A Palladium-catalyzed C−H acyloxylation of azobenzenes enabling the regioselective introduction of the double-functionalized phophonoacetate motif was developed. The method proved tolerant for a wide range of substituents. Chemoselective hydrolysis of the diethylphosphonate function leads to a water-soluble azobenzene with interesting photophysical properties, holding great promise for the design of water-soluble photochemical tools for future biological applications.

中文翻译：

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钯催化偶氮苯的间接和区域选择性膦化：水溶性光开关的设计


开发了一种钯催化的偶氮苯 C−H 酰氧基化反应，能够区域选择性地引入双功能化膦酰乙酸基序。事实证明，该方法可以耐受多种取代基。二乙基膦酸酯官能团的化学选择性水解产生了具有有趣的光物理性质的水溶性偶氮苯，这为未来生物应用的水溶性光化学工具的设计带来了巨大的希望。