当前期刊:
European Journal of Medicinal Chemistry
Go to
current issue
加入关注
本刊介绍/投稿指南
催更
样式: 排序: IF: - GO 导出 标记为已读
样式: 排序: IF: - GO 导出 标记为已读
-
Macrocyclization strategy for improving candidate profiles in medicinal chemistry Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-05-14 Om Darlami, Rabin Pun, Sung-Hoon Ahn, Seok-Ho Kim, Dongyun Shin
-
Novel angiogenesis inhibitors with superoxide anion radical amplification effect: Surmounting the Achilles’ heels of angiogenesis inhibitors and photosensitizers Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-05-11 Kai Wang, Junhua Liu, Ping Hai, Wei Zhang, Yuanyuan Shan, Jie Zhang
-
Discovery of an efficacious KDM5B PROTAC degrader GT-653 up-regulating IFN response genes in prostate cancer Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-05-10 Tian Guan, Yingshuang Zhang, Shen Li, Wenbao Zhang, Yuxuan Song, Yuzhan Li, Yundong He, Yihua Chen
-
Development of novel N-aryl-2,4-bithiazole-2-amine-based CYP1B1 degraders for reversing drug resistance Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-05-08 Xiaoxuan Yao, Jianping Mao, Haoyu Zhang, Yi Xiao, Yongjun Wang, Hongzhuo Liu
-
Recent advances in c-Met-based dual inhibitors in the treatment of cancers Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-05-08 Fanqi Jin, Yihan Lin, Weidong Yuan, Shuang Wu, Min Yang, Shi Ding, Ju Liu, Ye Chen
-
New synergistic benzoquinone scaffolds as inhibitors of mycobacterial cytochrome bc1 complex to treat multi-drug resistant tuberculosis Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-05-07 Naresh Babu Chilamakuru, Azger Dusthackeer VN, Varadaraj Bhat G, Nikhil Pallaprolu, Aishwarya Dande, Dina Nair, Raghuveer Varma Pemmadi, Padmanabha Reddy Y, Ramalingam Peraman
-
Recent advances and future directions on small molecule VEGFR inhibitors in oncological conditions Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-05-06 Amandeep Thakur, Mandeep Rana, Anshul Mishra, Charanjit Kaur, Chun-Hsu Pan, Kunal Nepali
-
Discovery of potent small molecule ubiquitin-specific protease 10 inhibitors with anti-hepatocellular carcinoma activity through regulating YAP expression Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-05-05 Yang Lu, Jian Gao, Peipei Wang, Haifeng Chen, Xinjun He, Mengxin Luo, Yu Guo, Linjie Li, Weihao Zhuang, Bo Zhang, Nengming Lin, Jia Li, Yubo Zhou, Xiaowu Dong, Jinxin Che
-
Inhibitory interactions of the 2,3-dihydro-6,7-dihydroxy-1H-isoindol-1-one scaffold with Bunyavirales cap-snatching endonucleases expose relevant drug design features Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-05-04 Francesca Miglioli, Shindhuja Joel, Matteo Tegoni, Pedro Neira-Pelén, Stephan Günther, Mauro Carcelli, Emilia Fisicaro, Andrea Brancale, Yaiza Fernández-García, Dominga Rogolino
-
Anticancer activity of 8-hydroxyquinoline-triphenylphosphine rhodium(III) complexes targeting mitophagy pathways Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-05-04 Xiao-Qiong Huang, Run-Chun Wu, Jian-Min Liang, Zhen Zhou, Qi-Pin Qin, Hong Liang
-
Discovery of LHQ490 as a highly selective fibroblast growth factor receptor 2 (FGFR2) inhibitor Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-05-04 Huiqiong Li, Ran Ke, Yang Zhou, Shaohua Chang, Jie Wang, Chen Su, Pinglian Wu, Bowen Yang, Zhen Wang, Ke Ding, Dawei Ma
-
Design, synthesis, and evaluation of N1,N3-dialkyldioxonaphthoimidazoliums as antibacterial agents against methicillin-resistant Staphylococcus aureus Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-05-04 Taewoo Kim, Shin-Yae Choi, Hee-Won Bae, Hyun Su Kim, Hoon Jeon, Haejun Oh, Sung-Hoon Ahn, Jongkook Lee, Young-Ger Suh, You-Hee Cho, Seok-Ho Kim
