Cardiovascular diseases (CVDs) are the leading cause of death worldwide. CVDs are promoted by the accumulation of lipids and immune cells in the endothelial space resulting in endothelial dysfunction. Endothelial cells are important components of the vascular endothelium, that regulate the vascular flow. The imbalance in the production of vasoactive substances results in the loss of vascular homeostasis, leading the endothelial dysfunction. Thus, endothelial dysfunction plays an essential role in the development of atherosclerosis and can be triggered by different cardiovascular risk factors. On the other hand, the 17β-estradiol (E2) hormone has been related to the regulation of vascular tone through different mechanisms. Several compounds can elicit estrogenic actions similar to those of E2. For these reasons, they have been called endocrine-disrupting compounds (EDCs). This review aims to provide up-to-date information about how different EDCs affect endothelial function and their mechanistic roles in the context of CVDs.

中文翻译：

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双酚、邻苯二甲酸盐和对羟基苯甲酸酯与内皮功能障碍相关的心血管破坏作用：毒理学和药理学机制的回顾

心血管疾病（CVD）是全世界死亡的主要原因。内皮空间内脂质和免疫细胞的积累导致内皮功能障碍，从而促进心血管疾病。内皮细胞是血管内皮的重要组成部分，调节血管血流。血管活性物质产生的不平衡导致血管稳态丧失，导致内皮功能障碍。因此，内皮功能障碍在动脉粥样硬化的发展中起着至关重要的作用，并且可以由不同的心血管危险因素触发。另一方面，17β-雌二醇（E2）激素通过不同的机制与血管张力的调节有关。有几种化合物可以引发与 E2 类似的雌激素作用。由于这些原因，它们被称为内分泌干扰化合物（EDC）。本综述旨在提供有关不同 EDC 如何影响内皮功能及其在 CVD 中的机制作用的最新信息。