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Evaluation of genotoxic damage, production reactive oxygen and nitrogen species in Plasmodium yoelii yoelii exposed to sodium metavanadate Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-05-09 Brenda Casarrubias-Tabarez, Norma Rivera-Fernández, Norberto Alarcón-Herrera, Gabriela Guerrero-Palomo, Marcela Rojas-Lemus, Nelly López-Valdez, Jhony Anacleto-Santos, Adriana Gonzalez-Villalva, Martha Ustarroz-Cano, Teresa I. Fortoul
Malaria represents the greatest global health burden among all parasitic diseases, with drug resistance representing the primary obstacle to control efforts. Sodium metavanadate (NaVO) exhibits antimalarial activity against the Plasmodium (), yet its precise antimalarial mechanism remains elusive. This study aimed to assess the antimalarial potential of NaVO, evaluate its genotoxicity, and determine
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Associations between exposure to phthalates and liver function among women undergoing assisted reproductive technology Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-05-09 Yi Wang, Li Yin, Yao-Yao Du, Hong-Mei Liao, Juan Li, Wen Yao, Xiao-Qiong Yuan, Qing-Chun Guo, Tao-Ran Deng, Na Guo, Min Zhang, Qiang Zeng, Chong Liu, Yu-Feng Li
Phthalates can induce hepatotoxicity in animal studies. We aimed to assess the associations of individual and mixture of urinary phthalate metabolites with serum liver function indicators among 764 women undergoing assisted reproductive technology (ART). In linear models, we observed inverse correlations between urinary mono-benzyl phthalate and serum total protein (TP) as well as globulin (β=–0.27
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Polycyclic aromatic hydrocarbons exposure and arterial stiffness-related plasma miRNAs: A panel study Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-05-08 Ziqian Zhang, Conghua Bai, Lei Zhao, Linlin Liu, Wenting Guo, Miao Liu, Huihua Yang, Xuefeng Lai, Xiaomin Zhang, Liangle Yang
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Genetic alteration profiling in middle-aged women acutely exposed during the mechanical processing of dental nanocomposites Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-05-06 Andrea Rossnerova, Irena Chvojkova, Fatima Elzeinova, Daniela Pelclova, Pavlina Klusackova, Vladimir Zdimal, Lucie Ondrackova, Pavel Bradna, Adela Roubickova, Zuzana Simova, Pavel Rossner Jr.
Nanoparticles (NPs) have become an important part of everyday life, including their application in dentistry. Aside from their undoubted benefits, questions regarding their risk to human health, and/or genome have arisen. However, studies concerning cytogenetic effects are completely absent. A group of women acutely exposed to an aerosol released during dental nanocomposite grinding was sampled before
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Toxic heavy metals in a landfill environment (Vientiane, Laos): Fish species and associated health risk assessment Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-05-03 Vongdala Noudeng, Dek Vimean Pheakdey, Tran Dang Xuan
Leachates from municipal landfills introduce toxic heavy metals into water, causing bioaccumulation. This study assesses metal levels and potential human health risks associated with consuming and . Inductively coupled plasma mass spectrometry detected Cd, Cu, Cr, Ni, Pb, and Zn in both fish species. Leachate metal concentrations meet international discharge standards, Cd, Cr, and Pb in the fish exceed
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Occupational second-hand smoke exposure: A comparative shotgun proteomics study on nasal epithelia from healthy restaurant workers Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-04-27 Sofia Neves, Solange Pacheco, Fátima Vaz, Peter James, Tânia Simões, Deborah Penque
Non-smokers exposed to second-hand smoke (SHS) present risk of developing tobacco smoke-associated pathologies. To investigate the airway molecular response to SHS exposure that could be used in health risk assessment, comparative shotgun proteomics was performed on nasal epithelium from a group of healthy restaurant workers, non-smokers (never and former) exposed and not exposed to SHS in the workplace
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Phthalate esters in clothing: A review Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-04-25 Natalia Aldegunde-Louzao, Manuel Lolo-Aira, Carlos Herrero-Latorre
