Somatostatin vs. Octreotide for Prevention of Postoperative Pancreatic Fistula The PREFIPS Randomized Clinical Trial A FRENCH 007 - ACHBT Study.,Annals of Surgery

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Somatostatin vs. Octreotide for Prevention of Postoperative Pancreatic Fistula The PREFIPS Randomized Clinical Trial A FRENCH 007 - ACHBT Study.
Annals of Surgery ( IF 9 ) Pub Date : 2024-04-25 , DOI: 10.1097/sla.0000000000006313
Sébastien Gaujoux _{1,

2} , Jean-Marc Regimbeau _{3,

4} , Guillaume Piessen _{5,

6} , Stéphanie Truant _{6,

7} , Frantz Foissac ₈ , Louise Barbier _{9,

10} , Emmanuel Buc _{11,

12} , Mustapha Adham _{13,

14} , David Fuks _{15,

16} , Sophie Deguelte _{17,

18} , Fabrice Muscari _{19,

20} , Laurent Sulpice _{21,

22} , Jean-Christophe Vaillant _{1,

2} , Lilian Schwarz _{23,

24} , Antonio Sa Cunha _{25,

26} , Milena Muzzolini _{1,

2} , Bertrand Dousset _{15,

16} , Alain Sauvanet _{27,

28}

Affiliation

Department of Hepatobiliary and Pancreatic Surgery and Liver Transplantation, AP-HP Pitié-Salpêtrière Hospital, Paris
Sorbonne University, Paris, France
Department of Oncology and Digestive Surgery, CHU Amiens-Picardie, Amiens, France
University of Picardie Jules-Vernes, Amiens, France
CHU Lille, Department of Digestive and Oncological Surgery, F-59000 Lille, France
Univ. Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277 - CANTHER – Cancer Heterogeneity Plasticity and Resistance to Therapies, F-59000 Lille, France
Department of Digestive Surgery and Transplantation, CHU Lille, Lille, France
Clinical Research Unit Necker Cochin Hospital, APHP, France
Department of digestive Surgery and liver transplantation, CHU Tours Trousseau, Tours, France
University of Tours, Tours, France
Department of Digestive and Hepatobiliary Surgery, Estaing Hospital, CHU Clermont-Ferrand, Clermont-Ferrand, France
Clermont-Ferrand Faculty of Medicine, Clermont-Ferrand, France
Digestive Surgery Unit, Edouard Herriot Hospital, Lyon, France
Hospices Civils of Lyon University, Lyon, France
Department of Digestive, Pancreatic, Hepatobiliary and Endocrine Surgery, Cochin Hospital, APHP, Paris, France
University of Paris, Paris, France
Digestive Surgery Department, Reims University Hospital, Robert Debré hospital, Reims, France
Reims University Hospital, Robert Debré hospital, Reims, France
Digestive Surgery and Liver Transplantation Department, Toulouse University Hospital, Toulouse, France
Toulouse University, Toulouse, France
Department of Hepatobiliary and Digestive Surgery hospital Rennes, Rennes, France
Rennes University, Rennes, France
Department of Digestive Surgery, Charles Nicolle Hospital, Rouen, France
Rouen University, Rouen, France
Department of Hepatobiliary Surgery and Liver Transplantation, Paul Brousse Hospital, Villejuif, France
University Paris-Saclay, Saclay, France
Department of Hepatobiliary Surgery, Beaujon Hospital, Clichy, France
University Paris Cité, Paris, France

Pharmacological prevention of postoperative pancreatic fistula (POPF) after pancreatectomy is open to debate. The present study compares clinically significant POPF rates in patients randomized between somatostatin versus octreotide as prophylactic treatment.

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