Predisposal of Interferon Regulatory Factor 1 Deficiency to Accumulate DNA Damage and Promote Osteoarthritis Development in Cartilage,Arthritis & Rheumatology

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Predisposal of Interferon Regulatory Factor 1 Deficiency to Accumulate DNA Damage and Promote Osteoarthritis Development in Cartilage
Arthritis & Rheumatology ( IF 13.3 ) Pub Date : 2024-01-25 , DOI: 10.1002/art.42815
Yongsik Cho _{1,

2,

3} , Hyeonkyeong Kim _{1,

2,

3} , Geunho Yook _{1,

2} , Sangmin Yong _{1,

2} , Soy Kim _{1,

2} , Narae Lee _{1,

2} , Yi‐Jun Kim ₄ , Jin‐Hee Kim ₅ , Tae Woo Kim ₆ , Moon Jong Chang ₆ , Kyoung Min Lee ₆ , Chong Bum Chang ₇ , Seung‐Baik Kang ₆ , Jin‐Hong Kim _{1,

2,

8}

Affiliation

Interferon regulatory factor 1 (IRF1) is a transcriptional regulator conventionally associated with immunomodulation. Recent molecular analyses mapping DNA binding sites of IRF1 have suggested its potential function in DNA repair. However, the physiologic significance of this noncanonical function remains unexplored. Here, we investigated the role of IRF1 in osteoarthritis (OA), a condition marked by senescence and chronic joint inflammation.

中文翻译：

干扰素调节因子 1 缺乏易累积 DNA 损伤并促进软骨中骨关节炎的发展

干扰素调节因子 1 (IRF1) 是一种通常与免疫调节相关的转录调节因子。最近绘制 IRF1 DNA 结合位点的分子分析表明其在 DNA 修复中的潜在功能。然而，这种非规范功能的生理意义仍有待探索。在这里，我们研究了 IRF1 在骨关节炎 (OA) 中的作用，骨关节炎是一种以衰老和慢性关节炎症为标志的疾病。

更新日期：2024-01-25

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