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Limits of economy and fidelity for programmable assembly of size-controlled triply periodic polyhedra Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-04-26 Carlos M. DuqueDouglas M. HallBotond TyukodiMichael F. HaganChristian D. SantangeloGregory M. GrasonaMax Planck Institute of Molecular Cell Biology and Genetics, Dresden 01307, GermanybCenter for Systems Biology Dresden, Dresden 01307, GermanycDepartment of Physics, University of Massachusetts, Amherst, MA 01003dDepartment of Polymer Science and Engineering, University of Massachusetts, Amherst, MA
Proceedings of the National Academy of Sciences, Volume 121, Issue 18, April 2024.
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Dissection and integration of bursty transcriptional dynamics for complex systems Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-04-26 Cheng Frank GaoSuriyanarayanan VaikuntanathanSamantha J. RiesenfeldaDepartment of Chemistry, University of Chicago, Chicago, IL 60637bInstitute for Biophysical Dynamics, University of Chicago, Chicago, IL 60637cPritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637dDepartment of Medicine, University of Chicago, Chicago, IL 60637eCommittee on Immunology, Biological Sciences
Proceedings of the National Academy of Sciences, Volume 121, Issue 18, April 2024.
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Core planar cell polarity genes VANGL1 and VANGL2 in predisposition to congenital vertebral malformations Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-04-26 Xin FengYongyu YeJianan ZhangYuanqiang ZhangSen ZhaoJudith C. W. MakNao OtomoZhengye ZhaoYuchen NiuYoshiro YonezawaGuozhuang LiMao LinXiaoxin LiPrudence Wing Hang CheungKexin XuKazuki TakedaShengru WangJunjie XieToshiaki KotaniVanessa N. T. ChoiYou-Qiang SongYang YangKeith Dip Kei LukKin Shing LeeZiquan LiPik Shan LiConnie Y. H. LeungXiaochen LinXiaolu WangGuixing QiuKota WatanabeZhihong WuJennifer
Proceedings of the National Academy of Sciences, Volume 121, Issue 18, April 2024.
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Negative correlation between soil salinity and soil organic carbon variability Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-04-26 Amirhossein HassaniPete SmithNima ShokriaThe Climate and Environmental Research Institute NILU, Kjeller 2027, NorwaybInstitute of Biological and Environmental Sciences, School of Biological Sciences, University of Aberdeen, Aberdeen AB24 3UU, United KingdomcInstitute of Geo-Hydroinformatics, Hamburg University of Technology, 21073 Hamburg, Germany
Proceedings of the National Academy of Sciences, Volume 121, Issue 18, April 2024.
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Cryo-EM reveals a nearly complete PCNA loading process and unique features of the human alternative clamp loader CTF18-RFC Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-04-26 Qing HeFeng WangMichael E. O’DonnellHuilin LiaDepartment of Structural Biology, Van Andel Institute, Grand Rapids, MI 49503bDNA Replication Laboratory, The Rockefeller University, New York, NY 10065cHHMI, The Rockefeller University, New York, NY 10065
Proceedings of the National Academy of Sciences, Volume 121, Issue 18, April 2024.
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Machine learning enables identification of an alternative yeast galactose utilization pathway Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-04-26 Marie-Claire HarrisonEmily J. UbbelohdeAbigail L. LaBellaDana A. OpulenteJohn F. WoltersXiaofan ZhouXing-Xing ShenMarizeth GroenewaldChris Todd HittingerAntonis RokasaDepartment of Biological Sciences and Evolutionary Studies Initiative, Vanderbilt University, Nashville, TN 37235bLaboratory of Genetics, Department of Energy (DOE) Great Lakes Bioenergy Research Center, Center for Genomic Science Innovation
Proceedings of the National Academy of Sciences, Volume 121, Issue 18, April 2024.
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Structural rearrangements in the nucleus localize latent HIV proviruses to a perinucleolar compartment supportive of reactivation Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-04-26 Fredrick KizitoKien NguyenUri MbonyeMeenakshi ShuklaBenjamin LuttgeMary Ann CheckleyAnna AgaponovaKonstantin LeskovJonathan KarnaDepartment of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106
Proceedings of the National Academy of Sciences, Volume 121, Issue 18, April 2024.
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How I’m supporting other researchers who have moved to Lithuania Nature (IF 64.8) Pub Date : 2024-05-01
Biochemist Stephen Knox Jones chose a role in the Baltic country over other faculty positions in Denmark and the United States. He explains why.