Phthalate esters (PAEs) are widely used as plasticizers to enhance the flexibility and durability of different consumer products, including clothing. However, concerns have been raised about the potential adverse health effects associated with the presence of phthalates in textiles, such as endocrine disruption, reproductive toxicity and potential carcinogenicity. Based on examination of more than
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A multi-approach analysis of the toxicity of a commercial formulation of monensin on Rhinella arenarum embryos and larvae Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-04-24 Julieta Peluso, Agostina Martínez Chehda, Carolina M. Aronzon
Monensin, an antibacterial commonly used in animal fattening, can enter aquatic ecosystems and harm non-target organisms. Since there are no previous studies about the effects of monensin on amphibians, the aim of the present study was to evaluate the lethal and sublethal toxicity of a commercial formulation of monensin (CFM) through standardized bioassays with embryos and larvae of the amphibian
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Biopesticide spinosad: Unraveling ecotoxicological effects on zebrafish, Danio rerio Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-04-23 Inês Amaral, Sara C. Antunes, Daniela Rebelo, António Paulo Carvalho, Sara Rodrigues
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Exposure to heavy metals, antioxidant status, and the interaction of single nucleotide polymorphisms in the genes CAT rs7943316, GSTP1 rs1695, as well as GSTM1 and GSTT1 genes, among workers in occupational settings Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-04-23 Sosan Andleeb Khan, Syed Muhammad Nurulain, Rashid Nazir Qureshi, Amina Zafar, Zarish Riaz, Aneela Shoukat, Zahid Muneer, Nazia Bibi, Saqlain Raza, Sabir Hussain, Syed Tahir Abbas Shah
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Exposure to environmental pollutants and genetic variants related to oxidative stress and xenobiotic metabolism—Association with prostate cancer Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-04-23 Beatriz Álvarez-González, Antonio F. Hernández, Alberto Zafra-Gómez, Lucia Chica-Redecillas, Sergio Cuenca-López, Fernando Vázquez-Alonso, Luis Javier Martínez-González, María Jesús Álvarez-Cubero
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Modulating responses of indicator genes in cellular homeostasis, immune defense and apoptotic process in the Macrophthalmus japonicus exposed to di(2-ethylhexyl) phthalate as a plastic additive Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-04-22 Kiyun Park, Ihn-Sil Kwak
Di(2-ethylhexyl) phthalate (DEHP), have been increasingly used as plasticizers to manufacture soft and flexible materials and ubiquitously found in water and sediments in the aquatic ecosystem. The aim of the present study was to evaluate the effect of DEHP exposure on cellular homeostasis ( and seven ), immune responses (), and apoptotic responses (, , ). DEHP exposure upregulated the expression of
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Aluminum and ABC transporter activity Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-04-20 Goezde Oezen, Lisa Kraus, Eva-Maria Schentarra, Jan Stephan Bolten, Joerg Huwyler, Gert Fricker
Aluminum is the third most common element on Earth´s crust and despite its wide use in our workaday life it has been associated with several health risks after overexposure. In the present study the impact of aluminum salts upon ABC transporter activity was studied in the P-GP-expressing human blood-brain barrier cell line hCMEC/D3, in MDCKII cells overexpressing BCRP and MRP2, respectively, and in
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Antagonistic effects of a COX1/2 inhibitor drug in human HepG2 cells exposed to an environmental carcinogen Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-04-18 Carla Martins, Marcos Felipe de Oliveira Galvão, Pedro M. Costa, Kristian Dreij
Understanding interactions between legacy and emerging environmental contaminants has important implications for risk assessment, especially when mutagens and carcinogens are involved, whose critical effects are chronic and therefore difficult to predict. The current work aimed to investigate potential interactions between benzo[]pyrene (B[]P), a carcinogenic polycyclic aromatic hydrocarbon and legacy