-
Dihydroxanthene-based monoamine oxidase A-activated photosensitizers for photodynamic/photothermal therapy of tumors Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-05-03 Qingyuan Mo, Tiantian Zhong, Bingying Cao, Zhongyao Han, Xianyun Hu, Shulin Zhao, Xiaoyu Wei, Zhengmin Yang, Jiangke Qin
-
Recent discovery and development of AXL inhibitors as antitumor agents Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-05-03 Zihang Liu, Li Chen, Jifa Zhang, Jun Yang, Xue Xiao, Lianhai Shan, Wuyu Mao
-
Synthesis and Evaluation of diaryl ether modulators of the leukotriene A4 hydrolase aminopeptidase activity Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-05-03 Greg Petruncio, Kyung Hyeon Lee, Michael Girgis, Zachary Shellnutt, Zach Beaulac, Jiangdong Xiang, Soo Hyeon Lee, Xuejun Peng, Marie Burdick, Schroeder M. Noble, Yun M. Shim, Mikell Paige
-
Novel pyxinol amide derivatives bearing an aliphatic heterocycle as P-glycoprotein modulators for overcoming multidrug resistance Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-05-01 Liping Yu, Ruiyin Ren, Shuang Li, Chen Zhang, Cheng Chen, Hanqi Lv, Zongji Zou, Xinjie Pei, Zhihua Song, Peng Zhang, Hongbo Wang, Gangqiang Yang
-
Synthesis and clinical application of representative small-molecule dipeptidyl Peptidase-4 (DPP-4) inhibitors for the treatment of type 2 diabetes mellitus (T2DM) Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-05-01 Dong-Wei Shao, Li-Jie Zhao, Jin-Feng Sun
-
Research progress of prodrugs for the treatment of cerebral ischemia Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-05-01 Hongwei Zheng, Hongmei Wu, Dezhi Wang, Sijia Wang, Dongliang Ji, Xiao Liu, Ge Gao, Xing Su, Yanan Zhang, Yong Ling
-
Analogues of the pan-selectin antagonist rivipansel (GMI-1070) Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-04-30 Beatrice Wagner, Martin Smieško, Roman P. Jakob, Tobias Mühlethaler, Jonathan Cramer, Tim Maier, Said Rabbani, Oliver Schwardt, Beat Ernst
-
Recent advances of honokiol:pharmacological activities, manmade derivatives and structure-activity relationship Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-04-30 Xiuxia Li, Zhuo Yuan, Yuxia Wang, Wenjing Wang, Jianyou Shi
-
An oleanic acid decorated gold nanorod for highly efficient inhibition of hemagglutinin and visible rapid detection of the influenza virus Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-04-30 Ming Zhong, Qian-Jiong Huang, Yan-Bin Bao, Jia-Ning Wang, Xue Mi, Hao Chang, Yang Yang
-
Antiviral drug discovery: Pyrimidine entry inhibitors for Zika and dengue viruses Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-04-30 Facundo N. Gallo, Agostina B. Marquez, Daniela M. Fidalgo, Alejandro Dana, Mariano Dellarole, Cybele C. García, Mariela Bollini
-
Discovery of 4-benzylpiperazinequinoline BChE inhibitor that suppresses neuroinflammation for the treatment of Alzheimer's disease Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-04-30 Ying Chen, Weiting Zhang, Qi Li, Huanfang Xie, Shuaishuai Xing, Xin Lu, Weiping Lyu, Baichen Xiong, Yuanyuan Wang, Wei Qu, Wenyuan Liu, Heng Chi, Xiaolong Zhang, Feng Feng, Haopeng Sun
-
Exploration of novel isoxazole-fused quinone derivatives as anti-colorectal cancer agents through inhibiting STAT3 and elevating ROS level Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-04-30 Lidan Zhang, Pingxian Liu, Yunhan Jiang, Dongmei Fan, Xinlian He, Jiangnan Zhang, Baozhu Luo, Jing Sui, Youfu Luo, Xinyuan Fu, Tao Yang
