Extract

We read with interest the recent original research investigation by Valencia-Hernández et al. [1]. This observational study used two approaches to investigate the association of asthma and coronary heart disease (CHD): medical records and Mendelian randomisation (MR). Their results differ compared to many other prior studies investigating the association of asthma and CHD [2]. We applaud the authors for the thoroughness of the investigation; however, we have identified key methodological considerations in this study which may account for differences in the conclusions, compared to prior studies.

中文翻译：

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哮喘和心血管疾病：需要接受疾病异质性

提炼

我们饶有兴趣地阅读了 V 最近的原创研究调查阿伦西亚-H埃尔南德斯 等人。 [1]。这项观察性研究使用两种方法来调查哮喘与冠心病 (CHD) 的关联：医疗记录和孟德尔随机化 (MR)。他们的结果与许多其他先前调查哮喘和冠心病关联的研究不同[2]。我们对作者的彻底调查表示赞赏；然而，我们在这项研究中确定了关键的方法学考虑因素，这可能是与之前的研究相比结论存在差异的原因。