Among the important properties of metal–organic frameworks (MOFs) is stability, which may limit applications, for example, in separations and catalysis. Many MOFs consist of metal oxo cluster nodes connected by carboxylate linkers. Addressing MOF stability, we highlight connections between metal oxo cluster chemistry and MOF node chemistry, including results characterizing Keggin ions and biological clusters. MOF syntheses yield diverse metal oxo cluster node structures, with varying numbers of metal atoms (3–13) and the tendency to form chains. MOF stabilities reflect a balance between the number of node–linker connections and the degree of node hydrolysis. We summarize literature results showing how MOF stability (the temperature of decomposition in air) depends on the degree of hydrolysis/condensation of the node metals, which is correlated to their degree of substitution with linkers. We suggest that this correlation may help guide the discovery of stable new MOFs, and we foresee opportunities for progress in MOF chemistry emerging from progress in metal oxo cluster chemistry.

中文翻译：

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分析金属有机框架的稳定性：稳定性与连接子的节点配位和节点金属水解程度的相关性

金属有机框架（MOF）的重要特性之一是稳定性，这可能会限制其在分离和催化等领域的应用。许多 MOF 由通过羧酸盐连接体连接的金属氧簇节点组成。针对 MOF 稳定性，我们强调了金属氧簇化学和 MOF 节点化学之间的联系，包括表征 Keggin 离子和生物簇的结果。 MOF 合成产生不同的金属氧簇节点结构，具有不同数量的金属原子 (3-13) 和形成链的倾向。 MOF 稳定性反映了节点-连接体连接数量和节点水解程度之间的平衡。我们总结了文献结果，显示 MOF 稳定性（空气中的分解温度）如何取决于节点金属的水解/缩合程度，这与它们与连接体的取代程度相关。我们认为这种相关性可能有助于指导稳定的新型 MOF 的发现，并且我们预见金属氧簇化学的进展将带来 MOF 化学进展的机会。