Lovastatin and its derivatives are well-known as a class of lipid-lowering drugs in the medicinal chemistry of natural products, and they typically feature a rigid decalin core structure with almost no other carbon rings. Herein, aculeatones A (1) and B (2), two highly modified lovastatin derivatives with an unreported 6/6/3-tricyclic carbon skeleton, in addition to four undescribed lovastatin derivatives aculeatones C–F (3–6), were isolated from the fungus Aspergillus aculeatus. Their structures with absolute configurations were characterized by comprehensive spectroscopic, quantum chemical calculation, electronic circular dichroism (ECD), modified Mosher's method, and single-crystal X-ray diffraction studies. The plausible biosynthetic pathway for 1 and 2 was proposed, and the biomimetic formation of 1 was achieved starting from 3. Biologically, compounds 3, 5, and 6 significantly inhibited the accumulation of lipid in an oleic acid-treated HepG2 cell model.

中文翻译：

---

Aculeatones A 和 B，来自棘孢曲霉的具有 6/6/3-三环碳骨架的差向异构洛伐他汀衍生物及其化学转化

洛伐他汀及其衍生物是天然产物药物化学中众所周知的一类降脂药物，它们通常具有刚性的十氢萘核心结构，几乎没有其他碳环。在此，分离出两种高度修饰的具有未报道的 6/6/3-三环碳骨架的洛伐他汀衍生物aculeatones A ( 1 ) 和 B ( 2 )，以及四种未描述的洛伐他汀衍生物 aculeatones C–F ( 3–6 )。来自真菌棘孢曲霉。通过综合光谱、量子化学计算、电子圆二色性（ECD）、改进的Mosher方法和单晶X射线衍射研究对它们的绝对构型结构进行了表征。提出了1和2的合理生物合成途径，并从3开始仿生形成1。从生物学角度来看，化合物3、5和6显着抑制油酸处理的 HepG2 细胞模型中的脂质积累。