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Genotoxic effect of two environmentally safe doses of cadmium on the hepato-nephrocytic system of Bombus atratus forager workers Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-04-16 Guilherme Andrade Neto Schmitz Boeing, Michele Provase, Elisabete Tsukada, Raquel F. Salla, Fabio Camargo Abdalla
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DNA modifications: Biomarkers for the exposome? Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-04-16 Carolina Möller, Jazmine Virzi, Yuan-Jhe Chang, Alexandra Keidel, Mu-Rong Chao, Chiung-Wen Hu, Marcus S. Cooke
The concept of the exposome is the encompassing of all the environmental exposures, both exogenous and endogenous, across the life course. Many, if not all, of these exposures can result in the generation of reactive species, and/or the modulation of cellular processes, that can lead to a breadth of modifications of DNA, the nature of which may be used to infer their origin. Because of their role in
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Comprehensive analysis of prohibited substances and methods in sports: Unveiling trends, pharmacokinetics, and WADA evolution Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-04-16 Patrik Oleksak, Eugenie Nepovimova, Marian Valko, Saleh Alwasel, Suliman Alomar, Kamil Kuca
This review systematically compiles sports-related drugs, substances, and methodologies based on the most frequently detected findings from prohibited lists published annually by the World Anti-Doping Agency (WADA) between 2003 and 2021. Aligned with structure of the 2023 prohibited list, it covers all proscribed items and details the pharmacokinetics and pharmacodynamics of five representatives from
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UV-aged polystyrene nanoplastics aggravate intestinal barrier damage by overproduction of ROS Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-04-12 Tianjiang Jia, Jin Cai, Shiyu He, Zhen Mao, Xiaodan Zhang, Aobo Geng, Hong Yang, Shuqin Jiang, Peili Huang
UV irradiation significantly alters nanoplastics (NPs) physicochemical properties, thus affecting their biological toxicity. This study is the first to assess the influence of virgin and UV-aged polystyrene NPs (v-PS NPs, a-PS NPs) on the intestinal barrier of ICR mice. We found that a-PS NPs can cause more severe intestinal barrier damage compared with v-PS NPs. The reason may be attributed to that
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Evaluation of acute toxicity of an emerging contaminant Oxybenzone on an ecologically important aquatic macrophyte Lemna minor Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-04-10 Shamika Shantaram Sawant, Vidya Shree Bharti, Satya Prakash Shukla, Kundan Kumar, G. Rathi Bhuvaneswari
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Nanoplastics aggravated TDCIPP-induced transgenerational developmental neurotoxicity in zebrafish depending on the involvement of the dopamine signaling pathway Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-04-09 Xin Ren, Zhibo Liu, Ruiqi Zhang, Yuting Shao, Xiaoyue Duan, Bo Sun, Xuesong Zhao
Plastics pose a hazard to the environment. Although plastics have toxicity, microplastics (MPs) and nanoplastics (NPs) are capable of interacting with the rest pollutants in the environment, so they serve as the carriers and interact with organic pollutants to modulate their toxicity, thus resulting in unpredictable ecological risks. PS-NPs and TDCIPP were used expose from 2 h post-fertilization (hpf)
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Blood and tissue levels of persistent organic pollutants and genetic susceptibility in patients with breast cancer Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-04-06 İlgen Onat, Rasih Kocagöz, Merve Demirbügen Öz, Levent Yeniay, Yiğit Özer Tiftikçioğlu, Osman Zekioğlu, Gürdeniz Serin, Murat Özdemir, Ersin Gür, Halit Sinan Süzen, Hilmi Orhan
We investigated possible associations between the internal concentrations of POPs and correlations between blood and tumor tissue concentrations in patients who underwent surgery for breast cancer and breast reduction as controls. Genetic variations in CYP1A1, GSTP1, GSTM1, and GSTT1 and hOGG1 were evaluated to determine whether they represent risk factors for breast cancer. Certain POPs have been
