BackgroundOffspring of parents with affective disorders (OAD) are at risk of developing a wide range of mental disorders. Deficits in the rearing environment and high levels of stress are well‐known risk factors for negative outcomes in OAD. Building on prior research, we aim to examine the longitudinal relationships between family dysfunction, stressful life events, and mental health in OAD and control offspring of parents with no affective disorder. In the present study, we hypothesized that high levels of family dysfunction would be associated with more internalizing and externalizing problems across time in OAD than in controls, and that family dysfunction would mediate the relationship between stressful life events in adolescence and poor mental health in adulthood, particularly in OAD.MethodsAs part of the TRacking Adolescents' Lives Survey (TRAILS), 2230 participants (51% female, Mage = 11.1 years, SD = 0.6, at baseline) and their parents completed measures across six time points, spanning 15 years. Mental health, family dysfunction, and stressful life events were assessed with the Youth and Adult Self‐Report, Family Assessment Device, and an in‐house measure, respectively.ResultsMulti‐group structured equation modeling revealed that family dysfunction was linked to internalizing and externalizing problems in OAD, but not controls, across time. Risk status did not moderate family dysfunction's mediation of the relationship between stressful life events and negative outcomes in adulthood.ConclusionsOAD show high sensitivity to dysfunction in the rearing environment across childhood and adolescence, which supports the use of family based interventions to prevent the development of mental disorders in high‐risk youth.

中文翻译：

---

患有情感障碍的父母的后代的家庭功能障碍、压力性生活事件以及整个发育过程中的心理健康问题

背景 患有情感障碍（OAD）的父母的后代有患上多种精神障碍的风险。饲养环境缺陷和高压力是众所周知的 OAD 不良结果的危险因素。在先前研究的基础上，我们的目标是研究 OAD 中家庭功能障碍、压力生活事件和心理健康之间的纵向关系，并对照没有情感障碍的父母的后代。在本研究中，我们假设，与对照组相比，在 OAD 中，高水平的家庭功能障碍与不同时间段内更多的内化和外化问题相关，并且家庭功能障碍会介导青春期压力生活事件与成年期不良心理健康之间的关系。 ，特别是在 OAD 中。方法作为跟踪青少年生活调查 (TRAILS) 的一部分，有 2230 名参与者（51% 为女性，中号年龄= 11.1 年，标清= 0.6，基线），他们的父母在 15 年的六个时间点完成了测量。心理健康、家庭功能障碍和压力生活事件均通过青少年和成人自我报告,家庭评估装置结果多组结构化方程模型显示，随着时间的推移，家庭功能障碍与 OAD 的内化和外化问题有关，但与对照组无关。风险状态并不能调节家庭功能障碍对压力生活事件与成年期负面结果之间关系的调节。结论OAD 对儿童期和青春期的养育环境功能障碍表现出高度敏感性，这支持使用基于家庭的干预措施来预防心理发展。高危青少年的疾病。