Intracranial implants for diagnosis and treatment of brain diseases have been developed over the past few decades. However, the platform of conventional implantable devices still relies on invasive probes and bulky sensors in conjunction with large-area craniotomy and provides only limited biometric information. Here, an implantable multi-modal sensor array that can be injected through a small hole in the skull and inherently spread out for conformal contact with the cortical surface is reported. The injectable sensor array, composed of graphene multi-channel electrodes for neural recording and electrical stimulation and MoS₂-based sensors for monitoring intracranial temperature and pressure, is designed based on a mesh structure whose elastic restoring force enables the contracted device to spread out. It is demonstrated that the sensor array injected into a rabbit's head can detect epileptic discharges on the surface of the cortex and mitigate it by electrical stimulation while monitoring both intracranial temperature and pressure. This method provides good potential for implanting a variety of functional devices via minimally invasive surgery.

中文翻译：

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用于微创神经植入的可注射二维材料传感器阵列


用于诊断和治疗脑部疾病的颅内植入物在过去几十年里得到了发展。然而，传统植入设备的平台仍然依赖侵入式探头和笨重的传感器以及大面积开颅手术，并且仅提供有限的生物识别信息。在这里，报道了一种可植入的多模式传感器阵列，它可以通过头骨上的小孔注射，并固有地展开以与皮质表面保形接触。可注射传感器阵列由用于神经记录和电刺激的石墨烯多通道电极和用于监测颅内温度和压力的MoS ₂ 基传感器组成，基于网状结构设计，其弹性恢复力使得收缩装置展开。研究表明，注入兔子头部的传感器阵列可以检测皮质表面的癫痫放电，并通过电刺激减轻癫痫放电，同时监测颅内温度和压力。这种方法为通过微创手术植入各种功能装置提供了良好的潜力。