In the SELENIB trial, selenium and vitamin E were compared with placebo as chemoprevention for non-muscle-invasive bladder cancer (NMIBC). No difference versus placebo was observed in recurrence-free interval (RFI) with selenium, but vitamin E was associated with worse RFI. Selenium and vitamin E cannot be recommended in chemoprevention for NMIBC. Furthermore, patients with NMIBC taking supplemental vitamin E should be made aware of its potential association with worse RFI.

中文翻译：

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补充硒和维生素E治疗非肌层浸润性膀胱癌

在 SELENIB 试验中，将硒和维生素 E 与安慰剂作为非肌层浸润性膀胱癌 (NMIBC) 的化学预防进行了比较。与安慰剂相比，硒的无复发间隔 (RFI) 没有观察到差异，但维生素 E 与较差的 RFI 相关。不推荐将硒和维生素 E 用于 NMIBC 的化学预防。此外，服用补充维生素 E 的 NMIBC 患者应意识到其与更严重的 RFI 的潜在关联。