There are limited data on the causative agents and characteristics of drug-induced liver injury in pregnant individuals. Data from patients with drug-induced liver injury enrolled in the ongoing multicenter Drug-Induced Liver Injury Network between 2004 and 2022 and occurring during pregnancy or 6 months postpartum were reviewed and compared with cases of drug-induced liver injury in nonpregnant women of childbearing age. Among 325 individuals of childbearing age in the Drug-Induced Liver Injury Network, 16 cases of drug-induced liver injury (5%) occurred during pregnancy or postpartum. Compared with drug-induced liver injury in nonpregnant women, pregnancy-related drug-induced liver injury was more severe (P<.05). One elective termination and three miscarriages were documented; there were no maternal deaths. We recommend that isoniazid for latent tuberculosis be deferred to the postpartum period whenever feasible and that β-blockers or calcium channel blockers rather than methyldopa be used for hypertension management during pregnancy.

中文翻译：

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妊娠期药物性肝损伤：美国药物性肝损伤网络经验。

关于妊娠个体药物性肝损伤的病原体和特征的数据有限。对 2004 年至 2022 年间纳入正在进行的多中心药物性肝损伤网络且发生在妊娠期间或产后 6 个月的药物性肝损伤患者的数据进行了审查，并与非妊娠育龄妇女的药物性肝损伤病例进行了比较。在药物性肝损伤网络的325名育龄个体中，16例（5%）发生在妊娠期或产后。与非妊娠女性药物性肝损伤相比，妊娠相关药物性肝损伤更为严重（P<.05）。记录有 1 例选择性终止妊娠和 3 例流产；没有孕产妇死亡。我们建议，在可行的情况下，将异烟肼治疗潜伏性结核病推迟到产后，并使用β受体阻滞剂或钙通道阻滞剂而不是甲基多巴来治疗妊娠期间的高血压。