Trauma‐induced coagulopathy (TIC) is one of the leading causes of preventable death in injured patients. Consequently, it is imperative to understand the mechanisms underlying TIC and how to mitigate this mortality. An opportunity for advancement stems from the awareness that coagulation demonstrates a strong sex‐dependent effect. Females exhibit a relative hypercoagulability compared to males, which persists after injury and confers improved outcomes. The mechanisms underlying sex dimorphisms in coagulation and its protective effect after injury have yet to be elucidated. This review explores sex dimorphisms in enzymatic hemostasis, fibrinogen, platelets, and fibrinolysis, with implications for resuscitation of patients with TIC.

中文翻译：

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凝血中的性别二态性：对创伤性凝血病和创伤复苏的影响

创伤性凝血病（TIC）是受伤患者可预防死亡的主要原因之一。因此，必须了解 TIC 的潜在机制以及如何降低死亡率。进步的机会源于对凝血表现出强烈的性别依赖性效应的认识。与男性相比，女性表现出相对高凝状态，这种状态在受伤后持续存在并改善预后。凝血性别二态性的机制及其损伤后的保护作用尚未阐明。本综述探讨了酶促止血、纤维蛋白原、血小板和纤维蛋白溶解中的性别二态性，以及对 TIC 患者复苏的影响。