Glioblastoma (GBM) is the most common malignant tumour of the central nervous system. Despite recent advances in multimodal GBM therapy incorporating surgery, radiotherapy, systemic therapy (chemotherapy, targeted therapy), and supportive care, the overall survival (OS) remains poor, and long-term survival is rare. Currently, the primary obstacles hindering the effectiveness of GBM treatment are still the blood-brain barrier and tumor heterogeneity. In light of its substantial advantages over conventional therapies, such as strong penetrative ability and minimal side effects, low-frequency magnetic fields (LF-MFs) therapy has gradually caught the attention of scientists. In this review, we shed the light on the current status of applying LF-MFs in the treatment of GBM. We specifically emphasize our current understanding of the mechanisms by which LF-MFs mediate anticancer effects and the challenges faced by LF-MFs in treating GBM cells. Furthermore, we discuss the prospective applications of magnetic field therapy in the future treatment of GBM.

中文翻译：

---

胶质母细胞瘤的低频磁场治疗：当前进展、机制、挑战和未来前景

胶质母细胞瘤（GBM）是中枢神经系统最常见的恶性肿瘤。尽管最近在结合手术、放疗、全身治疗（化疗、靶向治疗）和支持治疗的多模式 GBM 治疗方面取得了进展，但总生存期 (OS) 仍然很差，并且长期生存很少见。目前，阻碍GBM治疗效果的主要障碍仍然是血脑屏障和肿瘤异质性。低频磁场（LF-MFs）疗法相对于传统疗法具有穿透能力强、副作用小等显着优势，逐渐引起了科学家的关注。在这篇综述中，我们阐明了 LF-MF 在 GBM 治疗中应用的现状。我们特别强调我们目前对 LF-MF 介导抗癌作用的机制的理解以及 LF-MF 在治疗 GBM 细胞中面临的挑战。此外，我们还讨论了磁场治疗在未来 GBM 治疗中的前瞻性应用。