The flourishing progress in nanotechnology offers boundless opportunities for agriculture, particularly in the realm of nanopesticides research and development. However, concerns have been raised regarding the human and environmental safety issues stemming from the unrestrained use of non-therapeutic nanomaterials in nanopesticides. It is also important to consider whether the current development strategy of nanopesticides based on nanocarriers can strike a balance between investment and return, and if the complex material composition genuinely improves the efficiency, safety, and circularity of nanopesticides. Herein, we introduced the concept of nanopesticides with minimizing carriers (NMC) prepared through prodrug design and molecular self-assembly emerging as practical tools to address the current limitations, and compared it with nanopesticides employing non-therapeutic nanomaterials as carriers (NNC). We further summarized the current development strategy of NMC and examined potential challenges in its preparation, performance, and production. Overall, we asserted that the development of NMC systems can serve as the innovative driving force catalyzing a green and efficient revolution in nanopesticides, offering a way out of the current predicament.

纳米技术的蓬勃发展为农业提供了无限的机遇，特别是在纳米农药的研究和开发领域。然而，由于纳米农药中非治疗性纳米材料的无限制使用而引发的人类和环境安全问题引起了人们的担忧。同样重要的是要考虑目前基于纳米载体的纳米农药的发展策略是否能够在投资和回报之间取得平衡，以及复杂的材料成分是否真正提高了纳米农药的效率、安全性和循环性。在此，我们介绍了通过前药设计和分子自组装制备的最小化载体纳米农药（NMC）的概念，作为解决当前局限性的实用工具，并将其与采用非治疗性纳米材料作为载体的纳米农药（NNC）进行了比较。我们进一步总结了NMC当前的发展策略，并探讨了其制备、性能和生产方面的潜在挑战。总体而言，我们认为，纳米农药系统的发展可以成为催化纳米农药绿色高效革命的创新驱动力，为摆脱当前困境提供出路。