The liver, the largest internal organ in the human body, is crucial in maintaining health and vitality. Acute liver injury (ALI) is a condition characterised by the death of hepatocytes due to necrosis and/or apoptosis. ALI can progress into a more severe and life-threatening condition known as acute liver failure (ALF). The major causes of ALI/ALF are drug-induced liver injury (DILI), viral and parasitic infections and hepatic ischaemia-reperfusion (IR) injury.1 Hepatic IR injury is a significant cause of liver injury that occurs in a variety of clinical contexts, including system shock, liver resection and liver transplantation. The underlying mechanisms of hepatic IR injury include oxygen and adenosine triphosphate (ATP) depletion, excessive inflammation, and the generation of reactive oxygen species following reperfusion. Liver transplantation is the standard treatment for end-stage liver diseases and ALF depending on the aetiology of the disease. However, the shortage of donor organs has limited the practice of liver transplantation. To address this issue, there is a growing acceptance of the use of liver grafts from extended criteria donors (ECD), which encompasses donors with steatotic liver, advanced age and donation after cardiac death (DCD). However, the use of ECD organs carries an increased risk of IR injury and mortality after …

中文翻译：

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嗜酸性粒细胞：促进急性肝损伤肝再生的新治疗靶点？

肝脏是人体最大的内脏器官，对于维持健康和活力至关重要。急性肝损伤（ALI）是一种以肝细胞因坏死和/或凋亡而死亡为特征的疾病。 ALI 可能会发展为更严重且危及生命的疾病，称为急性肝衰竭 (ALF)。 ALI/ALF 的主要原因是药物性肝损伤 (DILI)、病毒和寄生虫感染以及肝缺血再灌注 (IR) 损伤。1 肝 IR 损伤是各种临床情况下发生的肝损伤的重要原因，包括系统休克、肝切除和肝移植。肝IR损伤的潜在机制包括氧和三磷酸腺苷(ATP)消耗、过度炎症以及再灌注后活性氧的产生。根据疾病的病因，肝移植是终末期肝病和 ALF 的标准治疗方法。然而，供体器官的短缺限制了肝移植的实践。为了解决这个问题，人们越来越接受使用扩展标准供体 (ECD) 的肝移植，其中包括患有脂肪肝、高龄和心源性死亡后捐献 (DCD) 的供体。然而，使用 ECD 器官会增加 IR 损伤和死亡的风险……