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Neuroanatomical substrates of depression in dementia with Lewy bodies and Alzheimer’s disease

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Abstract

Dementia with Lewy bodies (DLB) and Alzheimer’s disease (AD) are often associated with depressive symptoms from the prodromal stage. The aim of the present study was to investigate the neuroanatomical correlates of depression in prodromal to mild DLB patients compared with AD patients. Eighty-three DLB patients, 37 AD patients, and 18 healthy volunteers were enrolled in this study. Depression was evaluated with the Mini International Neuropsychiatric Interview (MINI), French version 5.0.0. T1-weighted three-dimensional anatomical images were acquired for all participants. Regression and comparison analyses were conducted using a whole-brain voxel-based morphometry (VBM) approach on the grey matter volume (GMV). DLB patients presented a significantly higher mean MINI score than AD patients (p = 0.004), 30.1% of DLB patients had clinical depression, and 56.6% had a history of depression, while 0% of AD patients had clinical depression and 29.7% had a history of depression. VBM regression analyses revealed negative correlations between the MINI score and the GMV of right prefrontal regions in DLB patients (p < 0.001, uncorrected). Comparison analyses between DLB patients taking and those not taking an antidepressant mainly highlighted a decreased GMV in the bilateral middle/inferior temporal gyrus (p < 0.001, uncorrected) in treated DLB patients. In line with the literature, our behavioral analyses revealed higher depression scores in DLB patients than in AD patients. We also showed that depressive symptoms in DLB are associated with decreased GMV in right prefrontal regions. Treated DLB patients with long-standing depression would be more likely to experience GMV loss in the bilateral middle/inferior temporal cortex. These findings should be taken into account when managing DLB patients.

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Data availability

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Acknowledgements

We are grateful to the patients and their relatives and to the healthy control subjects who took part in the present study. The authors also thank the medical doctors of the Memory Center of Strasbourg (CM2R), Pierre Anthony, and Catherine Martin-Hunyadi, the neuropsychologists, Timothée Albasser, Mathias Bilger, Laure Di Bitonto, Emmanuelle Epp-Ehrhard, Guillaume Jung, Jennifer Kemp, Catherine Kleitz, Jeanne Mérignac, Laetitia Monjoin, and Clélie Phillipps, the research clinical assistants, Lucie Rauch and Lea Sanna, as well as the secretary, Gabrielle Huck, for the essential collection of the clinical data. Finally, we would like to thank Vincent Gabriel and Alice Tisserand for their valuable help with image pre-processing and VBM analyses.

Funding

This study was funded by Projet Hospitalier de Recherche Clinique (PHRC) inter-régional (IDRCB 2012-A00992-41).

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Authors and Affiliations

  1. ICube Laboratory UMR 7357 and FMTS (Fédération de Médecine Translationnelle de Strasbourg), IMIS Team University of Strasbourg and CNRS, Strasbourg, France

    Manon Querry, Anne Botzung, Benjamin Cretin, Mary Mondino, Paulo Loureiro de Sousa, Nathalie Philippi & Frédéric Blanc

  2. CM2R (Research and Resources Memory Center), Geriatric Day Hospital, Geriatrics Division, University Hospitals of Strasbourg, Strasbourg, France

    Anne Botzung, Catherine Demuynck, Candice Muller, Alix Ravier, Benoît Schorr, Léa Sanna & Frédéric Blanc

  3. CM2R, Neuropsychology Unit, Neurology Department, Head and Neck Division, University Hospitals of Strasbourg, Strasbourg, France

    Benjamin Cretin & Nathalie Philippi

Authors
  1. Manon Querry
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  2. Anne Botzung
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  3. Benjamin Cretin
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  4. Catherine Demuynck
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  5. Candice Muller
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  7. Benoît Schorr
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  8. Mary Mondino
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  9. Léa Sanna
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  10. Paulo Loureiro de Sousa
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  11. Nathalie Philippi
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  12. Frédéric Blanc
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Contributions

The present study was conceptualized, designed and coordinated by F.B., A.B., and M.Q. M.Q. conducted the behavioural and imaging analyses and wrote the article, while A.B. and F.B. played a major role in revising the manuscript. F.B., N.P., B.C., C.D., C.M., A.R., and B.S. were the medical doctors who carried out the clinical examinations and administered the depression scale, and L.S. was the clinical research assistant who took care of gathering information from medical records (i.e., treatments and medical history). P.LS. was in charge of the acquisition of MRI data, and M.M. was a great help with image pre-processing and VBM analyses. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Manon Querry.

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The authors declare no competing interests.

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Querry, M., Botzung, A., Cretin, B. et al. Neuroanatomical substrates of depression in dementia with Lewy bodies and Alzheimer’s disease. GeroScience (2024). https://doi.org/10.1007/s11357-024-01190-4

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