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A human omentum-specific mesothelial-like stromal population inhibits adipogenesis through IGFBP2 secretion Cell Metab. (IF 29.0) Pub Date : 2024-05-09 Radiana Ferrero, Pernille Yde Rainer, Marie Rumpler, Julie Russeil, Magda Zachara, Joern Pezoldt, Guido van Mierlo, Vincent Gardeux, Wouter Saelens, Daniel Alpern, Lucie Favre, Nathalie Vionnet, Styliani Mantziari, Tobias Zingg, Nelly Pitteloud, Michel Suter, Maurice Matter, Kai-Uwe Schlaudraff, Carles Canto, Bart Deplancke
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Diabetic retinopathy is a ceramidopathy reversible by anti-ceramide immunotherapy Cell Metab. (IF 29.0) Pub Date : 2024-05-07 Tim F. Dorweiler, Arjun Singh, Aditya Ganju, Todd A. Lydic, Louis C. Glazer, Richard N. Kolesnick, Julia V. Busik
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A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1 Cell Metab. (IF 29.0) Pub Date : 2024-05-07 Suchira Gallage, Adnan Ali, Jose Efren Barragan Avila, Nogayhan Seymen, Pierluigi Ramadori, Vera Joerke, Laimdota Zizmare, David Aicher, Indresh K. Gopalsamy, Winnie Fong, Jan Kosla, Enrico Focaccia, Xin Li, Suhail Yousuf, Tjeerd Sijmonsma, Mohammad Rahbari, Katharina S. Kommoss, Adrian Billeter, Sandra Prokosch, Ulrike Rothermel, Mathias Heikenwalder
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Gut microbial alterations in arginine metabolism determine bone mechanical adaptation Cell Metab. (IF 29.0) Pub Date : 2024-05-07 Dan Wang, Jing Cai, Qilin Pei, Zedong Yan, Feng Zhu, Zhe Zhao, Ruobing Liu, Xiangyang Guo, Tao Sun, Juan Liu, Yulan Tian, Hongbo Liu, Xi Shao, Jinghui Huang, Xiaoxia Hao, Qi Chang, Zhuojing Luo, Da Jing
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Obesity disrupts the pituitary-hepatic UPR communication leading to NAFLD progression Cell Metab. (IF 29.0) Pub Date : 2024-05-07 Qingwen Qian, Mark Li, Zeyuan Zhang, Shannon W. Davis, Kamal Rahmouni, Andrew W. Norris, Huojun Cao, Wen-Xing Ding, Gökhan S. Hotamisligil, Ling Yang
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Targeting metabolic circuitry to supercharge CD8+ T cell antitumor responses Cell Metab. (IF 29.0) Pub Date : 2024-05-07 Qiang Cai, Yihao Tian, Quazi T.H. Shubhra
Tumors compromise T cell functionality through various mechanisms, including the induction of a nutrient-scarce microenvironment, leading to lipid accumulation and metabolic reprogramming. Hunt et al. elucidate acetyl-CoA carboxylase’s crucial role in regulating lipid metabolism in CD8+ T cells, uncovering a novel metabolic strategy to potentiate antitumor immune responses.
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Dysregulated BH4 metabolism facilitates immunosuppression in pancreatic cancer Cell Metab. (IF 29.0) Pub Date : 2024-05-07 Shane J.F. Cronin
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive, malignant, and lethal cancers, displaying strong resistance to immunotherapy. In this issue of Cell Metabolism, a study by Liu et al. identifies tetrahydrobiopterin metabolic dysregulation as a key driver for the immunosuppressive PDAC environment in mouse and human.
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Understanding osteokine biology Cell Metab. (IF 29.0) Pub Date : 2024-05-07 Mone Zaidi, Samir Zaidi, Tony Yuen
Bone is an endocrine organ that participates in whole-body homeostasis. The biology of bone-derived osteokines, however, remains unclear. Liang et al. integrate experimental and computational methods to discover new osteokines, establish their cell of origin and target site, and study their role in aging and during mechanical stress.
