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FLT3 agonists and secondary hematopoietic malignancies: a potential class effect
Clinical Cancer Research ( IF 11.5 ) Pub Date : 2024-04-23 , DOI: 10.1158/1078-0432.ccr-24-0460
Henry W. Raeder 1 , Michael W. Drazer 2
Affiliation  

Expansion of cDC cells via FLT3 agonism has promising therapeutic potential in the treatment of advanced solid tumors. Here, we discuss the results of a clinical trial using GS-3583, an FLT3 agonist, that was stopped after a patient in the study developed acute myeloid leukemia.

中文翻译:

FLT3 激动剂和继发性造血系统恶性肿瘤:潜在的类别效应

通过FLT3激动剂扩增cDC细胞在治疗晚期实体瘤方面具有广阔的治疗潜力。在这里,我们讨论使用 GS-3583(一种 FLT3 激动剂)的临床试验的结果,该试验在研究中的一名患者患上急性髓系白血病后停止。
更新日期:2024-04-23
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