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Chinese virologist who was first to share COVID genome sleeps on street after lab shuts Nature (IF 64.8) Pub Date : 2024-05-01
Zhang Yongzhen shared the genomic sequence of SARS-CoV-2 with the world, speeding the development of vaccines.
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Plagiarism in peer-review reports could be the ‘tip of the iceberg’ Nature (IF 64.8) Pub Date : 2024-05-01
Researchers say swathe of copied text could indicate a widespread problem.
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Scientists tried to give people COVID — and failed Nature (IF 64.8) Pub Date : 2024-05-01
Researchers deliberately infect participants with SARS-CoV-2 in ‘challenge’ trials — but high levels of immunity complicate efforts to test vaccines and treatments.
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I fell out of love with the lab, and in love with business Nature (IF 64.8) Pub Date : 2024-05-01
The COVID-19 pandemic changed Karolina Makovskytė’s career ambitions, propelling her to a business development role in her home nation of Lithuania.
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How to meet Africa’s grand challenges with African know-how Nature (IF 64.8) Pub Date : 2024-05-01
Simple measures to strengthen the interface between science, policy and society in African nations could help the continent leapfrog others in sustainable innovation and development.
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How bioinformatics led one scientist home to Lithuania Nature (IF 64.8) Pub Date : 2024-05-01
Juozas Gordevičius founded a data-science company in the United States before returning to Vilnius.
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A snapshot of Lithuania’s life-sciences landscape Nature (IF 64.8) Pub Date : 2024-05-01
Nature examines the Baltic country’s research ambitions as it marks 20 years of European Union membership.
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Support communities that will lose out in the energy transition Nature (IF 64.8) Pub Date : 2024-05-01
Climate campaigners and politicians rightly concentrate on the benefits of clean energy — but without more support for those who are adversely affected, the backlash will only grow.
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Not just truffles: dogs can sniff out surpassingly rare native fungus Nature (IF 64.8) Pub Date : 2024-04-30
Daisy, a member of a breed used to find fungal delicacies, detected a critically endangered Australian fungus faster than a trained human could.
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AI & robotics briefing: What running robots tell us about gaits Nature (IF 64.8) Pub Date : 2024-04-30
A robot that changes from trot to bounce to avoid falls hints at why four-legged animals transition between gaits. Plus, AI designs new gene-editing tools and how autonomous weapons are changing war.
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The science of 3 Body Problem: what’s fact and what’s fiction? Nature (IF 64.8) Pub Date : 2024-04-30
Nature spoke to the sci-fi program’s adviser and two other researchers about the portrayal of PhD scientists and their technologies.
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This social sciences hub galvanized India’s dynamic growth. Can it survive? Nature (IF 64.8) Pub Date : 2024-04-30
The Centre for Policy Research has lost its chief executive, most of its staff and is running out of cash.
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Multimodal decoding of human liver regeneration Nature (IF 64.8) Pub Date : 2024-05-01 K. P. Matchett, J. R. Wilson-Kanamori, J. R. Portman, C. A. Kapourani, F. Fercoq, S. May, E. Zajdel, M. Beltran, E. F. Sutherland, J. B. G. Mackey, M. Brice, G. C. Wilson, S. J. Wallace, L. Kitto, N. T. Younger, R. Dobie, D. J. Mole, G. C. Oniscu, S. J. Wigmore, P. Ramachandran, C. A. Vallejos, N. O. Carragher, M. M. Saeidinejad, A. Quaglia, R. Jalan, K. J. Simpson, T. J. Kendall, J. A. Rule, W. M
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Stereoselective amino acid synthesis by photobiocatalytic oxidative coupling Nature (IF 64.8) Pub Date : 2024-05-01 Tian-Ci Wang, Binh Khanh Mai, Zheng Zhang, Zhiyu Bo, Jiedong Li, Peng Liu, Yang Yang
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Endurance exercise causes a multi-organ full-body molecular reaction Nature (IF 64.8) Pub Date : 2024-05-01
Stay on that treadmill to benefit every organ in your body.
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Intel brings quantum-computing microchips a step closer Nature (IF 64.8) Pub Date : 2024-05-01 Ruoyu Li
Silicon qubits fabricated on a 300-mm wafer.
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We need more-nuanced approaches to exploring sex and gender in research Nature (IF 64.8) Pub Date : 2024-05-01 Stacey A. Ritz, Lorraine Greaves
Some scientists are reluctant to investigate questions about sex and gender, particularly given today’s sociopolitical tensions around gender identity. But they should lean in and embrace the complexity.
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Why it’s essential to study sex and gender, even as tensions rise Nature (IF 64.8) Pub Date : 2024-05-01
Some scholars are reluctant to research sex and gender out of fear that their studies will be misused. In a series of specially commissioned articles, Nature encourages scientists to engage.
