Brain-targeting drug delivery remains a massive challenge due to the complexity and delicacy of the human brain. However, it is of paramount importance because many neurological disorders, such as Alzheimer's disease, Parkinson's disease, and brain tumors, necessitate precise and targeted drug delivery to achieve optimal therapeutic outcomes while minimizing side effects. Metal-organic frameworks (MOFs) represent a remarkable fusion of inorganic and organic materials through diverse connection modes involving inorganic metal ions and organic bridging ligands, forming versatile pore structures. MOF-based nanomedicine has promising potential for targeted delivery of therapeutic agents thanks to their customizable nanostructures and functionalities. The regulated pores within MOFs offer an ideal platform for drug encapsulation. At the same time, the programmable framework environments present potential binding sites for targeted drug delivery to specific cells or lesion sites, particularly in delicate and sensitive organs such as the brain. This targeted approach is crucial to minimize adverse effects on healthy cells. Recent advances have witnessed the utilization of various MOFs combined with functional agents for drug loading, delivery, release, and process monitoring. In this study, we provide an overview of the roles played by MOFs in brain-targeted drug delivery and lay the foundation for the future development of advanced and precise administration strategies.

中文翻译：

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使用基于金属有机框架的纳米药物对大脑进行特异性靶向递送治疗剂

由于人脑的复杂性和脆弱性，脑靶向药物输送仍然是一个巨大的挑战。然而，它至关重要，因为许多神经系统疾病，如阿尔茨海默病、帕金森病和脑肿瘤，需要精确和有针对性的药物输送，以实现最佳治疗结果，同时最大限度地减少副作用。金属有机框架（MOF）代表了无机和有机材料通过涉及无机金属离子和有机桥配体的多种连接模式的显着融合，形成多功能的孔结构。基于 MOF 的纳米医学由于其可定制的纳米结构和功能，在治疗药物的靶向递送方面具有广阔的潜力。 MOF 内的调节孔为药物封装提供了理想的平台。同时，可编程框架环境提供了潜在的结合位点，用于将靶向药物输送到特定细胞或病变部位，特别是在大脑等脆弱而敏感的器官中。这种有针对性的方法对于最大限度地减少对健康细胞的不利影响至关重要。最近的进展见证了各种 MOF 与功能剂的结合用于药物装载、递送、释放和过程监控。在这项研究中，我们概述了MOFs在脑靶向药物递送中所发挥的作用，并为未来发展先进和精确的给药策略奠定了基础。