We present the design and synthesis of two novel noncoded α-amino acids, incorporating a lysine-engaging salicylaldehyde tag on the side chain. These key building blocks open to the versatile positioning of the electrophile tag within peptide sequences, enabling tailored design of reversible-covalent peptide binders for clinically-relevant proteins.

中文翻译：

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带有水杨醛标签的非编码氨基酸的合成用于可逆共价肽的设计


我们提出了两种新型非编码 α-氨基酸的设计和合成，在侧链上结合了赖氨酸接合水杨醛标签。这些关键构建模块可以实现肽序列中亲电子标签的多功能定位，从而能够为临床相关蛋白质定制设计可逆共价肽结合物。