Developing semiconductor substrates with superior stability and sensitivity is challenging in surface-enhanced Raman scattering (SERS) research. Here, a snowflake CuS@ZIF-67 heterostructure was fabricated using a straightforward method, exhibiting a notable enhancement factor of 9.0 × 10 and a limit of detection (LOD) of 10 M for methylene blue (MB). In addition, the CuS@ZIF-67 heterostructure substrate demonstrates outstanding homogeneity (relative standard deviation (RSD) = 9.2%) and stability (120 days). Employing CuS generates highly sensitive hotspots via an electromagnetic (EM) mechanism, and the growth of ZIF-67 on its surface augments the adsorption capacity and charge transfer capability (chemical mechanism, CM), thereby enhancing the SERS detection sensitivity. Furthermore, the CuS@ZIF-67 heterostructure, which was used as a SERS substrate, facilitated the detection of bisphenol A (BPA) with an LOD of 10 M. The CuS@ZIF-67 heterostructure substrate has excellent selectivity and anti-interference, which is very suitable for BPA detection in complex environment applications. The accuracy of the CuS@ZIF-67 heterostructure as a SERS substrate for detecting BPA in real water samples (water bottles, tap water, and pure milk) was confirmed by comparison with high-performance liquid chromatography (HPLC). These results demonstrate that through the rational design of heterostructures can achieve the quantitative and accurate detection of hazardous substances in food and the environment can be achieved.

中文翻译：

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Snowflake Cu2S@ZIF-67：一种新型异质结构基板，用于增强 BPA 中的吸附和灵敏检测


在表面增强拉曼散射 (SERS) 研究中，开发具有卓越稳定性和灵敏度的半导体衬底具有挑战性。在这里，使用简单的方法制备了雪花 CuS@ZIF-67 异质结构，表现出 9.0 × 10 的显着增强因子和亚甲基蓝 (MB) 的 10 M 检测限 (LOD)。此外，CuS@ZIF-67 异质结构基板表现出出色的均匀性（相对标准偏差 (RSD) = 9.2%）和稳定性（120 天）。采用CuS通过电磁（EM）机制产生高灵敏度热点，ZIF-67在其表面的生长增强了吸附能力和电荷转移能力（化学机制，CM），从而提高了SERS检测灵敏度。此外，CuS@ZIF-67异质结构用作SERS底物，有助于检测LOD为10 M的双酚A（BPA）。CuS@ZIF-67异质结构底物具有优异的选择性和抗干扰性。非常适合复杂环境应用中的BPA检测。通过与高效液相色谱（HPLC）的比较，证实了 CuS@ZIF-67 异质结构作为 SERS 底物检测真实水样（水瓶、自来水和纯牛奶）中 BPA 的准确性。这些结果表明，通过异质结构的合理设计可以实现食品和环境中有害物质的定量和准确检测。