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Branching out beyond canonical brown adipocyte function Cell Metab. (IF 29.0) Pub Date : 2024-05-07 Helaina Von Bank, Judith Simcox
Brown adipose tissue has long been functionally characterized as an organ that regulates thermogenesis, body weight set point, and glucose homeostasis. In the May 9, 2024, issue of Cell, Verkerke et al. discover a novel function for brown adipose tissue in processing branched-chain amino acids into antioxidant metabolites that enter the circulation and regulate insulin signaling in the liver.
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Hepatic selective insulin resistance at the intersection of insulin signaling and metabolic dysfunction-associated steatotic liver disease Cell Metab. (IF 29.0) Pub Date : 2024-05-07 Tao Bo, Ling Gao, Zhenyu Yao, Shanshan Shao, Xuemin Wang, Christopher G. Proud, Jiajun Zhao
Insulin resistance (IR) is a major pathogenic factor in the progression of MASLD. In the liver, insulin suppresses gluconeogenesis and enhances de novo lipogenesis (DNL). During IR, there is a defect in insulin-mediated suppression of gluconeogenesis, but an unrestrained increase in hepatic lipogenesis persists. The mechanism of increased hepatic steatosis in IR is unclear and remains controversial
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A novel protein CYTB-187AA encoded by the mitochondrial gene CYTB modulates mammalian early development Cell Metab. (IF 29.0) Pub Date : 2024-05-03 Zhijuan Hu, Liang Yang, Maolei Zhang, Haite Tang, Yile Huang, Yujie Su, Yingzhe Ding, Chong Li, Mengfei Wang, Yunhao Zhou, Qing Zhang, Liman Guo, Yue Wu, Qianqian Wang, Ning Liu, Haoran Kang, Yi Wu, Deyang Yao, Yukun Li, Zifeng Ruan, Xingguo Liu
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The mitochondrial multi-omic response to exercise training across rat tissues Cell Metab. (IF 29.0) Pub Date : 2024-05-02 David Amar, Nicole R. Gay, David Jimenez-Morales, Pierre M. Jean Beltran, Megan E. Ramaker, Archana Natarajan Raja, Bingqing Zhao, Yifei Sun, Shruti Marwaha, David A. Gaul, Steven G. Hershman, Alexis Ferrasse, Ashley Xia, Ian Lanza, Facundo M. Fernández, Stephen B. Montgomery, Andrea L. Hevener, Euan A. Ashley, Martin J. Walsh, Lauren M. Sparks, Jimmy Zhen
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Dietary intake and glutamine-serine metabolism control pathologic vascular stiffness Cell Metab. (IF 29.0) Pub Date : 2024-05-02 Nesrine S. Rachedi, Ying Tang, Yi-Yin Tai, Jingsi Zhao, Caroline Chauvet, Julien Grynblat, Kouamé Kan Firmin Akoumia, Leonard Estephan, Stéphanie Torrino, Chaima Sbai, Amel Ait-Mouffok, Joseph D. Latoche, Yassmin Al Aaraj, Frederic Brau, Sophie Abélanet, Stephan Clavel, Yingze Zhang, Christelle Guillermier, Naveen V.G. Kumar, Sina Tavakoli, Stephen Y. Chan
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Immunological regulation of skeletal muscle adaptation to exercise Cell Metab. (IF 29.0) Pub Date : 2024-04-25 P. Kent Langston, Diane Mathis
Exercise has long been acknowledged for its powerful disease-preventing, health-promoting effects. However, the cellular and molecular mechanisms responsible for the beneficial effects of exercise are not fully understood. Inflammation is a component of the stress response to exercise. Recent work has revealed that such inflammation is not merely a symptom of exertion; rather, it is a key regulator
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TM7SF3 controls TEAD1 splicing to prevent MASH-induced liver fibrosis Cell Metab. (IF 29.0) Pub Date : 2024-04-25 Roi Isaac, Gautam Bandyopadhyay, Theresa V. Rohm, Sion Kang, Jinyue Wang, Narayan Pokhrel, Sadatsugu Sakane, Rizaldy Zapata, Avraham M. Libster, Yaron Vinik, Asres Berhan, Tatiana Kisseleva, Zea Borok, Yehiel Zick, Francesca Telese, Nicholas J.G. Webster, Jerrold M. Olefsky
