Carbon nanotubes (CNTs) vary in physicochemical properties which makes risk assessment challenging. Mice were pulmonary exposed to 26 well-characterized CNTs using the same experimental design and followed for one day, 28 days or 3 months. This resulted in a unique dataset, which was used to identify physicochemical predictors of pulmonary inflammation and systemic acute phase response. MWCNT diameter and SWCNT specific surface area were predictive of lower and higher neutrophil influx, respectively. Manganese and iron were shown to be predictive of higher neutrophil influx at day 1 post-exposure, whereas nickel content interestingly was predictive of lower neutrophil influx at all three time points and of lowered acute phase response at day 1 and 3 months post-exposure. It was not possible to separate effects of properties such as specific surface area and length in the multiple regression analyses due to co-variation.

中文翻译：

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26 碳纳米管的物理化学特性作为气管内肺暴露后小鼠肺部炎症和急性期反应的预测因子

碳纳米管 (CNT) 的物理化学性质各不相同，这使得风险评估具有挑战性。使用相同的实验设计，将小鼠肺部暴露于 26 个充分表征的碳纳米管，并随访 1 天、28 天或 3 个月。这产生了一个独特的数据集，用于识别肺部炎症和全身急性期反应的理化预测因子。多壁碳纳米管直径和单壁碳纳米管比表面积分别预示着中性粒细胞流入量的减少和增加。锰和铁被证明可以预测暴露后第 1 天较高的中性粒细胞流入，而有趣的是，镍含量可以预测所有三个时间点较低的中性粒细胞流入以及暴露后第 1 天和第 3 个月较低的急性期反应。由于共变，在多元回归分析中不可能分离比表面积和长度等特性的影响。