⁹⁰Y-microsphere radioembolization has become a well-established treatment option for liver malignancies and is one of the first U.S. Food and Drug Administration–approved unsealed radionuclide brachytherapy devices to incorporate dosimetry-based treatment planning. Several different mathematical models are used to calculate the patient-specific prescribed activity of ⁹⁰Y, namely, body surface area (SIR-Spheres only), MIRD single compartment, and MIRD dual compartment (partition). Under the auspices of the MIRDsoft initiative to develop community dosimetry software and tools, the body surface area, MIRD single-compartment, MIRD dual-compartment, and MIRD multicompartment models have been integrated into a MIRDy90 software worksheet. The worksheet was built in MS Excel to estimate and compare prescribed activities calculated via these respective models. The MIRDy90 software was validated against available tools for calculating ⁹⁰Y prescribed activity. The results of MIRDy90 calculations were compared with those obtained from vendor and community-developed tools, and the calculations agreed well. The MIRDy90 worksheet was developed to provide a vetted tool to better evaluate patient-specific prescribed activities calculated via different models, as well as model influences with respect to varying input parameters. MIRDy90 allows users to interact and visualize the results of various parameter combinations. Variables, equations, and calculations are described in the MIRDy90 documentation and articulated in the MIRDy90 worksheet. The worksheet is distributed as a free tool to build expertise within the medical physics community and create a vetted standard for model and variable management.

⁹⁰ Y 微球放射性栓塞已成为肝脏恶性肿瘤的成熟治疗选择，并且是美国食品和药物管理局批准的首批未密封放射性核素近距离治疗设备之一，可纳入基于剂量测定的治疗计划。使用几种不同的数学模型来计算患者特定的⁹⁰ Y 规定活动，即体表面积（仅限 SIR-Spheres）、MIRD 单室和 MIRD 双室（分区）。在 MIRDsoft 开发社区剂量测定软件和工具的倡议的支持下，体表面积、MIRD 单室、MIRD 双室和 MIRD 多室模型已集成到 MIRDy90 软件工作表中。该工作表是在 MS Excel 中构建的，用于估计和比较通过这些各自模型计算出的规定活动。 MIRDy90 软件已针对计算⁹⁰ Y 规定活动的可用工具进行了验证。将 MIRDy90 的计算结果与供应商和社区开发的工具获得的结果进行了比较，计算结果吻合得很好。 MIRDy90 工作表的开发目的是提供经过审查的工具，以更好地评估通过不同模型计算的患者特定处方活动，以及模型对不同输入参数的影响。 MIRDy90 允许用户交互并可视化各种参数组合的结果。 MIRDy90 文档中描述了变量、方程和计算，并在 MIRDy90 工作表中进行了阐述。该工作表作为免费工具分发，用于在医学物理界建立专业知识，并为模型和变量管理创建经过审查的标准。