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An age-progressive platelet differentiation path from hematopoietic stem cells causes exacerbated thrombosis Cell (IF 64.5) Pub Date : 2024-05-14 Donna M. Poscablo, Atesh K. Worthington, Stephanie Smith-Berdan, Marcel G.E. Rommel, Bryce A. Manso, Reheman Adili, Lydia Mok, Roman E. Reggiardo, Taylor Cool, Raana Mogharrab, Jenna Myers, Steven Dahmen, Paloma Medina, Anna E. Beaudin, Scott W. Boyer, Michael Holinstat, Vanessa D. Jonsson, E. Camilla Forsberg
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The first two blastomeres contribute unequally to the human embryo Cell (IF 64.5) Pub Date : 2024-05-13 Sergi Junyent, Maciej Meglicki, Roman Vetter, Rachel Mandelbaum, Catherine King, Ekta M. Patel, Lisa Iwamoto-Stohl, Clare Reynell, Dong-Yuan Chen, Patrizia Rubino, Nabil Arrach, Richard J. Paulson, Dagmar Iber, Magdalena Zernicka-Goetz
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Osr2 functions as a biomechanical checkpoint to aggravate CD8+ T cell exhaustion in tumor Cell (IF 64.5) Pub Date : 2024-05-13 Jinjia Zhang, Junhong Li, Yongqiang Hou, Yao Lin, Hao Zhao, Yiran Shi, Kaiyun Chen, Cheng Nian, Jiayu Tang, Lei Pan, Yunzhi Xing, Huan Gao, Bingying Yang, Zengfang Song, Yao Cheng, Yue Liu, Min Sun, Yueyue Linghu, Jiaxin Li, Haitao Huang, Dawang Zhou
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Vertebrate centromeres in mitosis are functionally bipartite structures stabilized by cohesin Cell (IF 64.5) Pub Date : 2024-05-13 Carlos Sacristan, Kumiko Samejima, Lorena Andrade Ruiz, Moonmoon Deb, Maaike L.A. Lambers, Adam Buckle, Chris A. Brackley, Daniel Robertson, Tetsuya Hori, Shaun Webb, Robert Kiewisz, Tristan Bepler, Eloïse van Kwawegen, Patrik Risteski, Kruno Vukušić, Iva M. Tolić, Thomas Müller-Reichert, Tatsuo Fukagawa, Nick Gilbert, Davide Marenduzzo, Geert J.P.L. Kops
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Perivascular neurons instruct 3D vascular lattice formation via neurovascular contact Cell (IF 64.5) Pub Date : 2024-05-10 Kenichi Toma, Mengya Zhao, Shaobo Zhang, Fei Wang, Hannah K. Graham, Jun Zou, Shweta Modgil, Wenhao H. Shang, Nicole Y. Tsai, Zhishun Cai, Liping Liu, Guiying Hong, Arnold R. Kriegstein, Yang Hu, Jakob Körbelin, Ruobing Zhang, Yaping Joyce Liao, Tyson N. Kim, Xin Ye, Xin Duan
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Spinal projecting neurons in rostral ventromedial medulla co-regulate motor and sympathetic tone Cell (IF 64.5) Pub Date : 2024-05-10 Zicong Zhang, Junfeng Su, Jing Tang, Leeyup Chung, Jessica C. Page, Carla C. Winter, Yuchu Liu, Evgenii Kegeles, Sara Conti, Yu Zhang, Jason Biundo, Joshua I. Chalif, Charles Y. Hua, Zhiyun Yang, Xue Yao, Yang Yang, Shuqiang Chen, Jan M. Schwab, Kuan Hong Wang, Chinfei Chen, Zhigang He
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The future of rapid and automated single-cell data analysis using reference mapping Cell (IF 64.5) Pub Date : 2024-05-09 Mohammad Lotfollahi, , Fabian J. Theis, Rahul Satija
As the number of single-cell datasets continues to grow rapidly, workflows that map new data to well-curated reference atlases offer enormous promise for the biological community. In this perspective, we discuss key computational challenges and opportunities for single-cell reference-mapping algorithms. We discuss how mapping algorithms will enable the integration of diverse datasets across disease
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Analysis of 3D pathology samples using weakly supervised AI Cell (IF 64.5) Pub Date : 2024-05-09 Andrew H. Song, Mane Williams, Drew F.K. Williamson, Sarah S.L. Chow, Guillaume Jaume, Gan Gao, Andrew Zhang, Bowen Chen, Alexander S. Baras, Robert Serafin, Richard Colling, Michelle R. Downes, Xavier Farré, Peter Humphrey, Clare Verrill, Lawrence D. True, Anil V. Parwani, Jonathan T.C. Liu, Faisal Mahmood