-
Design, synthesis and biological evaluation of novel tubulin-targeting agents with a dual-mechanism for polymerization inhibition and protein degradation Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-04-28 Sibo Wang, Jiahao Wang, Xiankun Lu, Meitong Liu, Yue Liu, Mi Li, Xuejie Kong, Lan Wu, Qi Guan, Weige Zhang
-
Update on the development of TGR5 agonists for human diseases Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-04-28 Wangrui Jin, Mingyue Zheng, Yihua Chen, Hai Xiong
-
Targeting the cysteine biosynthesis pathway in microorganisms: Mechanism, structure, and drug discovery Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-04-28 Ying Tao, Dandan Zheng, Wei Zou, Ting Guo, Guojian Liao, Wei Zhou
-
An insight into the pharmacology of cysteine/methionine containing peptide drugs Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-04-28 Anamika Sharma, L. Ravithej Singh
-
Design, synthesis and molecular modeling of novel D-ring substituted steroidal 4,5-dihydropyrazole thiazolinone derivatives as anti-inflammatory agents by inhibition of COX-2/iNOS production and down-regulation of NF-κB/MAPKs in LPS-induced RAW264.7 macrophage cells Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-04-27 Xiaorui Cai, Jianfeng Cai, Ling Fang, Siqi Xu, Huide Zhu, Shuteng Wu, Yicun Chen, Shuopo Fang
-
Lead optimization based design, synthesis, and pharmacological evaluation of quinazoline derivatives as multi-targeting agents for Alzheimer's disease treatment Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-04-27 Akash Verma, Digambar Kumar Waiker, Neha Singh, Abhinav Singh, Poorvi Saraf, Bhagwati Bhardwaj, Pradeep Kumar, Sairam Krishnamurthy, Saripella Srikrishna, Sushant Kumar Shrivastava
-
Preclinical evaluation of AGTR1-Targeting molecular probe for colorectal cancer imaging in orthotopic and liver metastasis mouse models Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-04-27 Kuncheng Zhou, Gang Li, Rongbin Pan, Sulin Xin, Weijie Wen, Huiyi Wang, Chao Luo, Ray P.S. Han, Yueqing Gu, Yuanbiao Tu
-
Arginine and tryptophan-rich dendritic antimicrobial peptides that disrupt membranes for bacterial infection in vivo Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-04-27 Yinyin Yang, Zhongwei Yu, Zufang Ba, Xu Ouyang, Beibei Li, Ping Yang, Jingying Zhang, Yu Wang, Yao Liu, Tingting Yang, Yuhuan Zhao, Xiaoyan Wu, Chao Zhong, Hui Liu, Yun Zhang, Sanhu Gou, Jingman Ni
-
Preferential HDAC6 inhibitors derived from HPOB exhibit synergistic antileukemia activity in combination with decitabine Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-04-26 Maik Tretbar, Julian Schliehe-Diecks, Lukas von Bredow, Kathrin Tan, Martin Roatsch, Jia-Wey Tu, Marie Kemkes, Melf Sönnichsen, Andrea Schöler, Arndt Borkhardt, Sanil Bhatia, Finn K. Hansen
-
Emerging ferroptosis inhibitors as a novel therapeutic strategy for the treatment of neonatal hypoxic-ischemic encephalopathy Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-04-26 Liang Huo, Jianhua Fu, Shimeng Wang, Hua Wang, Xueyan Liu
-
Novel natural osthole-inspired amphiphiles as membrane targeting antibacterials against methicillin-resistant Staphylococcus aureus (MRSA) Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-04-26 Ruige Yang, Zihan Xue, Xinhui Li, Ting Xu, Yan Zhong, Songlin Hu, Shangshang Qin, Yong Guo
-
