Data System. The UK Department of Health and Social Care funded the REal-time Assessment of Community Transmission-2 (REACT-2) study to estimate community prevalence of SARS-CoV-2 IgG (immunoglobulin G) antibodies in England. Data Collection/Processing. We obtained random cross-sectional samples of adults from the National Health Service (NHS) patient list (near-universal coverage). We sent participants a lateral flow immunoassay (LFIA) self-test, and they reported the result online. Overall, 905 991 tests were performed (28.9% response) over 6 rounds of data collection (June 2020-May 2021). Data Analysis/Dissemination. We produced weighted estimates of LFIA test positivity (validated against neutralizing antibodies), adjusted for test performance, at local, regional, and national levels and by age, sex, and ethnic group and area-level deprivation score. In each round, fieldwork occurred over 2 weeks, with results reported to policymakers the following week. We disseminated results as preprints and peer-reviewed journal publications. Public Health Implications. REACT-2 estimated the scale and variation in antibody prevalence over time. Community self-testing and -reporting produced rapid insights into the changing course of the pandemic and the impact of vaccine rollout, with implications for future surveillance. (Am J Public Health. 2023;113(11):1201-1209. https://doi.org/10.2105/AJPH.2023.307381).

中文翻译：

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设计和实施一项利用自我测试监测英格兰 SARS-CoV-2 IgG 抗体流行情况的国家计划：REACT-2 研究。

数据系统。英国卫生和社会保障部资助了社区传播实时评估 2 (REACT-2) 研究，以估计英格兰社区 SARS-CoV-2 IgG（免疫球蛋白 G）抗体的流行情况。数据收集/处理。我们从国家卫生服务 (NHS) 患者名单（接近全民覆盖）中随机获取了成年人的横断面样本。我们向参与者发送了侧流免疫分析（LFIA）自检，他们在线报告了结果。总体而言，在 6 轮数据收集（2020 年 6 月至 2021 年 5 月）中进行了 905 991 次测试（响应率为 28.9%）。数据分析/传播。我们对 LFIA 测试阳性率进行了加权估计（针对中和抗体进行了验证），并根据地方、地区和国家层面的测试表现进行了调整，并按年龄、性别、种族群体和地区层面的剥夺得分进行了调整。每轮实地调查都持续两周以上，结果在下周向政策制定者报告。我们将结果作为预印本和同行评审的期刊出版物进行传播。公共卫生影响。REACT-2 估计了抗体流行率随时间变化的规模和变化。社区自我测试和报告使人们能够快速了解​​大流行的变化过程和疫苗推出的影响，并对未来的监测产生影响。（《美国公共卫生杂志》。2023 年；113(11):1201-1209。https://doi.org/10.2105/AJPH.2023.307381）。