AimTo investigate the bidirectional influence between periodontitis and psoriasis, using the respective experimental models of ligature‐ and imiquimod‐induced diseases on murine models.Materials and MethodsThirty‐two C57/BL6J mice were randomly allocated to four experimental groups: control (P− Pso−), ligature‐induced periodontitis (P+ Pso−), imiquimod‐induced psoriasis (P− Pso+) and periodontitis and psoriasis (P+ Pso+). Samples (maxilla, dorsal skin and blood) were harvested immediately after death. Measures of periodontitis (distance between the cemento‐enamel junction and alveolar bone crest [CEJ–ABC] and the number of osteoclasts) and psoriasis (epidermal thickness and infiltrate cell [/0.03mm2]) severity as well as systemic inflammation (IL‐6, IL‐17A, TNF‐α) were collected.ResultsThe P+ Pso+ group exhibited the most severe experimental periodontitis and psoriasis, with the highest values of CEJ–ABC, number of osteoclasts, epidermal thickness and infiltrate cells in the dorsal skin, as well as the highest blood cytokine concentration. The P+ Pso− group presented with higher cell infiltrate (/0.03mm2) compared to the control group (p <.05), while the P− Pso+ group showed substantially higher alveolar bone loss (CEJ–ABC) than the control group (p <.05).ConclusionsExperimental periodontitis may initiate and maintain psoriasiform skin inflammation and, vice versa, experimental psoriasis may contribute to the onset of periodontitis. In a combined model of the diseases, we propose a bidirectional association between periodontitis and psoriasis via systemic inflammation.

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牙周炎和牛皮癣有关联吗？临床前小鼠模型

目的 利用结扎和咪喹莫特诱发疾病的小鼠模型，探讨牙周炎和银屑病之间的双向影响。 材料与方法 将 32 只 C57/BL6J 小鼠随机分为 4 个实验组：对照组（P− Pso− ）、结扎诱发的牙周炎（P+ Pso−）、咪喹莫特诱发的银屑病（P− Pso+）以及牙周炎和银屑病（P+ Pso+）。死亡后立即采集样本（上颌骨、背部皮肤和血液）。牙周炎（牙骨质连接处和牙槽骨嵴之间的距离[CEJ-ABC]和破骨细胞数量）和银屑病（表皮厚度和浸润细胞[/0.03mm]2]）收集了严重程度以及全身炎症（IL-6、IL-17A、TNF-α）。 结果 P+ Pso+ 组表现出最严重的实验性牙周炎和银屑病，CEJ-ABC、破骨细胞数量、表皮厚度和背部皮肤浸润细胞，以及最高的血液细胞因子浓度。 P+ Pso− 组呈现出更高的细胞浸润（/0.03mm2）与对照组（p<.05)，而 P− Pso+ 组的牙槽骨丢失 (CEJ-ABC) 明显高于对照组（p<.05).结论实验性牙周炎可能引发并维持银屑病样皮肤炎症，反之亦然，实验性银屑病可能导致牙周炎的发生。在疾病的组合模型中，我们提出牙周炎和银屑病之间通过全身炎症存在双向关联。