Diabetes mellitus (DM)-associated hyperinflammatory host response significantly provokes periodontal tissue destruction. In this context, the support of nonsurgical periodontal therapy in diabetics with host modulation agents is a current field of study. This clinical study aims to investigate the clinical efficacy of melatonin supplementation and discuss its possible biological mechanisms in nonsurgical periodontal treatment in patients with DM and periodontitis through some fundamental markers.

中文翻译：

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褪黑激素支持 2 型糖尿病和牙周炎患者的非手术牙周治疗：一项随机临床试验

糖尿病（DM）相关的高炎症宿主反应会显着引起牙周组织破坏。在这种背景下，用宿主调节剂支持糖尿病患者的非手术牙周治疗是当前的研究领域。本临床研究旨在通过一些基本标志物探讨补充褪黑激素的临床疗效，并探讨其在糖尿病合并牙周炎患者非手术牙周治疗中可能的生物学机制。