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New and emerging treatments for metabolic dysfunction-associated steatohepatitis Cell Metab. (IF 29.0) Pub Date : 2024-04-25 Monica A. Tincopa, Quentin M. Anstee, Rohit Loomba
No Abstract
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Exploratory physiological experiments are not clinical trials Cell Metab. (IF 29.0) Pub Date : 2024-04-25 Erik A. Richter, David E. James, John P. Kirwan, Juleen R. Zierath
No Abstract
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Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK Cell Metab. (IF 29.0) Pub Date : 2024-04-23 Yajuan Li, Daniel Munoz-Mayorga, Yuhang Nie, Ningxin Kang, Yuren Tao, Jessica Lagerwall, Carla Pernaci, Genevieve Curtin, Nicole G. Coufal, Jerome Mertens, Lingyan Shi, Xu Chen
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Loss of GPR75 protects against non-alcoholic fatty liver disease and body fat accumulation Cell Metab. (IF 29.0) Pub Date : 2024-04-22 Alasdair Leeson-Payne, Jean Iyinikkel, Cameron Malcolm, Brian Y.H. Lam, Nadine Sommer, Georgina K.C. Dowsett, Pablo B. Martinez de Morentin, Dawn Thompson, Alasdair Mackenzie, Raffaella Chianese, Katherine Kentistou, Eugene J. Gardner, John R.B. Perry, Felix Grassmann, John R. Speakman, Justin J. Rochford, Giles S.H. Yeo, Fiona Murray, Lora K. Heisler
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QDPR deficiency drives immune suppression in pancreatic cancer Cell Metab. (IF 29.0) Pub Date : 2024-04-19 Ji Liu, Xiaowei He, Shuang Deng, Sihan Zhao, Shaoping Zhang, Ziming Chen, Chunling Xue, Lingxing Zeng, Hongzhe Zhao, Yifan Zhou, Ruihong Bai, Zilan Xu, Shaoqiu Liu, Quanbo Zhou, Mei Li, Jialiang Zhang, Xudong Huang, Rufu Chen, Liqin Wang, Dongxin Lin, Jian Zheng
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The intersection of frailty and metabolism Cell Metab. (IF 29.0) Pub Date : 2024-04-12 Manish Mishra, Judy Wu, Alice E. Kane, Susan E. Howlett
On average, aging is associated with unfavorable changes in cellular metabolism, which are the processes involved in the storage and expenditure of energy. However, metabolic dysregulation may not occur to the same extent in all older individuals as people age at different rates. Those who are aging rapidly are at increased risk of adverse health outcomes and are said to be “frail.” Here, we explore
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New and emerging treatments for metabolic dysfunction-associated steatohepatitis Cell Metab. (IF 29.0) Pub Date : 2024-04-11 Monica A. Tincopa, Quentin M. Anstee, Rohit Loomba
Metabolic dysfunction-associated steatohepatitis (MASH) is a leading etiology of chronic liver disease worldwide, with increasing incidence and prevalence in the setting of the obesity epidemic. MASH is also a leading indication for liver transplantation, given its associated risk of progression to end-stage liver disease. A key challenge in managing MASH is the lack of approved pharmacotherapy. In
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ATF3 and CH25H regulate effector trogocytosis and anti-tumor activities of endogenous and immunotherapeutic cytotoxic T lymphocytes Cell Metab. (IF 29.0) Pub Date : 2024-04-11 Zhen Lu, Noreen McBrearty, Jinyun Chen, Vivek S. Tomar, Hongru Zhang, Gianluca De Rosa, Aiwen Tan, Aalim M. Weljie, Daniel P. Beiting, Zhen Miao, Subin S. George, Allison Berger, Gurpanna Saggu, J. Alan Diehl, Constantinos Koumenis, Serge Y. Fuchs
Abstract not available
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Single-cell senescence identification reveals senescence heterogeneity, trajectory, and modulators Cell Metab. (IF 29.0) Pub Date : 2024-04-10 Wanyu Tao, Zhengqing Yu, Jing-Dong J. Han
