In the pharmaceutical and fine chemical industries, spherical particles are highly valuable due to their numerous applications; however, they are hindered by traditional methods requiring intricate devices, high energy consumption, and biohazardous solvents. In this study, we constructed a strategy for the design of spherical particles based on thermal-induced liquid–liquid phase separation at the microscopic molecular level. Based on this strategy, high-performance spherical particles were successfully prepared in water by a simple heating-quenching operation. Moreover, this strategy could also control the solid structure of particles by utilizing intermolecular interactions to meet the requirements of various application scenarios. In the case of fenofibrate, the equipment was simplified, the use of organic solvents was avoided, and the powder properties, filtration properties, and tableting performance of the product were significantly enhanced compared to those reported literature. This work elucidated the design and green production of new crystalline/amorphous materials with versatile functions.

中文翻译：

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热诱导液-液相分离水中球形颗粒的设计与制备及分子机理研究


在医药和精细化工行业，球形颗粒因其用途广泛而具有很高的价值；然而，它们受到需要复杂设备、高能耗和生物危害溶剂的传统方法的阻碍。在这项研究中，我们构建了一种基于微观分子水平上的热诱导液-液相分离的球形颗粒设计策略。基于该策略，通过简单的加热淬火操作在水中成功制备了高性能球形颗粒。此外，该策略还可以利用分子间相互作用来控制颗粒的固体结构，以满足各种应用场景的要求。以非诺贝特为例，简化了设备，避免了有机溶剂的使用，产品的粉末性能、过滤性能和压片性能较文献报道显着增强。这项工作阐明了具有多功能的新型晶体/非晶材料的设计和绿色生产。