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The phosphorylation landscape of infection-related development by the rice blast fungus Cell (IF 64.5) Pub Date : 2024-05-09 Neftaly Cruz-Mireles, Miriam Osés-Ruiz, Paul Derbyshire, Clara Jégousse, Lauren S. Ryder, Mark Jave A. Bautista, Alice Eseola, Jan Sklenar, Bozeng Tang, Xia Yan, Weibin Ma, Kim C. Findlay, Vincent Were, Dan MacLean, Nicholas J. Talbot, Frank L.H. Menke
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Neurotransmitter classification from electron microscopy images at synaptic sites in Drosophila melanogaster Cell (IF 64.5) Pub Date : 2024-05-09 Nils Eckstein, Alexander Shakeel Bates, Andrew Champion, Michelle Du, Yijie Yin, Philipp Schlegel, Alicia Kun-Yang Lu, Thomson Rymer, Samantha Finley-May, Tyler Paterson, Ruchi Parekh, Sven Dorkenwald, Arie Matsliah, Szi-Chieh Yu, Claire McKellar, Amy Sterling, Katharina Eichler, Marta Costa, Sebastian Seung, Mala Murthy, Jan Funke
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Circadian tumor infiltration and function of CD8+ T cells dictate immunotherapy efficacy Cell (IF 64.5) Pub Date : 2024-05-08 Chen Wang, Qun Zeng, Zeynep Melis Gül, Sisi Wang, Robert Pick, Phil Cheng, Ruben Bill, Yan Wu, Stefan Naulaerts, Coline Barnoud, Pei-Chun Hsueh, Sofie Hedlund Moller, Mara Cenerenti, Mengzhu Sun, Ziyang Su, Stéphane Jemelin, Volodymyr Petrenko, Charna Dibner, Stéphanie Hugues, Camilla Jandus, Christoph Scheiermann
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Deep mutational scanning of hepatitis B virus reveals a mechanism for cis-preferential reverse transcription Cell (IF 64.5) Pub Date : 2024-05-08 Yingpu Yu, Maximilian A. Kass, Mengyin Zhang, Noor Youssef, Catherine A. Freije, Kelly P. Brock, Lauren C. Aguado, Leon L. Seifert, Sanjana Venkittu, Xupeng Hong, Amir Shlomai, Ype P. de Jong, Debora S. Marks, Charles M. Rice, William M. Schneider
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Mapping the cellular biogeography of human bone marrow niches using single-cell transcriptomics and proteomic imaging Cell (IF 64.5) Pub Date : 2024-05-06 Shovik Bandyopadhyay, Michael P. Duffy, Kyung Jin Ahn, Jonathan H. Sussman, Minxing Pang, David Smith, Gwendolyn Duncan, Iris Zhang, Jeffrey Huang, Yulieh Lin, Barbara Xiong, Tamjid Imtiaz, Chia-Hui Chen, Anusha Thadi, Changya Chen, Jason Xu, Melissa Reichart, Zachary Martinez, Caroline Diorio, Chider Chen, Kai Tan
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FLT3L governs the development of partially overlapping hematopoietic lineages in humans and mice Cell (IF 64.5) Pub Date : 2024-05-03 Mana Momenilandi, Romain Lévy, Steicy Sobrino, Jingwei Li, Chantal Lagresle-Peyrou, Hossein Esmaeilzadeh, Antoine Fayand, Corentin Le Floc’h, Antoine Guérin, Erika Della Mina, Debra Shearer, Ottavia M. Delmonte, Ahmad Yatim, Kevin Mulder, Mathieu Mancini, Darawan Rinchai, Adeline Denis, Anna-Lena Neehus, Karla Balogh, Sarah Brendle, Vivien Béziat
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Small-molecule-induced epigenetic rejuvenation promotes SREBP condensation and overcomes barriers to CNS myelin regeneration Cell (IF 64.5) Pub Date : 2024-05-02 Xuezhao Liu, Dazhuan Eric Xin, Xiaowen Zhong, Chuntao Zhao, Zhidan Li, Liguo Zhang, Adam J. Dourson, Lindsay Lee, Shreya Mishra, Arman E. Bayat, Eva Nicholson, William L. Seibel, Bingfang Yan, Joel Mason, Bradley J. Turner, David G. Gonsalvez, William Ong, Sing Yian Chew, Balaram Ghosh, Sung Ok Yoon, Q. Richard Lu
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A transcription factor atlas of directed differentiation Cell (IF 64.5) Pub Date : 2024-05-02 Julia Joung, Sai Ma, Tristan Tay, Kathryn R. Geiger-Schuller, Paul C. Kirchgatterer, Vanessa K. Verdine, Baolin Guo, Mario A. Arias-Garcia, William E. Allen, Ankita Singh, Olena Kuksenko, Omar O. Abudayyeh, Jonathan S. Gootenberg, Zhanyan Fu, Rhiannon K. Macrae, Jason D. Buenrostro, Aviv Regev, Feng Zhang
No Abstract
