The patient was a 36-year-old man, who had a 4-year history of ulcerative colitis (UC), for which he had received mesalazine, oral prednisolone and infliximab, neither of which had any long-lasting therapeutic benefit. This patient was admitted to our hospital with skin lesions, abdominal pain and diarrhoea. Two types of skin lesions were evident. First, one well-demarcated superficial ulcer, covered by yellow secretions and surrounded by a purple halo, was seen over the patient’s left knee region (figure 1A). Second, on the patient’s face (figure 1B) and trunk (figure 1C), there was a polymorphic rash consisting of open comedones, papules and some deeply set cysts, in association with numerous hyperpigmented scars. He was treated with minocycline 100 mg/day for …

中文翻译：

---

诊断困境：肠道疾病患者突然出现多处皮肤病变

该患者为一名36岁男性，有4年溃疡性结肠炎（UC）病史，曾接受美沙拉嗪、口服泼尼松龙和英夫利昔单抗治疗，但均未获得任何长期治疗效果。该患者因皮损、腹痛、腹泻入院。两种类型的皮肤损伤是明显的。首先，在患者的左膝区域看到一个界限清楚的浅表溃疡，上面覆盖着黄色分泌物，周围有紫色晕圈（图 1A）。其次，在患者的面部（图 1B）和躯干（图 1C）上，出现多形性皮疹，包括开放性粉刺、丘疹和一些深陷的囊肿，并伴有许多色素沉着过度的疤痕。他每天接受 100 毫克米诺环素治疗……