Effects of Tirofiban on Neurological Deterioration in Patients With Acute Ischemic Stroke: A Randomized Clinical Trial.,JAMA Neurology

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Effects of Tirofiban on Neurological Deterioration in Patients With Acute Ischemic Stroke: A Randomized Clinical Trial.
JAMA Neurology ( IF 29.0 ) Pub Date : 2024-04-22 , DOI: 10.1001/jamaneurol.2024.0868
Wenbo Zhao ₁ , Sijie Li _{1,

2,

3} , Chuanhui Li ₄ , Chuanjie Wu ₁ , Junmei Wang ₅ , Lifei Xing ₆ , Yue Wan ₇ , Jinhui Qin ₈ , Yaoming Xu _{9,

10} , Ruixian Wang _{11,

12} , Changming Wen ₁₃ , Aihua Wang ₁₄ , Lan Liu ₁₅ , Jing Wang ₁ , Haiqing Song ₁ , Wuwei Feng ₁₆ , Qingfeng Ma ₁ , Xunming Ji ₁₇ , Jianping Ding ₁₈ , Pingping Wang ₁₈ , Yuan Wang ₁₈ , Xiaojun Hao ₁₈ , Bujv Bian ₁₈ , Guanqing Feng ₁₈ , Yujia Xie ₁₈ , Hui Wen ₁₈ , Xinlin Yang ₁₈ , Wenzhao Li ₁₈ , Yuejiang Gui ₁₈ , Jing Hao ₁₈ , Yaqiong Zhang ₁₈ , Qing Zhao ₁₈ , Yang Yang ₁₈ , Rutao Liu ₁₈ , Shanchao Zhang ₁₈ , Zhihui Si ₁₈ , Shan Qiao ₁₈ , Shan Xu ₁₈ , Jing Yuan ₁₈ , Yajuan Shao ₁₈ , Fang Dai ₁₈ , Guofeng Zhang ₁₈ , Yanchao Huo ₁₈ , Wenjing Zhou ₁₈ , Lu Yang ₁₈ , Xufei Cheng ₁₈ , Min Wang ₁₈ , Haidong Hou ₁₈ , Haiying Wang ₁₈ , Hongliang Yan ₁₈ , Yajuan Fu ₁₈ , Bowen Zang ₁₈ , Meiping Zhao ₁₈ , Pingping Wen ₁₈ , Jianying Lv ₁₈ , Xiaojing Lian ₁₈ , Meijuan Kang ₁₈ , Zaihang Zhang ₁₈ , Qing Zhang ₁₈ , Zaiyu Guo ₁₈ , Lianhua Zhao ₁₈ , Xiaoliang Liu ₁₈ , Jing Zheng ₁₈ , Shangsheng Ke ₁₈ , Lin Shao ₁₈ , Xiaoyan Liu ₁₈ , Xiaoming Tao ₁₈ , Yingbing Ke ₁₈ , Hao Liu ₁₈ , Dandan He ₁₈ ,

Affiliation

Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China
Department of Emergency, Xuanwu Hospital, Capital Medical University, Beijing, China
Beijing Key Laboratory of Hypoxic Conditioning Translational Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China
Stroke Center, Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China
Department of Neurology, Ordos Central Hospital, Ordos, Inner Mongolia, China
Department of Neurology, Sinopharm North Hospital, Baotou, Inner Mongolia, China
Department of Neurology, The Third People’s Hospital of Hubei Province, Wuhan, Hubei, China
Department of Neurology, Nanyang Second People’s Hospital, Nanyang, Henan, China
Department of Neurology, Tongliao City Hospital, Tongliao, Inner Mongolia, China
Department of Neurology, Affiliated Hospital of Inner Mongolia Minzu University, Inner Mongolia, China
Department of Neurology, Traditional Chinese Medicine Hospital of Tianjin Beichen District, Tianjin, China
Department of Neurology, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin, China
Department of Neurology, Nanyang Central Hospital, Nanyang, Henan, China
Department of Neurology, Qianfo Mountain Hospital of Shandong University, Jinan, China
School of Statistics, University of Minnesota at Twin Cities, Minneapolis
Department of Neurology, Duke University School of Medicine, Durham, North Carolina
Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China
for the TREND Investigators

Evidence supports using antiplatelet therapy in patients with acute ischemic stroke. However, neurological deterioration remains common under the currently recommended antiplatelet regimen, leading to poor clinical outcomes.

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