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Impact of endocrine-active compounds on adrenal androgen production in pigs during neonatal period Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-04-06 Katarzyna Knapczyk-Stwora, Aleksandra Kozlowska, Damian Jastrzabek, Malgorzata Grzesiak, Maria Slomczynska, Marek Koziorowski
This study investigated the impact of neonatal exposure to endocrine-active compounds (EACs): flutamide (antiandrogen), 4--octylphenol (an estrogenic compound), and methoxychlor (an organochlorine insecticide exhibiting estrogenic, antiestrogenic and antiandrogenic activities) on androgen production within porcine adrenal glands. The expression of genes related to androgen synthesis and the level of
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Growth and physiological responses of submerged macrophytes to linear alkylbenzene sulfonate (LAS) Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-04-05 Cui-Min Han, Wen-Hua You
The potential toxic effects of linear alkylbenzene sulfonate (LAS), widely used in commercial detergents and cleaners, on submerged macrophytes remain unclear. We conducted a two-week exposure experiment to investigate LAS toxicity on five submerged macrophytes (four native and one exotic), focusing on their growth and physiological responses. The results showed that lower concentrations of LAS (<
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Surviving in a multistressor world: Gene expression changes in earthworms exposed to heat, desiccation, and chemicals Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-04-01 Natasha Tilikj, Mercedes de la Fuente, Ana Belén Muñiz González, José-Luis Martínez-Guitarte, Marta Novo
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Investigating the toxic mechanism of iron oxide nanoparticles-induced oxidative stress in tadpole (Duttaphrynus melanostictus): A combined biochemical and molecular study Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-03-28 Meesala Krishna Murthy, Pratima Khandayataray, Chandra Sekhar Mohanty, Rojalin Pattanayak
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Biological responses in Danio rerio by the disinfectant SDBS in SARS-CoV-2 pandemic Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-03-28 Beatriz Sousa, Inês Domingues, Bruno Nunes
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Concentration of trace elements in blood of Polish patients with prostate cancer Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-03-28 Joanna Maria Drozdz-Afelt, Beata Koim-Puchowska, Piotr Kaminski
The goal of the study was to analyse the concentrations of chemical elements (Fe, Ni, As, Cd, Pb, Hg, Cr, Zn) which are important for the determination of environmental toxins (e.g. resulting from smoking, exposure to harmful agents at work) in Polish patients with prostate cancer. The study covered 66 patients with diagnosed prostate cancer and 64 healthy volunteers over 50 years old. The analysis
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Chronic Aroclor 1260 exposure alters the mouse liver proteome, selenoproteins, and metals in steatotic liver disease Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-03-27 Kellianne M. Piell, Belinda J. Petri, Jason Xu, Lu Cai, Shesh N. Rai, Ming Li, Daniel W. Wilkey, Michael L. Merchant, Matthew C. Cave, Carolyn M. Klinge
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Glyphosate and aminomethylphosphonic acid metabolite (AMPA) modulate the phenotype of murine melanoma B16-F1 cells Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-03-26 Yvanna Carla de Souza Salgado Kiefer, Marianna Boia Ferreira, Jessica Zablocki da Luz, Francisco Filipak Neto, Ciro Alberto de Oliveira Ribeiro
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Exposure to the antineoplastic ifosfamide alters molecular pathways related to cardiovascular function, increases heart rate, and induces hyperactivity in zebrafish (Danio rerio) Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-03-23 Cole D. English, Kira J. Kazi, Isaac Konig, Emma Ivantsova, Christopher L. Souders II, Christopher J. Martyniuk
Ifosfamide is an alkylating antineoplastic drug used in chemotherapy, but it is also detected in wastewater. Here, the objectives were to (1) determine teratogenic, cardiotoxic, and mitochondrial toxicity potential of ifosfamide exposure; (2) elucidate mechanisms of toxicity; (3) characterize exposure effects on larval behavior. Survival rate, hatch rate, and morphological deformity incidence were
