The CHEST Antithrombotic Therapy for Venous Thromboembolism Disease evidence-based guidelines are now updated in a more frequent, focused manner. Guidance statements from the most recent full guidelines and two subsequent updates have not been gathered into a single source. An international panel of experts with experience in prior antithrombotic therapy guideline development reviewed the 2012 CHEST antithrombotic therapy guidelines and its two subsequent updates. All guideline statements and their associated patient, intervention, comparator, and outcome questions were assembled. A modified Delphi process was used to select statements considered relevant to current clinical care. The panel further endorsed minor phrasing changes to match the standard language for guidance statements using the modified Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) format endorsed by the CHEST Guidelines Oversight Committee. The panel appended comments after statements deemed as relevant, including suggesting that statements be updated in future guidelines because of interval evidence. We include 58 guidance statements from prior versions of the antithrombotic therapy guidelines, with updated phrasing as needed to adhere to contemporary nomenclature. Statements were classified as strong or weak recommendations based on high-certainty, moderate-certainty, and low-certainty evidence using GRADE methodology. The panel suggested that five statements are no longer relevant to current practice. As CHEST continues to update guidance statements relevant to antithrombotic therapy for VTE disease, this article serves as a unified collection of currently relevant statements from the preceding three guidelines. Suggestions have been made to update specific statements in future publications.

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VTE 疾病的抗血栓治疗：2012-2021 年 CHEST 指南概要和审查

静脉血栓栓塞病的胸部抗血栓治疗循证指南现在以更频繁、更有针对性的方式更新。最新完整指南和两个后续更新中的指导声明尚未收集到单一来源。具有先前抗血栓治疗指南制定经验的国际专家小组审查了 2012 年 CHEST 抗血栓治疗指南及其随后的两次更新。所有指南声明及其相关的患者、干预、比较和结果问题均已汇总。使用修改后的德尔菲流程来选择被认为与当前临床护理相关的陈述。专家组还同意对措辞进行细微修改，以匹配指导声明的标准语言，使用经 CHEST 指南监督委员会批准的修改后的建议、评估、开发和评估分级 (GRADE) 格式。专家组在被认为相关的陈述后附加了评论，包括建议由于间隔证据而在未来的指南中更新陈述。我们纳入了先前版本的抗血栓治疗指南中的 58 条指导声明，并根据需要更新了措辞，以符合当代术语。使用 GRADE 方法，根据高确定性、中等确定性和低确定性证据将陈述分为强推荐或弱推荐。专家组建议，五项陈述不再与当前实践相关。随着 CHEST 不断更新与 VTE 疾病抗血栓治疗相关的指导声明，本文作为前三个指南中当前相关声明的统一集合。已建议更新未来出版物中的具体声明。