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RNA aggregates harness the danger response for potent cancer immunotherapy Cell (IF 64.5) Pub Date : 2024-05-01 Hector R. Mendez-Gomez, Anna DeVries, Paul Castillo, Christina von Roemeling, Sadeem Qdaisat, Brian D. Stover, Chao Xie, Frances Weidert, Chong Zhao, Rachel Moor, Ruixuan Liu, Dhruvkumar Soni, Elizabeth Ogando-Rivas, Jonathan Chardon-Robles, James McGuiness, Dingpeng Zhang, Michael C. Chung, Christiano Marconi, Stephen Michel, Arnav Barpujari, Elias J. Sayour
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From periphery to center stage: 50 years of advancements in innate immunity Cell (IF 64.5) Pub Date : 2024-04-25 Susan Carpenter, Luke A.J. O’Neill
Over the past 50 years in the field of immunology, something of a Copernican revolution has happened. For a long time, immunologists were mainly concerned with what is termed adaptive immunity, which involves the exquisitely specific activities of lymphocytes. But the other arm of immunity, so-called “innate immunity,” had been neglected. To celebrate ’s 50 anniversary, we have put together a review
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Principles and therapeutic applications of adaptive immunity Cell (IF 64.5) Pub Date : 2024-04-25 Hongbo Chi, Marion Pepper, Paul G. Thomas
Adaptive immunity provides protection against infectious and malignant diseases. These effects are mediated by lymphocytes that sense and respond with targeted precision to perturbations induced by pathogens and tissue damage. Here, we review key principles underlying adaptive immunity orchestrated by distinct T cell and B cell populations and their extensions to disease therapies. We discuss the intracellular
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Exploring new perspectives in immunology Cell (IF 64.5) Pub Date : 2024-04-25 Ruslan Medzhitov, Akiko Iwasaki
Several conceptual pillars form the foundation of modern immunology, including the clonal selection theory, antigen receptor diversity, immune memory, and innate control of adaptive immunity. However, some immunological phenomena cannot be explained by the current framework. Thus, we still do not know how to design vaccines that would provide long-lasting protective immunity against certain pathogens
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The plant immune system: From discovery to deployment Cell (IF 64.5) Pub Date : 2024-04-25 Jonathan D.G. Jones, Brian J. Staskawicz, Jeffery L. Dangl
Plant diseases cause famines, drive human migration, and present challenges to agricultural sustainability as pathogen ranges shift under climate change. Plant breeders discovered Mendelian genetic loci conferring disease resistance to specific pathogen isolates over 100 years ago. Subsequent breeding for disease resistance underpins modern agriculture and, along with the emergence and focus on model
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Many paths lead to immunology Cell (IF 64.5) Pub Date : 2024-04-25 Ana J. García-Sáez, Ana I. Domingos, J. Silvio Gutkind, Seema Mattoo, Peng Du
While some people pore over the textbook and train through the classics of the field, many scientists come to immunology when they discover it intersecting with their “first love” interests. Five of these “accidental immunologists” tell us how they found their way to a fascination with the immune system.
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A glycolytic metabolite that drives BRCA2 haploinsufficiency Cell (IF 64.5) Pub Date : 2024-04-25 Peng Jiang
Many types of tumor cells alter metabolic pathways to meet their energy and biosynthetic demands for proliferation or stress adaptation. In this issue of Cell, Kong et al. find that the glycolytic metabolite methylglyoxal causes cancer-associated mutant single-base substitution features by inducing BRCA2 proteolysis, leading to functional haploinsufficiency of BRCA2.