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Polystyrene microplastics with absorbed nonylphenol induce intestinal dysfunction in human Caco-2 cells Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-03-23 Fangfang Ding, Huimei Wang, Yingzhi Li, Xueping Leng, Jiaming Gao, Danfei Huang
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Transcriptional and phenotypical alterations associated with a gradual benzo[a]pyrene-induced transition of human bronchial epithelial cells into mesenchymal-like cells Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-03-22 Martina Hýžďalová, Jiřina Procházková, Nicol Straková, Kateřina Pěnčíková, Simona Strapáčová, Jana Slováčková, Simona Kajabová, Helena Líbalová, Jan Topinka, Markéta Kabátková, Jan Vondráček, Steen Mollerup, Miroslav Machala
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Biotoxicity responses of zebrafish in environmentally relevant concentration of di (2-ethylhexyl) phthalate Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-03-21 Xianxu Li, Shichang Hu, Nan Jiang, Xiangfeng Yao, Can Wang, Qian Wang, Zhongkang Yang, Jun Wang
As an emerging environmental contaminant, di (2-ethylhexyl) phthalate (DEHP) is widely present in the aquatic environment, however, the effects and underlying mechanisms of DEHP on the aquatic organisms are poorly understood. This study systematically investigated the ecotoxicity induced by chronic exposure to environmental relevant concentrations of DEHP (0.03 mg/L, 0.1 mg/L, and 0.3 mg/L) on zebrafish
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Anabolic steroids induced changes at the level of protein expression: Effects of prolonged administration of testosterone and nandrolone to pigs Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-03-21 Jan Gebauer, Nikola Hodkovicova, Kristina Tosnerova, Kristyna Skoupa, Andrej Batik, Iva Bartejsova, Michaela Charvatova, Lenka Leva, Rea Jarosova, Zbysek Sladek, Martin Faldyna, Kamil Stastny
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Beauvericin and enniatin B mycotoxins alter aquatic ecosystems: Effects on green algae Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-03-19 Ana Juan-García, Cristina Juan, Sami Taipale, Eeva-Riikka Vehniäinen
Myxotoxins can contaminate algal-based products and arrive to the food chain to consumers producing chronic toxicity effects. Here, we studied phytotoxicity of mycotoxins, beauvericin (BEA) and ennaitin B (ENN B) in four phytoplankton strains: , , and , which are all green algae. It was tested the capacity of clearing the media of BEA and ENN B at different concentrations by comparing nominal and measured
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Plants buffer some of the effects of a pair of cadmium-exposed zebrafish on the un-exposed majority Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-03-18 Delia S. Shelton, Piyumika S. Suriyampola, Zoe M. Dinges, Stephen P. Glaholt, Joseph R. Shaw, Emília P. Martins
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The ABCG2 protein in vitro transports the xenobiotic thiabendazole and increases the appearance of its residues in milk Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-03-16 Laura Álvarez–Fernández, Esther Blanco–Paniagua, Alicia Millán–García, Miriam Velasco-Díez, Ana I. Álvarez, Gracia Merino
Thiabendazole (TBZ) is a broad–spectrum anthelmintic and fungicide used in humans, animals, and agricultural commodities. TBZ residues are present in crops and animal products, including milk, posing a risk to food safety and public health. ABCG2 is a membrane transporter which affects bioavailability and milk secretion of xenobiotics. Therefore, the aim of this work was to characterize the role of
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Is photoelectrocatalysis an efficient process to degrade endocrine disruptors chemicals? Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-03-16 M. Cifre-Herrando, G. Roselló-Márquez, J. García-Antón
Endocrine disruptors chemicals (EDCs) pose significant health risks, including cancer, behavioral disorders, and infertility. In this study, we employed the photoelectrocatalysis (PEC) technique with optimized tungsten oxide (WO) nanostructures as a photoanode to degrade three diverse EDCs: methiocarb, dimethyl phthalate, and 4-tert-butylphenol. PEC degradation tests were carried out for individual