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Genomics reveal unknown mutation-promoting agents at global sites Nature (IF 64.8) Pub Date : 2024-05-01 Irene Franco, Fran Supek
Cancer-sequence signatures point to unknown mutation-promoting agents.
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Male–female comparisons are powerful in biomedical research — don’t abandon them Nature (IF 64.8) Pub Date : 2024-05-01 Arthur P. Arnold, Sabra L. Klein, Margaret M. McCarthy, Jeffrey S. Mogil
Binary sex studies have been denounced as too simplistic, but dropping them altogether would impede progress in a long-neglected area of biomedicine.
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Cells destroy donated mitochondria to build blood vessels Nature (IF 64.8) Pub Date : 2024-05-01 Chantell S. Evans
Mitochondrial transfer enhances endothelial-cell grafts.
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Why is exercise good for you? Scientists are finding answers in our cells Nature (IF 64.8) Pub Date : 2024-05-01
Decades of evidence shows that exercise leads to healthier, longer lives. Researchers are just starting to work out what it does to cells to reap this reward.
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Resilience lessons from ancient societies are still relevant today Nature (IF 64.8) Pub Date : 2024-05-01 John Haldon
Long-term global analysis reveals what makes human populations resilient.
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Dad’s gut microbes matter for pregnancy health and baby’s growth Nature (IF 64.8) Pub Date : 2024-05-01 Liisa Veerus, Martin J. Blaser, Yoel Sadovsky, Eldin Jašarević
Parental gut microbes boost offspring health and development of placenta.
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In This Issue Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-04-30
Proceedings of the National Academy of Sciences, Volume 121, Issue 18, April 2024.
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Why it was right to reject the Anthropocene as a geological epoch Nature (IF 64.8) Pub Date : 2024-04-30
Letter to the Editor
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How to stop students cramming for exams? Send them to sea Nature (IF 64.8) Pub Date : 2024-04-30
Snippets from Nature’s past.
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Corrosion is a global menace to crucial infrastructure — act to stop the rot now Nature (IF 64.8) Pub Date : 2024-04-30
Letter to the Editor
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Zoos should focus on animal welfare before claiming to champion conservation Nature (IF 64.8) Pub Date : 2024-04-30
Letter to the Editor
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Climate-targets group should rescind its endorsement of carbon offsets Nature (IF 64.8) Pub Date : 2024-04-30
Letter to the Editor
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First fetus-to-fetus transplant demonstrated in rats Nature (IF 64.8) Pub Date : 2024-04-30
The tissue developed into functioning kidneys and produced urine.
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What China’s mission to collect rocks from the far side could reveal about the Moon Nature (IF 64.8) Pub Date : 2024-04-30
The Chang’e-6 mission aims to land in the Moon’s oldest and largest crater, collect rocks, and bring them back to Earth.
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Why doing science is difficult in India today Nature (IF 64.8) Pub Date : 2024-04-30
With an election under way, the future of Indian science is on the ballot. Encouraging research and critical thinking should be a priority for the new government.
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Do cutting-edge CAR-T-cell therapies cause cancer? What the data say Nature (IF 64.8) Pub Date : 2024-04-30
Regulators have identified around 30 cases of cancer linked to this blockbuster treatment. But is CAR T to blame? The hunt is on for answers.
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Epic blazes threaten Arctic permafrost. Can fire-fighters save it? Nature (IF 64.8) Pub Date : 2024-04-29
Some scientists argue that it’s time to rethink the blanket policy of letting blazes burn themselves out in northern wildernesses.
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How reliable is this research? Tool flags papers discussed on PubPeer Nature (IF 64.8) Pub Date : 2024-04-29
Browser plug-in alerts users when studies — or their references — have been posted on a site known for raising integrity concerns.
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‘ChatGPT for CRISPR’ creates new gene-editing tools Nature (IF 64.8) Pub Date : 2024-04-29
Some of the AI-designed gene editors could be more versatile than those found in nature.
