A GITRL-mTORC1-GM-CSF Positive Loop Promotes Pathogenic Th17 Response in Primary Sjögren Syndrome,Arthritis & Rheumatology

当前位置： X-MOL 学术 › Arthritis Rheumatol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

A GITRL-mTORC1-GM-CSF Positive Loop Promotes Pathogenic Th17 Response in Primary Sjögren Syndrome
Arthritis & Rheumatology ( IF 13.3 ) Pub Date : 2024-04-08 , DOI: 10.1002/art.42859
Yuzhou Gan _{1,

2} , Haotian Zhou _{1,

2} , Yixue Guo _{1,

2} , Bo Huang _{1,

2} , Hongjiang Liu _{1,

2} , Ziye Wang _{1,

2} , Zijun Li _{1,

2} , Xiaozhen Zhao _{1,

2} , Huaqun Zhu _{1,

2} , Qimao Han ₃ , Hua Ye _{1,

2} , Jing He _{1,

2} , Qingwen Wang ₄ , Zhanguo Li _{1,

2} , Xiaolin Sun _{1,

2}

Affiliation

Glucocorticoid-induced tumor necrosis factor receptor superfamily–related protein (GITR), with its ligand (GITRL), plays an important role in CD4⁺ T cell–mediated autoimmunity. This study aimed to investigate the underlying mechanisms of GITRL in primary Sjögren syndrome (pSS).

中文翻译：

GITRL-mTORC1-GM-CSF 正环促进原发性干燥综合征的致病性 Th17 反应

糖皮质激素诱导的肿瘤坏死因子受体超家族相关蛋白（GITR）及其配体（GITRL）在CD4 ⁺ T细胞介导的自身免疫中发挥重要作用。本研究旨在探讨 GITRL 在原发性干燥综合征 (pSS) 中的潜在机制。

更新日期：2024-04-08

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南

全部期刊列表>>