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In vivo assessment of the toxic impact of exposure to magnetic iron oxide nanoparticles (IONPs) using Drosophila melanogaster Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-03-16 Merve Güneş, Kemal Aktaş, Burçin Yalçın, Ayşen Yağmur Burgazlı, Meltem Asilturk, Ayca Erdem Ünşar, Bülent Kaya
Iron oxide nanoparticles (IONPs) have useful properties, such as strong magnetism and compatibility with living organisms which is preferable for medical applications such as drug delivery and imaging. However, increasing use of these materials, especially in medicine, has raised concerns regarding potential risks to human health. In this study, IONPs were coated with silicon dioxide (SiO), citric
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Role of prolactin in the protective effect of amisulpride against 1,2-Diacetylbenzene’s neurotoxicity Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-03-15 Ngoc Minh-Hong Hoang, Hai Duc Nguyen, Wonhee Jo, Min-Sun Kim
Exposure to organic solvents is associated with various health problems, including neurodegenerative diseases. Among these solvents, 1,2-diethylbenzene is notable for its ability to produce a toxic metabolite, 1,2-Diacetylbenzene (DAB), which can cause memory impairment. Prolactin (PRL) is theorized to protect the central nervous system. Certain antipsychotic drugs, known for increasing PRL secretion
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AuNPs with Cynara scolymus leaf extracts rescue arsenic-induced neurobehavioral deficits and hippocampal tissue toxicity in Balb/c mice through D1R and D2R activation Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-03-15 Betul Cicek, Ahmet Hacimuftuoglu, Yesim Yeni, Mehmet Kuzucu, Sidika Genc, Ahmet Cetin, Emre Yavuz, Betul Danısman, Akin Levent, Kemal Volkan Ozdokur, Mecit Kantarcı, Anca Oana Docea, Vasileios Siokas, Konstantinos Tsarouhas, Michael D. Coleman, Aristidis Tsatsakis, Ali Taghizadehghalehjoughi
The present study was designed to evaluate whether AuNPs (gold nanoparticles) synthesized with the (CS) leaf exert protective and/or alleviative effects on arsenic (As)-induced hippocampal neurotoxicity in mice. Neurotoxicity in mice was developed by orally treating 10 mg/kg/day sodium arsenite (NaAsO) for 21 days. 10 µg/g AuNPs, 1.6 g/kg CS, and 10 µg/g CS-AuNPs were administered orally simultaneously
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Fine particulate matter PM2.5 and its constituent, hexavalent chromium induce acute cytotoxicity in human airway epithelial cells via inflammasome-mediated pyroptosis Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-03-15 Aekkacha Moonwiriyakit, Sasiwimol Dinsuwannakol, Jenjira Sontikun, Kanokphorn Timpratueang, Chatchai Muanprasat, Phisit Khemawoot
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A meta-analysis of potential biomarkers associated with microplastic ingestion in marine fish Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-03-13 Montserrat Compa, Xavier Capó, Carme Alomar, Salud Deudero, Antoni Sureda
Over the past decade, global reports have shown a rise in the harmful effects of microplastics (MPs) on marine fish. This study analysed marine species' biochemical biomarker responses to microplastic exposure, finding that MPs can induce oxidative stress in marine fish through meta-regression results. Overall, exposure to MPs resulted in the activation of antioxidant defence mechanisms, such as superoxide
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Physicochemical properties of 26 carbon nanotubes as predictors for pulmonary inflammation and acute phase response in mice following intratracheal lung exposure Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-03-13 Pernille Høgh Danielsen, Sarah Søs Poulsen, Kristina Bram Knudsen, Per Axel Clausen, Keld Alstrup Jensen, Håkan Wallin, Ulla Vogel
Carbon nanotubes (CNTs) vary in physicochemical properties which makes risk assessment challenging. Mice were pulmonary exposed to 26 well-characterized CNTs using the same experimental design and followed for one day, 28 days or 3 months. This resulted in a unique dataset, which was used to identify physicochemical predictors of pulmonary inflammation and systemic acute phase response. MWCNT diameter
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Intravenous hypertonic fluids as a source of human microplastic exposure Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-03-05 Uğur Çağlayan, Sedat Gündoğdu, Tiffany M. Ramos, Kristian Syberg
