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Concentration of trace elements in blood of Polish patients with prostate cancer
Environmental Toxicology and Pharmacology ( IF 4.3 ) Pub Date : 2024-03-28 , DOI: 10.1016/j.etap.2024.104425
Joanna Maria Drozdz-Afelt , Beata Koim-Puchowska , Piotr Kaminski

The goal of the study was to analyse the concentrations of chemical elements (Fe, Ni, As, Cd, Pb, Hg, Cr, Zn) which are important for the determination of environmental toxins (e.g. resulting from smoking, exposure to harmful agents at work) in Polish patients with prostate cancer. The study covered 66 patients with diagnosed prostate cancer and 64 healthy volunteers over 50 years old. The analysis of the concentrations of selected chemical elements in whole blood was performed using inductively coupled plasma mass spectrometry (ICP-MS). In their blood, the patients with cancer had a significantly higher concentration of only one of the examined elements: arsenic. Additionally, the study group had lower concentrations of chromium, zinc, but also cadmium and lead, which are commonly regarded as carcinogenic. Taking into consideration the control group of healthy subjects of this study, we can assume that the subjects with prostate cancer were exposed to higher levels of arsenic, and that exposure to this element may be associated with an increased risk of cancer.

中文翻译:

波兰前列腺癌患者血液中微量元素浓度

该研究的目的是分析化学元素(铁、镍、砷、镉、铅、汞、铬、锌)的浓度,这些元素对于确定环境毒素(例如吸烟、暴露于有害物质所产生的毒素)非常重要。工作)在波兰前列腺癌患者中。该研究涵盖了 66 名确诊前列腺癌的患者和 64 名 50 岁以上的健康志愿者。使用电感耦合等离子体质谱 (ICP-MS) 对全血中选定化学元素的浓度进行分析。在癌症患者的血液中,只有一种被检测元素的浓度显着升高:砷。此外,研究组的铬、锌、镉和铅浓度较低,而镉和铅通常被认为是致癌物质。考虑到本研究的健康受试者对照组,我们可以假设患有前列腺癌的受试者暴露于较高水平的砷,并且暴露于这种元素可能与癌症风险增加有关。
更新日期:2024-03-28
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