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Gut bacteria-driven homovanillic acid alleviates depression by modulating synaptic integrity Cell Metab. (IF 29.0) Pub Date : 2024-04-05 Mingliang Zhao, Zhenxing Ren, Aihua Zhao, Yajun Tang, Junliang Kuang, Mengci Li, Tianlu Chen, Shouli Wang, Jieyi Wang, Huiheng Zhang, Jijun Wang, Tianhong Zhang, Jiahui Zeng, Xiaohua Liu, Guoxiang Xie, Penghong Liu, Ning Sun, Tianhao Bao, Tongtong Nie, Jingchao Lin, Ping Liu, Yuanyi Zheng, Xiaojiao Zheng, Tiemin Liu, Wei Jia
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An integrated multi-omics analysis reveals osteokines involved in global regulation Cell Metab. (IF 29.0) Pub Date : 2024-04-03 Wenquan Liang, Tiantian Wei, Le Hu, Meijun Chen, Liping Tong, Wu Zhou, Xingwei Duan, Xiaoyang Zhao, Weijie Zhou, Qing Jiang, Guozhi Xiao, Weiguo Zou, Di Chen, Zhipeng Zou, Xiaochun Bai
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A clinical-stage Nrf2 activator suppresses osteoclast differentiation via the iron-ornithine axis Cell Metab. (IF 29.0) Pub Date : 2024-04-02 Yimin Dong, Honglei Kang, Renpeng Peng, Zheming Liu, Fuben Liao, Shi-an Hu, Weizhong Ding, Pengju Wang, Pengchao Yang, Meipeng Zhu, Sibo Wang, Minglong Wu, Dawei Ye, Xin Gan, Feng Li, Kehan Song
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Developing a national nutrition policy strategy to advance cardiometabolic health and health equity Cell Metab. (IF 29.0) Pub Date : 2024-04-02 Dariush Mozaffarian, Emily A. Callahan, Dan Glickman, Melissa Maitin-Shepard
Abstract not available
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Our extended microbiome: The human-relevant metabolites and biology of fermented foods Cell Metab. (IF 29.0) Pub Date : 2024-04-02 Elisa B. Caffrey, Justin L. Sonnenburg, Suzanne Devkota
One of the key modes of microbial metabolism occurring in the gut microbiome is fermentation. This energy-yielding process transforms common macromolecules like polysaccharides and amino acids into a wide variety of chemicals, many of which are relevant to microbe-microbe and microbe-host interactions. Analogous transformations occur during the production of fermented foods, resulting in an abundance
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Unlocking the power of postbiotics: A revolutionary approach to nutrition for humans and animals Cell Metab. (IF 29.0) Pub Date : 2024-04-02 Xinjie Zhao, Shuai Liu, Sumin Li, Wen Jiang, Jingjun Wang, Jianxin Xiao, Tianyu Chen, Jiaying Ma, Muhammad Zahoor Khan, Wei Wang, Mengmeng Li, Shengli Li, Zhijun Cao
Postbiotics, which comprise inanimate microorganisms or their constituents, have recently gained significant attention for their potential health benefits. Extensive research on postbiotics has uncovered many beneficial effects on hosts, including antioxidant activity, immunomodulatory effects, gut microbiota modulation, and enhancement of epithelial barrier function. Although these features resemble
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Cardiometabolic characteristics of people with metabolically healthy and unhealthy obesity Cell Metab. (IF 29.0) Pub Date : 2024-04-02 Max C. Petersen, Gordon I. Smith, Hector H. Palacios, Sarah S. Farabi, Mihoko Yoshino, Jun Yoshino, Kevin Cho, Victor G. Davila-Roman, Mahalakshmi Shankaran, Ruteja A. Barve, Jinsheng Yu, Jennifer H. Stern, Bruce W. Patterson, Marc K. Hellerstein, Gerald I. Shulman, Gary J. Patti, Samuel Klein
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Central inhibition of HDAC6 re-sensitizes leptin signaling during obesity to induce profound weight loss Cell Metab. (IF 29.0) Pub Date : 2024-04-02 Dongxian Guan, Yuqin Men, Alexander Bartlett, Mario Andrés Salazar Hernández, Jie Xu, Xinchi Yi, Hu-song Li, Dong Kong, Ralph Mazitschek, Umut Ozcan
