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Copper-Promoted Oxidative Amidation of Imines: A Facile Route to Amides
European Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2024-04-20 , DOI: 10.1002/ejoc.202400315
Zhonghua Cao 1 , Da Sheng 1 , Zhiyang Zhang 1 , Haitao Ren 2 , Yong Liu 3 , Songhai Wu 1 , Jiaxiang Zhang 1 , Xu Han 4
Affiliation  

A method for preparing amides by imines oxidation is developed using aldehydes and amines as raw materials. Using copper oxide as catalyst and Oxone as oxidant without any coupling reagents, the reaction conditions are mild. A wide substrate range including pesticide and drug molecules has been demonstrated in 32–90 % yields.

中文翻译:


铜促进的亚胺氧化酰胺化:一种简便的酰胺化途径



开发了一种以醛和胺为原料,亚胺氧化制备酰胺的方法。以氧化铜为催化剂,Oxone为氧化剂,不使用任何偶联剂,反应条件温和。包括农药和药物分子在内的多种底物已被证明具有 32-90% 的产率。
更新日期:2024-04-20
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