Fluorine in the pharmaceutical industry: Synthetic approaches and application of clinically approved fluorine-enriched anti-infectious medications Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-04-26 Zhen-Xi Niu, Jing Hu, Jin-Feng Sun, Ya-Tao Wang
-
Discovery of potent and novel dual NAMPT/BRD4 inhibitors for efficient treatment of hepatocellular carcinoma Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-04-26 Chunjia Yin, Shuting Jia, Xiaojuan Yang, Liqiang Wu
-
Design, synthesis, and biological evaluation of 5-(1H-indol-5-yl)isoxazole-3-carboxylic acids as novel xanthine oxidase inhibitors Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-04-26 Dongqian Huang, Wenye Li, Yilan Zhao, Cheng Xie, Xiaogang Luo, Fengshou Wu, Zhiqiang Xu, Qi Sun, Genyan Liu
-
Sesquilignans: Current research and potential prospective Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-04-25 Ying Wu, Chao Ding, Zilong Zhang, Jiayi Zhang, Yuze Li, Xiaomei Song, Dongdong Zhang
-
Medicinal chemistry strategies toward broad-spectrum antiviral agents to prevent next pandemics Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-04-25 Zirui Lü, Xiandong Dai, Jianjie Xu, Zhenming Liu, Yongbiao Guo, Zhenhua Gao, Fanhua Meng
-
Improving tumor sensitivity by the introduction of an ester chain to triaryl derivatives targeting PD-1/PD-L1 Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-04-25 Yonglei Zhang, Fucheng Yin, Zhongwen Luo, Shang Li, Xinxin Li, Siyuan Wan, Yifan Chen, Lingyi Kong, Xiaobing Wang
-
High affinity and low PARP-trapping benzimidazole derivatives as a potential warhead for PARP1 degraders Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-04-25 Xiaoyu Peng, Yang Li, Junfeng Qu, Lizhi Jiang, Kaiyue Wu, Dan Liu, Yuping Chen, Junmei Peng, Yu Guo, Xuan Cao
-
Structure-based drug design of DNA minor groove binders and evaluation of their antibacterial and anticancer properties Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-04-24 Hasan Y. Alniss, Hadeel M. Al-Jubeh, Yousef A. Msallam, Ruqaiyyah Siddiqui, Zinb Makhlouf, Anil Ravi, Rania Hamdy, Sameh S.M. Soliman, Naveed A. Khan
-
From lab to nature: Recent advancements in the journey of gastroprotective agents from medicinal chemistry to phytotherapy Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-04-23 Susmita Yadav, Anima Pandey, Suraj N. Mali
-
Design, synthesis, and biological evaluation of novel sesquiterpene lactone derivatives as PKM2 activators with potent anti-ulcerative colitis activities Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-04-23 Lingyu Ma, Mengting Li, Jiahao Lv, Qingxin Yuan, Xunkai Yin, Wenyu Lu, Weijiang Lin, Ping Wang, Jian Cui, Qi Lv, Jian Liu, Lihong Hu
-
Discovery of novel ocotillol derivatives modulating glucocorticoid receptor/NF-κB signaling for the treatment of sepsis Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-04-23 Gongshan Ma, Xiaojin Gao, Xin Zhang, Haixia Li, Zhiyuan Geng, Jing Gao, Shuxin Yang, Zhiruo Sun, Yuqi Lin, Xiaomei Wen, Qingguo Meng, Leiming Zhang, Yi Bi
-
Perspectives and challenges in developing small molecules targeting purine nucleoside phosphorylase Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-04-20 Yangyang Chen, Yang Li, Jing Gao, Quanwei Yu, Yiwen Zhang, Jifa Zhang
-
Structure-activity relationship in NOD2 agonistic muramyl dipeptides Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-04-20 Aarzoo Kamboj, Madhuri T. Patil, Nikolai Petrovsky, Deepak B. Salunke
-