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Mapping the pancancer metastasis tumor microbiome Cell (IF 64.5) Pub Date : 2024-04-25 Chi Chun Wong, Jun Yu
The landscape of the intratumoral microbiome in tumor metastases is largely unchartered. In this issue of Cell, Voest et al. profiled the tumor metastasis-associated microbiome in a pancancer cohort of 4,160 biopsies from 26 cancer types. This dataset offers a useful resource for understanding the role of the microbiome in metastatic cancers.
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Generation of rat forebrain tissues in mice Cell (IF 64.5) Pub Date : 2024-04-25 Jia Huang, Bingbing He, Xiali Yang, Xin Long, Yinghui Wei, Leijie Li, Min Tang, Yanxia Gao, Yuan Fang, Wenqin Ying, Zikang Wang, Chao Li, Yingsi Zhou, Shuaishuai Li, Linyu Shi, Seungwon Choi, Haibo Zhou, Fan Guo, Hui Yang, Jun Wu
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Functional sensory circuits built from neurons of two species Cell (IF 64.5) Pub Date : 2024-04-25 Benjamin T. Throesch, Muhammad Khadeesh bin Imtiaz, Rodrigo Muñoz-Castañeda, Masahiro Sakurai, Andrea L. Hartzell, Kiely N. James, Alberto R. Rodriguez, Greg Martin, Giordano Lippi, Sergey Kupriyanov, Zhuhao Wu, Pavel Osten, Juan Carlos Izpisua Belmonte, Jun Wu, Kristin K. Baldwin
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Positive selection CRISPR screens reveal a druggable pocket in an oligosaccharyltransferase required for inflammatory signaling to NF-κB Cell (IF 64.5) Pub Date : 2024-04-25 Benjamin L. Lampson, Ana S. Ramίrez, Marta Baro, Lixia He, Mudra Hegde, Vidyasagar Koduri, Jamie L. Pfaff, Ruth E. Hanna, Julia Kowal, Nitin H. Shirole, Yanfeng He, John G. Doench, Joseph N. Contessa, Kaspar P. Locher, William G. Kaelin Jr.
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Synthetic protein circuits for programmable control of mammalian cell death Cell (IF 64.5) Pub Date : 2024-04-23 Shiyu Xia, Andrew C. Lu, Victoria Tobin, Kaiwen Luo, Lukas Moeller, D. Judy Shon, Rongrong Du, James M. Linton, Margaret Sui, Felix Horns, Michael B. Elowitz
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IGSF8 is an innate immune checkpoint and cancer immunotherapy target Cell (IF 64.5) Pub Date : 2024-04-23 Yulong Li, Xiangyang Wu, Caibin Sheng, Hailing Liu, Huizhu Liu, Yixuan Tang, Chao Liu, Qingyang Ding, Bin Xie, Xi Xiao, Rongbin Zheng, Quan Yu, Zengdan Guo, Jian Ma, Jin Wang, Jinghong Gao, Mei Tian, Wei Wang, Jia Zhou, Li Jiang, Tengfei Xiao
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3D reconstruction of a gastrulating human embryo Cell (IF 64.5) Pub Date : 2024-04-23 Zhenyu Xiao, Lina Cui, Yang Yuan, Nannan He, Xinwei Xie, Sirui Lin, Xiaolong Yang, Xin Zhang, Peifu Shi, Zhifeng Wei, Yang Li, Hongmei Wang, Xiaoyan Wang, Yulei Wei, Jingtao Guo, Leqian Yu
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Hematopoietic stem cell niche generation and maintenance are distinguishable by an epitranscriptomic program Cell (IF 64.5) Pub Date : 2024-04-23 Longfei Gao, Heather Lee, Joshua H. Goodman, Lei Ding
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Gut symbionts alleviate MASH through a secondary bile acid biosynthetic pathway Cell (IF 64.5) Pub Date : 2024-04-22 Qixing Nie, Xi Luo, Kai Wang, Yong Ding, Shumi Jia, Qixiang Zhao, Meng Li, Jinxin Zhang, Yingying Zhuo, Jun Lin, Chenghao Guo, Zhiwei Zhang, Huiying Liu, Guangyi Zeng, Jie You, Lulu Sun, Hua Lu, Ming Ma, Yanxing Jia, Ming-Hua Zheng, Changtao Jiang
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Continuous germinal center invasion contributes to the diversity of the immune response Cell (IF 64.5) Pub Date : 2024-04-23 Thomas Hägglöf, Melissa Cipolla, Maximilian Loewe, Spencer T. Chen, Ervin E. Kara, Luka Mesin, Harald Hartweger, Mohamed A. ElTanbouly, Alice Cho, Anna Gazumyan, Victor Ramos, Leonidas Stamatatos, Thiago Y. Oliveira, Michel C. Nussenzweig, Charlotte Viant
