Summary: Research on precancers, as defined as at-risk tissues and early lesions, is of high significance given the effectiveness of early intervention. We discuss the need for risk stratification to prevent overtreatment, an emphasis on the role of genetic and epigenetic aging when considering risk, and the importance of integrating macroenvironmental risk factors with molecules and cells in lesions and at-risk normal tissues for developing effective intervention and health policy strategies.

中文翻译：

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癌前病变的标志

摘要：鉴于早期干预的有效性，对癌前病变（定义为高危组织和早期病变）的研究具有重要意义。我们讨论了风险分层的必要性，以防止过度治疗，在考虑风险时强调遗传和表观遗传衰老的作用，以及将宏观环境风险因素与病变和高危正常组织中的分子和细胞相结合以制定有效的干预措施和治疗的重要性。卫生政策战略。