Advancements in steroidal Pt(II) & Pt(IV) derivatives for targeted chemotherapy (2000–2023) Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-04-20 Hamdullah Khadim Sheikh, Cindy Juliet Cristancho Ortiz, Tanzila Arshad, José M. Padrón, Haroon Khan
-
Research strategies of small molecules as chemotherapeutics to overcome multiple myeloma resistance Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-04-20 Jin Yang, Yan-Cheng Yu, Zi-Xuan Wang, Qing-Qing Li, Ning Ding, Xue-Jiao Leng, Jiao Cai, Meng-Yuan Zhang, Jing-Jing Wang, Yun Zhou, Tian-Hua Wei, Xin Xue, Wei-Chen Dai, Shan-Liang Sun, Ye Yang, Nian-Guang Li, Zhi-Hao Shi
-
Probing benzenesulfonamide–thiazolidinone hybrids as multitarget directed ligands for efficient control of type 2 diabetes mellitus through targeting the enzymes: α-glucosidase and carbonic anhydrase II Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-04-20 Mona A. Gamal, Samar H. Fahim, Simone Giovannuzzi, Marwa A. Fouad, Alessandro Bonardi, Paola Gratteri, Claudiu T. Supuran, Ghaneya S. Hassan
-
Identification of naphthalimide-derivatives as novel PBD-targeted polo-like kinase 1 inhibitors with efficacy in drug-resistant lung cancer cells Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-04-20 Pingping Li, Yongkun Li, Xuesong Ma, Liangping Li, Shulan Zeng, Yan Peng, Hong Liang, Guohai Zhang
-
Quinazolines annelated at the N(3)–C(4) bond: Synthesis and biological activity Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-04-18 Emiliya V. Nosova, Galina N. Lipunova, Yulia V. Permyakova, Valery N. Charushin
-
Benzothiazole derivatives as histone deacetylase inhibitors for the treatment of autosomal dominant polycystic kidney disease Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-04-18 Xudong Cao, Zhiyuan Fan, Lingfang Xu, Wenchao Zhao, Haoran Zhang, Yunfang Yang, Ying Ren, Yuxian Xiao, Nan Zhou, Long Yin, Xueyan Zhou, Xu Zhu, Dong Guo
-
Design, synthesis, and biological evaluation of 3-phenyl substituted pyridine derivatives as potential dual inhibitors of XOR and URAT1 Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-04-18 Chao Yang, Haojie Cai, Xinying Zhu, Lei Zhang, Jing Li
-
Discovery of N-(4-((6-(3,5- Dimethoxyphenyl)-9H-purine derivatives as irreversible covalent FGFR inhibitors Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-04-17 Yuanjiang Wang, Yanchang Pan, Zhaodan Lv, Shaohua Gou
-
Application of covalent modality in proximity-induced drug pharmacology: Early development, current strategy, and feature directions Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-04-17 Linjie Li, Song Liu, Youfu Luo
-
Discovery of novel diaryl substituted isoquinolin-1(2H)-one derivatives as hypoxia-inducible factor-1 signaling inhibitors for the treatment of rheumatoid arthritis Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-04-16 Li Cai, Peng-Fei Xiong, Tao Li, Chong Li, Zheng-Xing Wu, Ya-Ling Hong, Jin-Ting Wang, Meng-Yue Zhang, Xi-Qin Yang, Qian-Qian Xu, Huan Shi, Qi-Chao Luo, Rong Li, Ming-Ming Liu
-
Discovery of the small molecular inhibitors against sclerostin loop3 as potential anti-osteoporosis agents by structural based virtual screening and molecular design Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-04-16 Sifan Yu, Weifeng Huang, Hao Zhang, Yinfeng Guo, Baoting Zhang, Ge Zhang, Jinping Lei
-
Design, synthesis, and evaluation of novel quindoline derivatives with fork-shaped side chains as RNA G-quadruplex stabilizers for repressing oncogene NRAS translation Eur. J. Med. Chem. (IF 6.7) Pub Date : 2024-04-16 Jia-Wei Sun, Jing Zou, Ying Zheng, Hao Yuan, Yuan-Ze-Yu Xie, Xiao-Na Wang, Tian-Miao Ou