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Futile cycles: Emerging utility from apparent futility Cell Metab. (IF 29.0) Pub Date : 2024-04-01 Anand Kumar Sharma, Radhika Khandelwal, Christian Wolfrum
Futile cycles are biological phenomena where two opposing biochemical reactions run simultaneously, resulting in a net energy loss without appreciable productivity. Such a state was presumed to be a biological aberration and thus deemed an energy-wasting “futile” cycle. However, multiple pieces of evidence suggest that biological utilities emerge from futile cycles. A few established functions of futile
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Transketolase promotes MAFLD by limiting inosine-induced mitochondrial activity Cell Metab. (IF 29.0) Pub Date : 2024-03-27 Lingfeng Tong, Zhangbing Chen, Yangyang Li, Xinxia Wang, Changjie Yang, Yakui Li, Yemin Zhu, Ying Lu, Qi Liu, Nannan Xu, Sijia Shao, Lifang Wu, Ping Zhang, Guangyu Wu, Xiaoyu Wu, Xiaosong Chen, Junwei Fang, Renbing Jia, Tianle Xu, Bin Li, Liang Zheng, Junling Liu, Xuemei Tong
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Tumor-secreted FGF21 acts as an immune suppressor by rewiring cholesterol metabolism of CD8+T cells Cell Metab. (IF 29.0) Pub Date : 2024-03-26 Cegui Hu, Wen Qiao, Xiang Li, Zhi-kun Ning, Jiang Liu, Sumiya Dalangood, Hanjun Li, Xiang Yu, Zhen Zong, Zhenke Wen, Jun Gui
Abstract not available
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The effects of pregnancy, its progression, and its cessation on human (maternal) biological aging Cell Metab. (IF 29.0) Pub Date : 2024-03-22 Hung Pham, Tara Thompson-Felix, Darina Czamara, Jerod M. Rasmussen, Adam Lombroso, Sonja Entringer, Elisabeth B. Binder, Pathik D. Wadhwa, Claudia Buss, Kieran J. O’Donnell
Abstract not available
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Cytosolic pH is a direct nexus in linking environmental cues with insulin processing and secretion in pancreatic β cells Cell Metab. (IF 29.0) Pub Date : 2024-03-20 Yujiang Fang, Hexi Feng, Bowen Zhang, Shuwei Zhang, Yanjie Zhou, Pengcheng Hao, Zhongshu Zhou, Shanshan Zhou, Nan Li, Yi Hui, Lin Ma, Jie Xiong, Jinjin Wu, Ling Liu, Xiaoqing Zhang
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Transcriptomic, epigenomic, and spatial metabolomic cell profiling redefines regional human kidney anatomy Cell Metab. (IF 29.0) Pub Date : 2024-03-20 Haikuo Li, Dian Li, Nicolas Ledru, Qiao Xuanyuan, Haojia Wu, Amish Asthana, Lori N. Byers, Stefan G. Tullius, Giuseppe Orlando, Sushrut S. Waikar, Benjamin D. Humphreys
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Physiologic disruption and metabolic reprogramming in infection and sepsis Cell Metab. (IF 29.0) Pub Date : 2024-03-20 Katharina Willmann, Luis F. Moita
Effective responses against severe systemic infection require coordination between two complementary defense strategies that minimize the negative impact of infection on the host: resistance, aimed at pathogen elimination, and disease tolerance, which limits tissue damage and preserves organ function. Resistance and disease tolerance mostly rely on divergent metabolic programs that may not operate
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Acetyl-CoA carboxylase obstructs CD8+ T cell lipid utilization in the tumor microenvironment Cell Metab. (IF 29.0) Pub Date : 2024-03-14 Elizabeth G. Hunt, Katie E. Hurst, Brian P. Riesenberg, Andrew S. Kennedy, Evelyn J. Gandy, Alex M. Andrews, Coral del Mar Alicea Pauneto, Lauren E. Ball, Emily D. Wallace, Peng Gao, Jeremy Meier, John J. Serody, Michael F. Coleman, Jessica E. Thaxton
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Impaired skeletal muscle regeneration in diabetes: From cellular and molecular mechanisms to novel treatments Cell Metab. (IF 29.0) Pub Date : 2024-03-14 Ever Espino-Gonzalez, Emilie Dalbram, Rémi Mounier, Julien Gondin, Jean Farup, Niels Jessen, Jonas T. Treebak
