needs of the people who need it most Nature (IF 64.8) Pub Date : 2024-05-15
Rich nations’ fixation on forests as climate offsets has resulted in the needs of those who live in or make a living from these resources being ignored. A broader view and more collaboration between disciplines is required.
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Explaining novel scientific concepts to people whose technical acumen does not extend to turning it off, then turning it on again Nature (IF 64.8) Pub Date : 2024-05-15
Guided by the light.
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Neglecting sex and gender in research is a public-health risk Nature (IF 64.8) Pub Date : 2024-05-15 Sue Haupt, Cheryl Carcel, Robyn Norton
The data are clear: taking sex and gender into account in research and using that knowledge to change health care could benefit billions of people.
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How to kill the ‘zombie’ cells that make you age Nature (IF 64.8) Pub Date : 2024-05-15
Researchers are using new molecules, engineered immune cells and gene therapy to kill senescent cells and treat age-related diseases.
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2023 summer warmth unparalleled over the past 2,000 years Nature (IF 64.8) Pub Date : 2024-05-14 Jan Esper, Max Torbenson, Ulf Büntgen
Including an exceptionally warm Northern Hemisphere (NH) summer1,2, 2023 has been reported as the hottest year on record3-5. Contextualizing recent anthropogenic warming against past natural variability is nontrivial, however, because the sparse 19th century meteorological records tend to be too warm6. Here, we combine observed and reconstructed June-August (JJA) surface air temperatures to show that
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Africa’s lush tropical forests face a surprising threat: fire Nature (IF 64.8) Pub Date : 2024-05-14
Climate change and deforestation have increased the frequency of blazes in the humid forests of West and Central Africa.
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AI & robotics briefing: Why AI needs to see the ‘ugly’ side of science Nature (IF 64.8) Pub Date : 2024-05-14
The absence of negative results in the scientific literature is affecting AI tools trained on published data. Plus, why animals still outrun robots and AlphaFold gets major upgrade.
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Daily briefing: Amazing auroras are just a warm-up — more solar storms are coming Nature (IF 64.8) Pub Date : 2024-05-14
The upcoming solar maximum means more and bigger solar storms to come. Plus, how to decarbonise the workhorse of fossil fuel production: oil refineries.
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Long acting progestogens versus combined oral contraceptive pill for preventing recurrence of endometriosis related pain: the PRE-EMPT pragmatic, parallel group, open label, randomised controlled trial BMJ (IF 105.7) Pub Date : 2024-05-15 Kevin G Cooper, Siladitya Bhattacharya, Jane P Daniels, Andrew W Horne, T Justin Clark, Ertan Saridogan, Versha Cheed, Danielle Pirie, Melyda Melyda, Mark Monahan, Tracy E Roberts, Emma Cox, Clive Stubbs, Lee J Middleton
Objectives To evaluate the clinical effectiveness of long acting progestogens compared with the combined oral contraceptive pill in preventing recurrence of endometriosis related pain. Design The PRE-EMPT (preventing recurrence of endometriosis) pragmatic, parallel group, open label, randomised controlled trial. Setting 34 UK hospitals. Participants 405 women of reproductive age undergoing conservative
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Equity in medical devices: trainers and educators play a vital role BMJ (IF 105.7) Pub Date : 2024-05-15 Margaret Whitehead, Enitan Carrol, Frank Kee, Raghib Ali, Chris Holmes
Education and training of healthcare professionals is essential to improve the systemwide problem of inequity in medical devices, say Margaret Whitehead and colleagues The impact of racial bias on the performance of medical devices used in the NHS gained public and political attention during the covid pandemic, with the recognition that patients with darker skin tones may be put at increased risk of
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John Launer: Seeing the big picture—the distinctive value of generalism BMJ (IF 105.7) Pub Date : 2024-05-15 John Launer
Patients are often the beneficiaries of medicine, but they can be its victims too. Most people in the western world are likely to know by their 60s that they have at least one chronic condition or risk factor, if not several. As they age further the number of these will almost certainly increase, along with regular check-ups, investigations, and an escalating amount of treatment. Some of the effects
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What do we know about covid-19’s effects on the brain? BMJ (IF 105.7) Pub Date : 2024-05-15 Katharine Lang
Katharine Lang investigates how SARS-CoV-2 infection can affect the brain, how it might have these effects, and what can be done to minimise the risk Covid may be primarily a respiratory infection, but a common symptom is “brain fog”—problems with memory or concentration—which can persist for weeks or months as part of long covid.1 And it’s not the only neurological effect. Giovanni Schifitto, professor