Associations of Ambient Particulate Matter with Maternal Thyroid Autoimmunity and Thyroid Function in Early Pregnancy,Environmental Science & Technology

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Associations of Ambient Particulate Matter with Maternal Thyroid Autoimmunity and Thyroid Function in Early Pregnancy
Environmental Science & Technology ( IF 11.4 ) Pub Date : 2024-05-14 , DOI: 10.1021/acs.est.3c10191
Enjie Zhang ₁ , Zheng Zhang ₁ , Gongbo Chen ₂ , Yun-Ting Zhang ₃ , Shaofei Su ₁ , Shen Gao ₁ , Shuanghua Xie ₁ , Jianhui Liu ₁ , Yue Zhang ₄ , Wentao Yue ₄ , Qingqing Wu ₅ , Yi Chen ₆ , Bo-Yi Yang ₃ , Yuming Guo ₇ , Ruixia Liu ₁ , Guang-Hui Dong ₃ , Chenghong Yin ₁

Affiliation

Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing 100026, China
Climate, Air Quality Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne VIC 3004, Australia
Guangdong Provincial Engineering Technology Research Center of Environmental and Health risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China
Department of Research Management, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing 100026, China
Department of Ultrasound, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital. Beijing 100026, China
Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing 100026, China
Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne VIC 3004, Australia

This prospective birth cohort study evaluated the association of exposure to PM_2.5 (diameter ≤2.5 μm), PM_1–2.5 (1–2.5 μm), and PM₁ (≤1 μm) with maternal thyroid autoimmunity and function during early pregnancy. A total of 15,664 pregnant women were included at 6 to 13⁺⁶ gestation weeks in China from 2018 to 2020. Single-pollutant models using generalized linear models (GLMs) showed that each 10 μg/m³ increase in PM_2.5 and PM_1–2.5 was related with 6% (odds ratio [OR] = 1.06, 95% confidence interval [CI]: 1.01, 1.12) and 15% (OR = 1.15, 95% CI: 1.08, 1.22) increases in the risk of thyroid autoimmunity, respectively. The odds of thyroid autoimmunity significantly increased with each interquartile range increase in PM_2.5 and PM_1–2.5 exposure (P for trend <0.001). PM₁ exposure was not significantly associated with thyroid autoimmunity. GLM with natural cubic splines demonstrated that increases in PM_2.5 and PM_1–2.5 exposure were associated with lower maternal FT4 levels, while a negative association between PM₁ and FT4 levels was found when exposure exceeded 32.13 μg/m³. Only PM_2.5 exposure was positively associated with thyrotropin (TSH) levels. Our findings suggest that high PM exposure is associated with maternal thyroid disruption during the early pregnancy.

更新日期：2024-05-14

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