No Abstract
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DrugMap: A quantitative pan-cancer analysis of cysteine ligandability Cell (IF 64.5) Pub Date : 2024-04-22 Mariko Takahashi, Harrison B. Chong, Siwen Zhang, Tzu-Yi Yang, Matthew J. Lazarov, Stefan Harry, Michelle Maynard, Brendan Hilbert, Ryan D. White, Heather E. Murrey, Chih-Chiang Tsou, Kira Vordermark, Jonathan Assaad, Magdy Gohar, Benedikt R. Dürr, Marianne Richter, Himani Patel, Gregory Kryukov, Natasja Brooijmans, Aliyu Sidi Omar Alghali, Liron Bar-Peled
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Integrative spatial analysis reveals a multi-layered organization of glioblastoma Cell (IF 64.5) Pub Date : 2024-04-22 Alissa C. Greenwald, Noam Galili Darnell, Rouven Hoefflin, Dor Simkin, Christopher W. Mount, L. Nicolas Gonzalez Castro, Yotam Harnik, Sydney Dumont, Dana Hirsch, Masashi Nomura, Tom Talpir, Merav Kedmi, Inna Goliand, Gioele Medici, Julie Laffy, Baoguo Li, Vamsi Mangena, Hadas Keren-Shaul, Michael Weller, Yoseph Addadi, Itay Tirosh
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Evasion of NKG2D-mediated cytotoxic immunity by sarbecoviruses Cell (IF 64.5) Pub Date : 2024-04-22 Jordan A. Hartmann, Marcella R. Cardoso, Maria Cecilia Ramiro Talarico, Devin J. Kenney, Madison R. Leone, Dagny C. Reese, Jacquelyn Turcinovic, Aoife K. O’Connell, Hans P. Gertje, Caitlin Marino, Pedro E. Ojeda, Erich V. De Paula, Fernanda A. Orsi, Licio Augusto Velloso, Thomas R. Cafiero, John H. Connor, Alexander Ploss, Angelique Hoelzemer, Mary Carrington, Amy K. Barczak, Wilfredo F. Garcia-Beltran
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Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis Cell (IF 64.5) Pub Date : 2024-04-22 Zhi Zong, Feng Xie, Shuai Wang, Xiaojin Wu, Zhenyu Zhang, Bing Yang, Fangfang Zhou
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BCAA-nitrogen flux in brown fat controls metabolic health independent of thermogenesis Cell (IF 64.5) Pub Date : 2024-04-22 Anthony R.P. Verkerke, Dandan Wang, Naofumi Yoshida, Zachary H. Taxin, Xu Shi, Shuning Zheng, Yuka Li, Christopher Auger, Satoshi Oikawa, Jin-Seon Yook, Melia Granath-Panelo, Wentao He, Guo-Fang Zhang, Mami Matsushita, Masayuki Saito, Robert E. Gerszten, Evanna L. Mills, Alexander S. Banks, Yasushi Ishihama, Phillip J. White, Shingo Kajimura
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Dual-role transcription factors stabilize intermediate expression levels Cell (IF 64.5) Pub Date : 2024-04-16 Jinnan He, Xiangru Huo, Gaofeng Pei, Zeran Jia, Yiming Yan, Jiawei Yu, Haozhi Qu, Yunxin Xie, Junsong Yuan, Yuan Zheng, Yanyan Hu, Minglei Shi, Kaiqiang You, Tingting Li, Tianhua Ma, Michael Q. Zhang, Sheng Ding, Pilong Li, Yinqing Li
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Global, site-resolved analysis of ubiquitylation occupancy and turnover rate reveals systems properties Cell (IF 64.5) Pub Date : 2024-04-15 Gabriela Prus, Shankha Satpathy, Brian T. Weinert, Takeo Narita, Chunaram Choudhary
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Creating connections when we talk about science Cell (IF 64.5) Pub Date : 2024-04-15
For Cell’s 50th anniversary Focus on Immunology, scientific editor Cheri Sirois asked science communicator Liz Neeley, founding partner of Liminal and cofounder of Solving for Science, to discuss strategies for tackling technical complexity and for engaging effectively with broad audiences. A lightly edited transcript of their conversation is shared here.
