Arachidonic acid (AA), one of the most ubiquitous polyunsaturated fatty acids (PUFAs), provides fluidity to mammalian cell membranes. It is derived from linoleic acid (LA) and can be transformed into various bioactive metabolites, including prostaglandins (PGs), thromboxanes (TXs), lipoxins (LXs), hydroxy-eicosatetraenoic acids (HETEs), leukotrienes (LTs), and epoxyeicosatrienoic acids (EETs), by different pathways. All these processes are involved in AA metabolism. Currently, in the context of an increasingly visible aging world population, several scholars have revealed the essential role of AA metabolism in osteoporosis, chronic obstructive pulmonary disease, and many other aging diseases. Although there are some reviews describing the role of AA in some specific diseases, there seems to be no or little information on the role of AA metabolism in aging tissues or organs. This review scrutinizes and highlights the role of AA metabolism in aging and provides a new idea for strategies for treating aging-related diseases. As a member of lipid metabolism, AA metabolism regulates the important lipids that interfere with the aging in several ways. We present a comprehensivereviewofthe role ofAA metabolism in aging, with the aim of relieving the extreme suffering of families and the heavy economic burden on society caused by age-related diseases. We also collected and summarized data on anti-aging therapies associated with AA metabolism, with the expectation of identifying a novel and efficient way to protect against aging.

中文翻译：

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花生四烯酸在衰老中的作用：老玩家的新角色


花生四烯酸 (AA) 是最普遍的多不饱和脂肪酸 (PUFA) 之一，为哺乳动物细胞膜提供流动性。它源自亚油酸（LA），可转化为各种生物活性代谢物，包括前列腺素（PG）、血栓素（TX）、脂氧素（LX）、羟基二十碳四烯酸（HETE）、白三烯（LT）和环氧二十碳三烯酸（EET），通过不同的途径。所有这些过程都参与AA代谢。目前，在世界人口老龄化日益明显的背景下，一些学者揭示了AA代谢在骨质疏松、慢性阻塞性肺疾病和许多其他衰老疾病中的重要作用。尽管有一些评论描述了 AA 在某些特定疾病中的作用，但似乎没有或很少有关于 AA 代谢在衰老组织或器官中的作用的信息。这篇综述仔细研究并强调了 AA 代谢在衰老中的作用，并为治疗衰老相关疾病的策略提供了新思路。作为脂质代谢的一员，AA代谢通过多种方式调节干扰衰老的重要脂质。我们对AA代谢在衰老中的作用进行了全面的综述，旨在减轻与年龄相关的疾病给家庭带来的极度痛苦和给社会带来的沉重经济负担。我们还收集并总结了与 AA 代谢相关的抗衰老疗法的数据，期望找到一种新颖有效的方法来预防衰老。