Tumor invasion into the lymphatic vasculature represents a critical step during malignant progression of epithelial cancers. In this issue of Cancer Cell, Zheng et al. unravel how cancer-associated fibroblasts interact with lymphatic endothelial cells and the extracellular matrix to promote lymphatic tumor invasion and suggest that these processes could be treatment targets.

中文翻译：

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揭开膀胱癌淋巴管侵犯的隐藏因素

肿瘤侵入淋巴管系统是上皮癌恶性进展过程中的关键步骤。在本期《癌细胞》中，郑等人。揭示癌症相关成纤维细胞如何与淋巴管内皮细胞和细胞外基质相互作用以促进淋巴管肿瘤侵袭，并表明这些过程可能成为治疗目标。