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Direct observation of a condensate effect on super-enhancer controlled gene bursting Cell (IF 64.5) Pub Date : 2024-04-12 Manyu Du, Simon Hendrik Stitzinger, Jan-Hendrik Spille, Won-Ki Cho, Choongman Lee, Mohammed Hijaz, Andrea Quintana, Ibrahim I. Cissé
Abstract not available
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RNA genome packaging and capsid assembly of bluetongue virus visualized in host cells Cell (IF 64.5) Pub Date : 2024-04-12 Xian Xia, Po-Yu Sung, Michael W. Martynowycz, Tamir Gonen, Polly Roy, Z. Hong Zhou
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ITPRIPL1 binds CD3ε to impede T cell activation and enable tumor immune evasion Cell (IF 64.5) Pub Date : 2024-04-12 Shouyan Deng, Yibo Zhang, Huanbin Wang, Wenhua Liang, Lu Xie, Ning Li, Yuan Fang, Yiting Wang, Jiayang Liu, Hao Chi, Yufan Sun, Rui Ye, Lishen Shan, Jiawei Shi, Zan Shen, Yonggang Wang, Shuhang Wang, Jean-Philippe Brosseau, Feng Wang, Grace Liu, Yingfei Quan, Jie Xu
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NINJ1 mediates plasma membrane rupture by cutting and releasing membrane disks Cell (IF 64.5) Pub Date : 2024-04-12 Liron David, Jazlyn P. Borges, L. Robert Hollingsworth, Allen Volchuk, Isabelle Jansen, Evelyn Garlick, Benjamin E. Steinberg, Hao Wu
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Ending “domestic helicopter research” Cell (IF 64.5) Pub Date : 2024-04-11 W. Marcus Lambert, Marlene Camacho-Rivera, Carla Boutin-Foster, Moro Salifu, Wayne J. Riley
“Helicopter research” refers to a practice where researchers from wealthier countries conduct studies in lower-income countries with little involvement of local researchers or community members. This practice also occurs domestically. In this Commentary, we outline strategies to curb domestic helicopter research and to foster equity-centered collaborations.
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Problem choice and decision trees in science and engineering Cell (IF 64.5) Pub Date : 2024-04-11 Michael A. Fischbach
Scientists and engineers often spend days choosing a problem and years solving it. This imbalance limits impact. Here, we offer a framework for problem choice: prompts for ideation, guidelines for evaluating impact and likelihood of success, the importance of fixing one parameter at a time, and opportunities afforded by failure.
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Self-amplifying RNA COVID-19 vaccine Cell (IF 64.5) Pub Date : 2024-04-11 Christopher J. Wayne, Anna K. Blakney
In November 2023, Japan’s Ministry of Health, Labour and Welfare granted regulatory approval of ARCT-154, a self-amplifying RNA COVID-19 vaccine developed by Arcturus Therapeutics. Clinical trials showed comparable safety and efficacy using a lower dose compared to the mRNA vaccine BNT162b2. To view this Bench-to-Bedside, open or download the PDF.
