The Framingham Heart Study is an ongoing observational cohort study to identify risk factors for cardiovascular disease. Xavier and colleagues used data from study participants to investigate links between the gut microbiome and cardiovascular disease. They generated stool metagenomic and metabolomic data from 1,429 study participants. In particular, they identified that Oscillibacter species were associated with decreased faecal and plasma cholesterol. In vitro experiments identified that Oscillibacter isolates from the human gut encode conserved cholesterol-metabolizing enzymes, deepening our understanding of how the gut microbiome and its metabolites affect cardiovascular health.

弗雷明汉心脏研究是一项正在进行的观察性队列研究，旨在确定心血管疾病的危险因素。泽维尔和同事利用研究参与者的数据来调查肠道微生物组与心血管疾病之间的联系。他们从 1,429 名研究参与者中生成了粪便宏基因组和代谢组数据。特别是，他们发现振荡杆菌属与粪便和血浆胆固醇降低有关。体外实验发现，从人类肠道中分离出来的振荡杆菌编码保守的胆固醇代谢酶，加深了我们对肠道微生物组及其代谢物如何影响心血管健康的理解。