Background and Hypothesis Negative symptoms are very important for the overall loss of functioning observed in patients with schizophrenia. There is a need for valid tools to assess these symptoms. Study Design We used the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) systematic review guideline to evaluate the quality of the clinical assessment interview for negative symptoms (CAINS) as a clinician-rated outcome measurement (ClinROM). Study Results The search strategy resulted in the retrieval of 13 articles, 11 of which were included in this evaluation. In terms of risk of bias, most articles reported on measures of internal consistency and construct validity, which were overall of good quality. Structural validity, reliability, measurement error, and cross-cultural validity were reported with less than optimum quality. There was a risk of bias in ClinROM development. According to the updated criteria of good measurement properties, structural validity, internal consistency, and reliability showed good results. In contrast, hypothesis testing was somewhat poorer. Results for cross-cultural validity were indeterminate. According to the updated GRADE approach from the COSMIN group the scale received a moderate grade. Conclusions The COSMIN standard allows a judgment of the CAINS as an instrument with the potential to be recommended for use, but which requires further research to assess its quality, in particular in the domains of content validity, internal consistency, and cross-cultural validity.

中文翻译：

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阴性症状临床评估访谈 (CAINS)：测量特性的系统回顾

背景和假设 阴性症状对于精神分裂症患者观察到的整体功能丧失非常重要。需要有效的工具来评估这些症状。研究设计 我们使用基于共识的健康测量仪器选择标准 (COSMIN) 系统评价指南来评估阴性症状临床评估访谈 (CAINS) 作为临床医生评定的结果测量 (ClinROM) 的质量。研究结果 检索策略检索到 13 篇文章，其中 11 篇纳入本次评估。在偏倚风险方面，大多数文章报告了内部一致性和结构效度的测量，总体质量良好。结构效度、可靠性、测量误差和跨文化效度的报告质量未达到最佳水平。ClinROM 开发存在偏差风险。根据更新的良好测量特性标准，结构有效性、内部一致性和可靠性显示出良好的结果。相比之下，假设检验则稍差一些。跨文化有效性的结果是不确定的。根据 COSMIN 小组更新的 GRADE 方法，该量表获得中等等级。结论 COSMIN 标准允许判断 CAINS 作为一种有可能被推荐使用的工具，但需要进一步研究来评估其质量，特别是在内容有效性、内部一致性和跨文化有效性领域。