Lipid metabolism is important for the maintenance of physiological homeostasis. Several members of the small ubiquitin-like modifier (SUMO)-specific protease (SENP) family have been reported as the regulators of lipid homeostasis. However, the function of Senp7 in lipid metabolism remains unclear. In this study, we generated both conventional and adipocyte-specific KO mice to characterize the role of Senp7 in lipid metabolism homeostasis. Both -deficient mice displayed reduced white adipose tissue mass and decreased size of adipocytes. By analyzing the lipid droplet morphology, we demonstrated that the lipid droplet size was significantly smaller in -deficient adipocytes. Mechanistically, Senp7 could deSUMOylate the perilipin family protein Plin4 to promote the lipid droplet localization of Plin4. Our results reveal an important role of Senp7 in the maturation of lipid droplets Plin4 deSUMOylation.

中文翻译：

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Senp7 缺陷通过 Plin4 去SUMOylation 损害白色脂肪组织中的脂滴成熟


脂质代谢对于维持生理稳态很重要。小泛素样修饰剂 (SUMO) 特异性蛋白酶 (SENP) 家族的几个成员已被报道为脂质稳态的调节剂。然而，Senp7在脂质代谢中的功能仍不清楚。在这项研究中，我们生成了传统和脂肪细胞特异性 KO 小鼠，以表征 Senp7 在脂质代谢稳态中的作用。两种β-缺陷小鼠均表现出白色脂肪组织质量减少和脂肪细胞大小减少。通过分析脂滴形态，我们证明缺乏脂肪细胞中的脂滴尺寸明显更小。从机制上讲，Senp7可​​以去SUMO化perilipin家族蛋白Plin4，从而促进Plin4的脂滴定位。我们的结果揭示了 Senp7 在脂滴 Plin4 去SUMO化成熟中的重要作用。