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Cardiovascular disrupting effects of bisphenols, phthalates, and parabens related to endothelial dysfunction: Review of toxicological and pharmacological mechanisms Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-28 Cristina Lemini, Patricia Silveyra, Mariana Segovia-Mendoza
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Effect of beta-cypermethrin on the reproductive capacity of female mice in advanced age Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-28 Qian-Feng Qiao, Li-Qing Wang, De-E. Yu, Na Li, Qiong-Jun Xu, Yong-Jiang Zhou
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Decreased immune response in undernourished rats after air pollution exposure Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-24 Melisa Lidia Kurtz, Nadia Soledad Orona, Christian Lezón, Verónica Cecilia Defosse, Francisco Astort, Guillermo Alberto Maglione, Patricia Mónica Boyer, Deborah Ruth Tasat
Children are highly vulnerable subpopulation to malnutrition and air pollution. We investigate, in a rat nutritional growth retardation (NGR) model, the impact of Residual Oil Fly Ash (ROFA) on the lung immune response using and methods. : Alveolar macrophages (AM) were isolated from Control (C) and NGR animals, cultured and treated with ROFA (1–100 µg/ml) for 24 h. : C and NGR rats were intranasally
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Chronic arsenic exposure suppresses proteasomal and autophagic protein degradation Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-23 Isabell I. Augenstein, Alexandra N. Nail, Ana P. Ferragut Cardoso, J. Christopher States, Mayukh Banerjee
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Protection against β-N-methylamino-l-alanineꟷinduced vesicular monoamine transporter 2 inhibition by hydroxyl-containing proteinogenic amino acids Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-23 Rianita van Onselen, Chanté Kennedy, Tim G. Downing
β--methylamino--alanine (BMAA) has been shown to inhibit vesicular monoamine transporter 2 (VMAT2), thereby preventing the uptake of monoaminergic neurotransmitters into platelet dense granules and synaptic vesicles. The inhibition is hypothesized to be through direct association of BMAA with hydroxyl groupꟷcontaining amino acid residues in VMAT2. This study evaluated whether BMAA-induced inhibition
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Short-term effects of sodium arsenite (AsIII) and sodium arsenate (AsV) on carbohydrate metabolism in the perfused rat liver Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-23 Nairana Mithieli de Queiroz Eskuarek Melo, Jurandir Fernando Comar, Anacharis Babeto de Sá-Nakanishi, Rosane Marina Peralta, Lívia Bracht, Adelar Bracht
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Lead induced genotoxicity and hepatotoxicity in zebrafish (Danio rerio) at environmentally relevant concentration: Nrf2-Keap1 regulated stress response and expression of biomarker genes Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-22 Koushik Kumar Dey, Sreejata Kamila, Tanmoy Das, Ansuman Chattopadhyay
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Metal bioaccumulation and histological alterations in Oreochromis andersonii at Itezhi-tezhi Dam downstream of a mining area in the Central Province of Zambia Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-19 Chris Sihoka, Ina Wagenaar, Cobus van Dyk
The Itezhi-tezhi Dam on the Kafue River in Zambia is a major capture fishery. However, the upstream reaches of the Kafue River receive effluents from copper mines. It was unclear whether fish health in the dam is adversely affected due to the mining effluents. We investigated the health status of fish in Itezhi-tezh Dam using a histology-based fish health assessment protocol with as a bioindicator
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E-cigarettes exacerbate allergic inflammation via cytokine induction and MUC5AC/5B expression in a murine asthma model Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-19 Young-Ha Lee, Hyung Gyun Na, Yoon Seok Choi, Chang Hoon Bae, Si-Youn Song, Yong-Dae Kim
The effects of electronic cigarettes (e-cigarettes) vapor on inflammation and mucin secretion on asthmatics remain insufficiently explored. This study investigated the effects of e-cigarette vapor on allergic inflammation, cytokine production, and MUC5AC/5B expression in murine asthma model. Airway hyperresponsiveness was significantly higher in the e-cigarette-exposed ovalbumin (OVA) sensitization
