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A systematic review/meta‐analysis of prevalence and incidence rates illustrates systemic underrepresentation of individuals racialized as Asian and/or Asian‐American in ADRD research
Alzheimer's & Dementia ( IF 14.0 ) Pub Date : 2024-05-06 , DOI: 10.1002/alz.13820
Yiqi Zhu 1 , Soobin Park 2 , Ramana Kolady 3 , Wenqing Zha 4 , Ying Ma 5 , Amanda Dias 1 , Katherine McGuire 1 , Angela Hardi 6 , Sunny Lin 7 , Zahinoor Ismail 8, 9 , Paris B. Adkins‐Jackson 10 , Jean‐Francois Trani 2, 11, 12, 13 , Ganesh M. Babulal 4, 11, 13, 14
Affiliation  

We investigate Alzheimer's disease and related dementia (ADRD) prevalence, incidence rate, and risk factors in individuals racialized as Asian and/or Asian‐American and assess sample representation. Prevalence, incidence rate, risk factors, and heterogeneity of samples were assessed. Random‐effects meta‐analysis was conducted, generating pooled estimates. Of 920 records across 14 databases, 45 studies were included. Individuals racialized as Asian and/or Asian‐American were mainly from Eastern and Southern Asia, had higher education, and constituted a smaller sample relative to non‐Hispanic white cohorts. The average prevalence was 10.9%, ranging from 0.4% to 46%. The average incidence rate was 20.03 (12.01‐33.8) per 1000 person‐years with a range of 75.19–13.59 (12.89‐14.33). Risk factors included physiological, genetic, psychological, behavioral, and social factors. This review underscores the systemic underrepresentation of individuals racialized as Asian and/or Asian‐American in ADRD research and the need for inclusive approaches accounting for culture, language, and immigration status.Highlights There is considerable heterogeneity in the prevalence of ADRD among studies of Asian‐Americans. There is limited data on group‐specific risk factors for ADRD among Asian–Americans. The average prevalence of (ADRD) among Asian–Americans was found to be 7.4%, with a wide range from 0.5% to 46%.

中文翻译:

对患病率和发病率的系统回顾/荟萃分析表明,在 ADRD 研究中,亚裔和/或亚裔美国人的种族代表性不足

我们调查了亚裔和/或亚裔美国人中阿尔茨海默病和相关痴呆 (ADRD) 的患病率、发病率和危险因素,并评估了样本代表性。评估了样本的患病率、发病率、危险因素和异质性。进行随机效应荟萃分析,生成汇总估计值。在 14 个数据库的 920 条记录中,纳入了 45 项研究。被种族化为亚裔和/或亚裔美国人的个人主要来自东亚和南亚,受过高等教育,并且相对于非西班牙裔白人群体而言,样本规模较小。平均患病率为10.9%,范围为0.4%至46%。平均发病率为每1000人年20.03(12.01-33.8),范围为75.19-13.59(12.89-14.33)。危险因素包括生理、遗传、心理、行为和社会因素。本综述强调了 ADRD 研究中被种族化为亚裔和/或亚裔美国人的个体的系统性代表性不足,以及需要采用包容性方法来解释文化、语言和移民身份。 对亚裔美国人的研究中 ADRD 患病率存在​​相当大的异质性。 关于亚裔美国人 ADRD 的特定群体危险因素的数据有限。 亚裔美国人 (ADRD) 的平均患病率为 7.4%,范围从 0.5% 到 46% 不等。
更新日期:2024-05-06
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