A convenient method for the synthesis of perdeuterated alkyl amides/amines is disclosed. Perdeuterated acetyl amides can be achieved by a hydrogen–deuterium (H/D) exchange protocol with Pt/C as a catalyst and D₂O as a deuterium source under mild conditions. After removal or reduction of the acetyl group, this protocol can provide perdeuterated primary, secondary, and tertiary amines, which are difficult to achieve via other methods.

中文翻译：

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Pt/C催化温和条件下合成全氘代烷基胺/酰胺

公开了合成全氘代烷基酰胺/胺的简便方法。全氘化乙酰酰胺可以在温和条件下通过氢-氘（H/D）交换方案以Pt/C作为催化剂和D ₂ O作为氘源来获得。去除或还原乙酰基后，该方案可以提供全氘化的伯胺、仲胺和叔胺，这是其他方法难以实现的。