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Elliott Dan Kieff, MD, PhD (1943–2024) Cell (IF 64.5) Pub Date : 2024-04-11 Nancy Raab-Traub, Benjamin E. Gewurz
Abstract not available
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Chromatin context-dependent regulation and epigenetic manipulation of prime editing Cell (IF 64.5) Pub Date : 2024-04-11 Xiaoyi Li, Wei Chen, Beth K. Martin, Diego Calderon, Choli Lee, Junhong Choi, Florence M. Chardon, Troy A. McDiarmid, Riza M. Daza, Haedong Kim, Jean-Benoît Lalanne, Jenny F. Nathans, David S. Lee, Jay Shendure
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A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 Cell (IF 64.5) Pub Date : 2024-04-11 Li Ren Kong, Komal Gupta, Andy Jialun Wu, David Perera, Roland Ivanyi-Nagy, Syed Moiz Ahmed, Tuan Zea Tan, Shawn Lu-Wen Tan, Alessandra Fuddin, Elayanambi Sundaramoorthy, Grace Shiqing Goh, Regina Tong Xin Wong, Ana S.H. Costa, Callum Oddy, Hannan Wong, C. Pawan K. Patro, Yun Suen Kho, Xiao Zi Huang, Joan Choo, Mona Shehata, Soo Chin Lee, Boon Cher Goh, Christian Frezza, Jason J. Pitt, Ashok R. Venkitaraman
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Time-series reconstruction of the molecular architecture of human centriole assembly Cell (IF 64.5) Pub Date : 2024-04-10 Marine H. Laporte, Davide Gambarotto, Éloïse Bertiaux, Lorène Bournonville, Vincent Louvel, José M. Nunes, Susanne Borgers, Virginie Hamel, Paul Guichard
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A pan-cancer analysis of the microbiome in metastatic cancer Cell (IF 64.5) Pub Date : 2024-04-09 Thomas W. Battaglia, Iris L. Mimpen, Joleen J.H. Traets, Arne van Hoeck, Laurien J. Zeverijn, Birgit S. Geurts, Gijs F. de Wit, Michaël Noë, Ingrid Hofland, Joris L. Vos, Sten Cornelissen, Maartje Alkemade, Annegien Broeks, Charlotte L. Zuur, Edwin Cuppen, Lodewyk Wessels, Joris van de Haar, Emile Voest
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A genome-wide spectrum of tandem repeat expansions in 338,963 humans Cell (IF 64.5) Pub Date : 2024-04-05 Ya Cui, Wenbin Ye, Jason Sheng Li, Jingyi Jessica Li, Eric Vilain, Tamer Sallam, Wei Li
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Human iPSC 4R tauopathy model uncovers modifiers of tau propagation Cell (IF 64.5) Pub Date : 2024-04-05 Celeste Parra Bravo, Alice Maria Giani, Jesus Madero-Perez, Zeping Zhao, Yuansong Wan, Avi J. Samelson, Man Ying Wong, Alessandro Evangelisti, Ethan Cordes, Li Fan, Pearly Ye, Daphne Zhu, Tatyana Pozner, Maria Mercedes, Tark Patel, Allan Yarahmady, Gillian K. Carling, Fredrik H. Sterky, Virginia M.Y. Lee, Edward B. Lee, Li Gan
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Tracing the origin of alveolar stem cells in lung repair and regeneration Cell (IF 64.5) Pub Date : 2024-04-04 Kuo Liu, Xinfeng Meng, Zixin Liu, Muxue Tang, Zan Lv, Xiuzhen Huang, Hengwei Jin, Ximeng Han, Xiuxiu Liu, Wenjuan Pu, Huan Zhu, Bin Zhou
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Infant microbes and metabolites point to childhood neurodevelopmental disorders Cell (IF 64.5) Pub Date : 2024-04-03 Angelica P. Ahrens, Tuulia Hyötyläinen, Joseph R. Petrone, Kajsa Igelström, Christian D. George, Timothy J. Garrett, Matej Orešič, Eric W. Triplett, Johnny Ludvigsson
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Gut microbiome and metabolome profiling in Framingham heart study reveals cholesterol-metabolizing bacteria Cell (IF 64.5) Pub Date : 2024-04-02 Chenhao Li, Martin Stražar, Ahmed M.T. Mohamed, Julian A. Pacheco, Rebecca L. Walker, Tina Lebar, Shijie Zhao, Julia Lockart, Andrea Dame, Kumar Thurimella, Sarah Jeanfavre, Eric M. Brown, Qi Yan Ang, Brittany Berdy, Dallis Sergio, Rachele Invernizzi, Antonio Tinoco, Gleb Pishchany, Ramachandran S. Vasan, Emily Balskus, Ramnik J. Xavier
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Charting the cellular biogeography in colitis reveals fibroblast trajectories and coordinated spatial remodeling Cell (IF 64.5) Pub Date : 2024-04-02 Paolo Cadinu, Kisha N. Sivanathan, Aditya Misra, Rosalind J. Xu, Davide Mangani, Evan Yang, Joseph M. Rone, Katherine Tooley, Yoon-Chul Kye, Lloyd Bod, Ludwig Geistlinger, Tyrone Lee, Randall T. Mertens, Noriaki Ono, Gang Wang, Liliana Sanmarco, Francisco J. Quintana, Ana C. Anderson, Vijay K. Kuchroo, Jeffrey R. Moffitt, Roni Nowarski