Diabetes represents a major public health concern with a considerable impact on human life and healthcare expenditures. It is now well established that diabetes is characterized by a severe skeletal muscle pathology that limits functional capacity and quality of life. Increasing evidence indicates that diabetes is also one of the most prevalent disorders characterized by impaired skeletal muscle regeneration
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Judith Campisi (1948–2024) Cell Metab. (IF 29.0) Pub Date : 2024-03-14 Eric Verdin
Abstract not available
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Fndc5 is translated from an upstream ATG start codon and cleaved to produce irisin myokine precursor protein in humans and mice Cell Metab. (IF 29.0) Pub Date : 2024-03-11 Nathan H. Witmer, Connor R. Linzer, Ryan L. Boudreau
Abstract not available
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Aging-induced tRNAGlu-derived fragment impairs glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization Cell Metab. (IF 29.0) Pub Date : 2024-03-07 Dingfeng Li, Xinyi Gao, Xiaolin Ma, Ming Wang, Chuandong Cheng, Tian Xue, Feng Gao, Yong Shen, Juan Zhang, Qiang Liu
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Age-related ciliopathy: Obesogenic shortening of melanocortin-4 receptor-bearing neuronal primary cilia Cell Metab. (IF 29.0) Pub Date : 2024-03-06 Manami Oya, Yoshiki Miyasaka, Yoshiko Nakamura, Miyako Tanaka, Takayoshi Suganami, Tomoji Mashimo, Kazuhiro Nakamura
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Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability Cell Metab. (IF 29.0) Pub Date : 2024-03-05 Stanislaw Deja, Justin A. Fletcher, Chai-Wan Kim, Blanka Kucejova, Xiaorong Fu, Monika Mizerska, Morgan Villegas, Natalia Pudelko-Malik, Nicholas Browder, Melissa Inigo-Vollmer, Cameron J. Menezes, Prashant Mishra, Eric D. Berglund, Jeffrey D. Browning, John P. Thyfault, Jamey D. Young, Jay D. Horton, Shawn C. Burgess
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Supercharging cancer-fighting T cells with lithium carbonate Cell Metab. (IF 29.0) Pub Date : 2024-03-05 Yue Xu, Kaili Ma, Lianjun Zhang, Guideng Li
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Itaconate boosts malaria via induction of PD-L1 Cell Metab. (IF 29.0) Pub Date : 2024-03-05 Yukun Min, Luke A.J. O’Neill
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Carnosine facilitates lysosomal release of inhibitors of T cell surveillance Cell Metab. (IF 29.0) Pub Date : 2024-03-05 Pawel Swietach, Marja Jäättelä, Shari Pillon-Thomas, Ebbe Boedtkjer
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UCP1 and CKB are parallel players in BAT Cell Metab. (IF 29.0) Pub Date : 2024-03-05 Meng Dong, Ziyu Cheng, Wanzhu Jin
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Transforming the cardiometabolic disease landscape: Multimodal AI-powered approaches in prevention and management Cell Metab. (IF 29.0) Pub Date : 2024-02-29 Evan D. Muse, Eric J. Topol
The rise of artificial intelligence (AI) has revolutionized various scientific fields, particularly in medicine, where it has enabled the modeling of complex relationships from massive datasets. Initially, AI algorithms focused on improved interpretation of diagnostic studies such as chest X-rays and electrocardiograms in addition to predicting patient outcomes and future disease onset. However, AI
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Gut microbial co-metabolite 2-methylbutyrylcarnitine exacerbates thrombosis via binding to and activating integrin α2β1 Cell Metab. (IF 29.0) Pub Date : 2024-02-23 Kan Huang, Zilun Li, Xi He, Jun Dai, Bingding Huang, Yongxia Shi, Dongxiao Fan, Zefeng Zhang, Yunchong Liu, Na Li, Zhongyu Zhang, Jiangyun Peng, Chenshu Liu, Renli Zeng, Zhipeng Cen, Tengyao Wang, Wenchao Yang, Meifeng Cen, Jingyu Li, Shuai Yuan, Lu Zhang, Dandan Hu, Shuxiang Huang, Pin Chen, Peilong Lai, Liyan Lin, Jielu Wen, Zhengde Zhao, Xiuyi Huang, Lining Yuan, Lifang Zhou, Haoliang Wu, Lihua