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Tailoring atomic chemistry to refine reaction pathway for the most enhancement by magnetization in water oxidation Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-04-30 Tianze Wu, Jingjie Ge, Qian Wu, Xiao Ren, Fanxu Meng, Jiarui Wang, Shibo Xi, Xin Wang, Kamal Elouarzaki, Adrian Fisher, Zhichuan J. Xu
Water oxidation on magnetic catalysts has generated significant interest due to the spin-polarization effect. Recent studies have revealed that the disappearance of magnetic domain wall upon magnetization is responsible for the observed oxygen evolution reaction (OER) enhancement. However, an atomic picture of the reaction pathway remains unclear, i.e., which reaction pathway benefits most from spin-polarization
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Deficiency of IL-22–binding protein enhances the ability of the gut microbiota to protect against enteric pathogens Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-04-30 José L. Fachi, Blanda Di Luccia, Susan Gilfillan, Hao-Wei Chang, Christina Song, Jiye Cheng, Marina Cella, Marco Aurelio Vinolo, Jeffrey I. Gordon, Marco Colonna
Interleukin 22 (IL-22) promotes intestinal barrier integrity, stimulating epithelial cells to enact defense mechanisms against enteric infections, including the production of antimicrobial peptides. IL-22 binding protein (IL-22BP) is a soluble decoy encoded by the Il22ra2 gene that decreases IL-22 bioavailability, attenuating IL-22 signaling. The impact of IL-22BP on gut microbiota composition and
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Dermonecrosis caused by a spitting cobra snakebite results from toxin potentiation and is prevented by the repurposed drug varespladib Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-04-30 Keirah E. Bartlett, Steven R. Hall, Sean A. Rasmussen, Edouard Crittenden, Charlotte A. Dawson, Laura-Oana Albulescu, William Laprade, Robert A. Harrison, Anthony J. Saviola, Cassandra M. Modahl, Timothy P. Jenkins, Mark C. Wilkinson, José María Gutiérrez, Nicholas R. Casewell
Snakebite envenoming is a neglected tropical disease that causes substantial mortality and morbidity globally. The venom of African spitting cobras often causes permanent injury via tissue-destructive dermonecrosis at the bite site, which is ineffectively treated by current antivenoms. To address this therapeutic gap, we identified the etiological venom toxins in Naja nigricollis venom responsible
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Tailored UPRE2 variants for dynamic gene regulation in yeast Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-04-30 Chufan Xiao, Xiufang Liu, Yuyang Pan, Yanling Li, Ling Qin, Zhibo Yan, Yunzi Feng, Mouming Zhao, Mingtao Huang
Genetic elements are foundational in synthetic biology serving as vital building blocks. They enable programming host cells for efficient production of valuable chemicals and recombinant proteins. The unfolded protein response (UPR) is a stress pathway in which the transcription factor Hac1 interacts with the upstream unfolded protein response element (UPRE) of the promoter to restore endoplasmic reticulum
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Transient Zn 2+ deficiency induces replication stress and compromises daughter cell proliferation Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-04-30 Samuel E. Holtzen, Elnaz Navid, Joseph D. Kainov, Amy E. Palmer
Cells must replicate their genome quickly and accurately, and they require metabolites and cofactors to do so. Ionic zinc (Zn 2+ ) is an essential micronutrient that is required for hundreds of cellular processes, including DNA synthesis and adequate proliferation. Deficiency in this micronutrient impairs DNA synthesis and inhibits proliferation, but the mechanism is unknown. Using fluorescent reporters
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Development of porcine skeletal muscle extracellular matrix–derived hydrogels with improved properties and low immunogenicity Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-04-30 Mohammed A. Barajaa, Takayoshi Otsuka, Debolina Ghosh, Ho-Man Kan, Cato T. Laurencin
Hydrogels derived from decellularized extracellular matrices (ECM) of animal origin show immense potential for regenerative applications due to their excellent cytocompatibility and biomimetic properties. Despite these benefits, the impact of decellularization protocols on the properties and immunogenicity of these hydrogels remains relatively unexplored. In this study, porcine skeletal muscle ECM
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Robust inference of causality in high-dimensional dynamical processes from the Information Imbalance of distance ranks Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-04-30 Vittorio Del Tatto, Gianfranco Fortunato, Domenica Bueti, Alessandro Laio
We introduce an approach which allows detecting causal relationships between variables for which the time evolution is available. Causality is assessed by a variational scheme based on the Information Imbalance of distance ranks, a statistical test capable of inferring the relative information content of different distance measures. We test whether the predictability of a putative driven system Y can
