Inorganic–organic hybrid materials that combine both Polyoxometalates (POMs) and metal ion coordinating subunits (CSUs) represent promising multifunctional materials. Though their individual components are often biologically active, utilization of hybrid materials in bioassays significantly depends on the functionalization method and thus resulting stability of the system. Quite intriguingly, these aspects were very scarcely studied in hybrid materials based on the Wells–Dawson POM (WD POM) scaffold and remain unknown. We chose two model WD POM hybrid systems to establish how the functionalization mode (ionic vs. covalent) affects their stability in biological medium and interaction with nucleic acids. The synthetic scope and limitations of the covalent POM-terpyridine hybrids were demonstrated and compared with the ionic Complex-Decorated Surfactant Encapsulated-Clusters (CD-SECs) hybrids. The nature of POM and CSU binding can be utilized to modulate the stability of the hybrid and the extent of DNA binding. The above systems show potential to behave as model cargo-platforms for potential utilization in medicine and pharmacy.

中文翻译：

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具有配位亚基的多金属氧酸盐杂化材料的离子与共价功能化对其稳定性和与 DNA 相互作用的影响


结合了多金属氧酸盐（POM）和金属离子配位亚基（CSU）的无机-有机杂化材料代表了有前途的多功能材料。尽管它们的各个成分通常具有生物活性，但混合材料在生物测定中的利用很大程度上取决于功能化方法，从而导致系统的稳定性。非常有趣的是，在基于 Wells-Dawson POM (WD POM) 支架的混合材料中，这些方面的研究很少，并且仍然未知。我们选择了两种模型 WD POM 混合系统来确定功能化模式（离子与共价）如何影响它们在生物介质中的稳定性以及与核酸的相互作用。论证了共价 POM-三联吡啶杂化物的合成范围和局限性，并与离子络合物装饰的表面活性剂封装簇 (CD-SEC) 杂化物进行了比较。 POM 和 CSU 结合的性质可用于调节杂交体的稳定性和 DNA 结合的程度。上述系统显示出作为模型货物平台的潜力，可用于医学和制药领域。