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Genotoxicity responses of single and mixed exposure to heavy metals (cadmium, silver, and copper) as environmental pollutants in Drosophila melanogaster Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-16 Eşref Demir, Fatma Turna Demir
Heavy metals are now persistently present in living things' environments, in addition to their potential toxicity. Therefore, the aim of this study was to utilize . to determine the biological effects induced by different heavy metals including cadmium chloride (CdCl), copper (II) sulfate pentahydrate (CuSO 4.5 HO), and silver nitrate (AgNO). experiments were conducted utilizing three low and environmentally
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Impact of DEHP exposure on female reproductive health: Insights into uterine effects Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-16 Alejandra Martínez-Ibarra, Marco Cerbón, Luis Daniel Martínez-Razo, Miguel Morales-Pacheco, Iván Torre-Villalvazo, Simón Kawa, Mauricio Rodríguez-Dorantes
Several endocrine disrupting compounds released from plastics, including polyfluoroalkyl substances, bisphenols, flame retardants, phthalates and others, are of great concern to human health due to their high toxicity. This review discusses the effects of di-(2-ethylhexyl) phthalate (DEHP), the most common member of the phthalate family, on female reproduction. and studies link DEHP exposure to impaired
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PM2.5 induces cardiac defects via AHR-SIRT1-PGC-1α mediated mitochondrial damage Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-15 Jin Chen, Mingxuan Zhang, Stanley Aniagu, Yan Jiang, Tao Chen
Recent evidence indicates that PM poses a risk for congenital heart diseases but the mechanisms remain unclear. We hypothesized that AHR activated by PM might cause mitochondrial damage via PGC-1α dysregulation, leading to heart defects. We initially discovered that the PGC-1α activator ZLN005 counteracted cardiac defects in zebrafish larvae exposed to EOM (extractable organic matter) from PM. Moreover
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Butyl Benzyl Phthalate (BBP) disrupts neuromast development in embryonic zebrafish Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-15 Evelyn Paquette, John Paul Giacalone, Michael Fumo, Nicole M. Roy
Butyl benzyl phthalate (BBP) is found in common household and industrial products world-wide. Phthalates are not covalently bound to plastics and continuously leach into the soil, sediment and aquatic environments. The lateral line system of fish is a mechanosensory system composed of neuromasts essential for survival behaviors including rheotaxis, schooling and predator avoidance. Here, we investigated
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Histological Evidence of Hypothyroidism in Mice Chronically Exposed to Conventional Farming (Revised) Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-14 Nádia Coelho, Ricardo Camarinho, Patrícia Garcia, Armindo S Rodrigues
Worldwide, disorders of the thyroid gland are a growing concern; such can be caused by exposure to contaminants, including agrochemicals used in conventional agriculture, which act as endocrine disruptors. The purpose of this study is to evaluate whether or not exposure to an environment with conventional agriculture leads to thyroid disruption. were used as bioindicator species, captured in two sites:
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Depletion kinetics of semicarbazide in giant river prawn (Macrobrachium rosenbergii) following nitrofurazone oral administration and its occurrence in an aquaculture farm Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-13 Putsucha Phansawat, Niti Chuchird, Arunothai Keetanon, Natnicha Chongprachavat, Phongchate Pichitkul, Natthapong Paankhao, Suwinai Paankhao, Lalitphan Kitsanayanyong, Puttharat Baoprasertkul, Tirawat Rairat
Semicarbazide (SEM), a marker residue used to monitor the use of prohibited drug nitrofurazone (NFZ), is commonly found in wild crustaceans, implying the natural origin. However, the difference between endogenous and exogenous SEM has rarely been investigated. So, tissue-bound SEM was determined in samples collected from giant river prawns cultured in an aquaculture farm and in samples from an experiment