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CCR3-dependent eosinophil recruitment is regulated by sialyltransferase ST3Gal-IV Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-04-30 Roland Immler, Katrin Nussbaumer, Axel Doerner, Omar El Bounkari, Silke Huber, Janine Abisch, Matteo Napoli, Sarah Schmidt, Andreas Margraf, Monika Pruenster, Ina Rohwedder, Baerbel Lange-Sperandio, Marcus A. Mall, Renske de Jong, Caspar Ohnmacht, Juergen Bernhagen, David Voehringer, Jamey D. Marth, David Frommhold, Markus Sperandio
Eosinophil recruitment is a pathological hallmark of many allergic and helminthic diseases. Here, we investigated chemokine receptor CCR3-induced eosinophil recruitment in sialyltransferase St3gal4 −/− mice. We found a marked decrease in eosinophil extravasation into CCL11-stimulated cremaster muscles and into the inflamed peritoneal cavity of St3gal4 −/− mice. Ex vivo flow chamber assays uncovered
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Structural insights into human MHC-II association with invariant chain Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-04-30 Nan Wang, Deepa Waghray, Nathanael A. Caveney, Kevin M. Jude, K. Christopher Garcia
The loading of processed peptides on to major histocompatibility complex II (MHC-II) molecules for recognition by T cells is vital to cell-mediated adaptive immunity. As part of this process, MHC-II associates with the invariant chain (Ii) during biosynthesis in the endoplasmic reticulum to prevent premature peptide loading and to serve as a scaffold for subsequent proteolytic processing into MHC-II-CLIP
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Detecting inbreeding depression in structured populations Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-04-30 Eléonore Lavanchy, Bruce S. Weir, Jérôme Goudet
Measuring inbreeding and its consequences on fitness is central for many areas in biology including human genetics and the conservation of endangered species. However, there is no consensus on the best method, neither for quantification of inbreeding itself nor for the model to estimate its effect on specific traits. We simulated traits based on simulated genomes from a large pedigree and empirical
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Localizing somatic symptoms associated with childhood maltreatment Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-04-30 Ethan G. Dutcher, Sara C. Verosky, Wendy Berry Mendes, Stefanie E. Mayer
Childhood maltreatment has been linked to adult somatic symptoms, although this has rarely been examined in daily life. Furthermore, the localization of somatization associated with childhood maltreatment and its subtypes is unknown. This large-scale experience sampling study used body maps to examine the relationships between childhood maltreatment, its subtypes, and the intensity and location of
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Identification and epidemiological study of an uncultured flavivirus from ticks using viral metagenomics and pseudoinfectious viral particles Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-04-30 Daisuke Kobayashi, Yusuke Inoue, Ryosuke Suzuki, Mami Matsuda, Hiroshi Shimoda, Astri Nur Faizah, Yoshihiro Kaku, Keita Ishijima, Yudai Kuroda, Kango Tatemoto, Milagros Virhuez-Mendoza, Michiko Harada, Ayano Nishino, Mizue Inumaru, Kenzo Yonemitsu, Ryusei Kuwata, Ai Takano, Mamoru Watanabe, Yukiko Higa, Kyoko Sawabe, Ken Maeda, Haruhiko Isawa
During their blood-feeding process, ticks are known to transmit various viruses to vertebrates, including humans. Recent viral metagenomic analyses using next-generation sequencing (NGS) have revealed that blood-feeding arthropods like ticks harbor a large diversity of viruses. However, many of these viruses have not been isolated or cultured, and their basic characteristics remain unknown. This study
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An essential and highly selective protein import pathway encoded by nucleus-forming phage Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-04-30 Chase J. Morgan, Eray Enustun, Emily G. Armbruster, Erica A. Birkholz, Amy Prichard, Taylor Forman, Ann Aindow, Wichanan Wannasrichan, Sela Peters, Koe Inlow, Isabelle L. Shepherd, Alma Razavilar, Vorrapon Chaikeeratisak, Benjamin A. Adler, Brady F. Cress, Jennifer A. Doudna, Kit Pogliano, Elizabeth Villa, Kevin D. Corbett, Joe Pogliano
Targeting proteins to specific subcellular destinations is essential in prokaryotes, eukaryotes, and the viruses that infect them. Chimalliviridae phages encapsulate their genomes in a nucleus-like replication compartment composed of the protein chimallin (ChmA) that excludes ribosomes and decouples transcription from translation. These phages selectively partition proteins between the phage nucleus
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Myospreader improves gene editing in skeletal muscle by myonuclear propagation Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-04-30 Kiril K. Poukalov, M. Carmen Valero, Derek R. Muscato, Leanne M. Adams, Heejae Chun, Young il Lee, Nadja S. Andrade, Zane Zeier, H. Lee Sweeney, Eric T. Wang
Successful CRISPR/Cas9-based gene editing in skeletal muscle is dependent on efficient propagation of Cas9 to all myonuclei in the myofiber. However, nuclear-targeted gene therapy cargos are strongly restricted to their myonuclear domain of origin. By screening nuclear localization signals and nuclear export signals, we identify “Myospreader,” a combination of short peptide sequences that promotes