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IgG is an aging factor that drives adipose tissue fibrosis and metabolic decline Cell Metab. (IF 29.0) Pub Date : 2024-02-19 Lexiang Yu, Qianfen Wan, Qiongming Liu, Yong Fan, Qiuzhong Zhou, Alicja A. Skowronski, Summer Wang, Zhengping Shao, Chen-Yu Liao, Lei Ding, Brian K. Kennedy, Shan Zha, Jianwen Que, Charles A. LeDuc, Lei Sun, Liheng Wang, Li Qiang
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Methionine secreted by tumor-associated pericytes supports cancer stem cells in clear cell renal carcinoma Cell Metab. (IF 29.0) Pub Date : 2024-02-19 ChuanJie Zhang, ZunGuo Du, Yi Gao, Kiat Shenq Lim, WenJie Zhou, Hai Huang, HongChao He, Jun Xiao, DanFeng Xu, QingQuan Li
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Sphingolipid metabolism controls mammalian heart regeneration Cell Metab. (IF 29.0) Pub Date : 2024-02-16 Xiaoqian Ji, Zihao Chen, Qiyuan Wang, Bin Li, Yan Wei, Yun Li, Jianqing Lin, Weisheng Cheng, Yijie Guo, Shilin Wu, Longkun Mao, Yuzhou Xiang, Tian Lan, Shanshan Gu, Meng Wei, Joe Z. Zhang, Lan Jiang, Jia Wang, Jin Xu, Nan Cao
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SLC25A51 decouples the mitochondrial NAD+/NADH ratio to control proliferation of AML cells Cell Metab. (IF 29.0) Pub Date : 2024-02-14 Mu-Jie Lu, Jonathan Busquets, Valeria Impedovo, Crystal N. Wilson, Hsin-Ru Chan, Yu-Tai Chang, William Matsui, Stefano Tiziani, Xiaolu A. Cambronne
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Dietary elaidic acid boosts tumoral antigen presentation and cancer immunity via ACSL5 Cell Metab. (IF 29.0) Pub Date : 2024-02-12 Yongfeng Lai, Yuan Gao, Junhong Lin, Fangfang Liu, Liguo Yang, Jie Zhou, Ying Xue, Yan Li, Zhenzhen Chang, Jing Li, Tengfei Chao, Jing Chen, Xiang Cheng, Xianfu Gao, Xiong Li, Fujia Lu, Qian Chu, Weimin Wang
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DGAT2 inhibition blocks SREBP-1 cleavage and improves hepatic steatosis by increasing phosphatidylethanolamine in the ER Cell Metab. (IF 29.0) Pub Date : 2024-02-09 Shunxing Rong, Mingfeng Xia, Goncalo Vale, Simeng Wang, Chai-Wan Kim, Shili Li, Jeffrey G. McDonald, Arun Radhakrishnan, Jay D. Horton
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Interorgan rhythmicity as a feature of healthful metabolism Cell Metab. (IF 29.0) Pub Date : 2024-02-08 Joseph Bass
The finding that animals with circadian gene mutations exhibit diet-induced obesity and metabolic syndrome with hypoinsulinemia revealed a distinct role for the clock in the brain and peripheral tissues. Obesogenic diets disrupt rhythmic sleep/wake patterns, feeding behavior, and transcriptional networks, showing that metabolic signals reciprocally control the clock. Providing access to high-fat diet
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Region-specific transcriptomic responses to obesity and diabetes in macaque hypothalamus Cell Metab. (IF 29.0) Pub Date : 2024-02-06 Ying Lei, Xian Liang, Yunong Sun, Ting Yao, Hongyu Gong, Zhenhua Chen, Yuanqing Gao, Hui Wang, Ru Wang, Yunqi Huang, Tao Yang, Miao Yu, Longqi Liu, Chun-Xia Yi, Qing-Feng Wu, Xingxing Kong, Xun Xu, Shiping Liu, Zhi Zhang, Tiemin Liu
The hypothalamus plays a crucial role in the progression of obesity and diabetes; however, its structural complexity and cellular heterogeneity impede targeted treatments. Here, we profiled the single-cell and spatial transcriptome of the hypothalamus in obese and sporadic type 2 diabetic macaques, revealing primate-specific distributions of clusters and genes as well as spatial region, cell-type-